Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats

Bicer, Yasemin; Elbe, Hülya; Karayakali, Melike; Yiğittürk, Gürkan; Yılmaz, Ümit; Cengil, Osman; Gburi, Mohammed Raed Abdullah Al; Altınöz, Eyüp

doi:10.1016/j.jchemneu.2022.102143

Cited by 9 publications

(2 citation statements)

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“…Melatonin also indirectly reduces oxidative stress by upregulating antioxidant enzymes [ 65 ], downregulating pro-oxidant enzymes [ 66 ], and stimulating the synthesis of other endogenous antioxidants, e.g., glutathione [ 67 ]. While the direct free radical scavenging actions of melatonin and its metabolites are generally considered to be receptor-independent, its actions on the redox-related enzymes require the intervention of receptors ( Figure 1 ).…”

Section: Melatonin: Redox Mechanisms For Preserving Reproductive Healthmentioning

confidence: 99%

Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue

et al. 2023

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Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels relative to blood concentrations and its likely synthesis in the oocyte, granulosa, and luteal cells suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review the literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary, especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization–embryo transfer (IVF-ET) procedures, and help solve the progressively increasing problem of non-aging-related infertility in women throughout their reproductive life span. While additional research is needed to fully understand the effects of melatonin supplementation on potentially enhancing fertility, studies published to date suggest it may be a promising option for those struggling with infertility.

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Section: Melatonin: Redox Mechanisms For Preserving Reproductive Healthmentioning

confidence: 99%

Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue

et al. 2023

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“…When carbohydrate-rich foods, especially Westernstyle snacks, are cooked at high temperatures, acrylamide (ACR), a recognized water-soluble hazardous chemical, is produced. ACR has high permeability, making it simple to be absorbed during digestion via the digestive system and spread throughout the body by way of the circulatory system [1] . Accordingly, individuals are continuously exposed to minute levels of ACR found in meals throughout their lives, and its hazardous effects can be seen in a variety of tissues, including the brain [2] .…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Punica granatum peel extract and its alginate-encapsulated nanoparticles against acrylamide-induced neurotoxicity in rats

Tawfek,

El-Houssiny,

Ahmed-Farid

et al. 2023

Egyptian Journal of Pure and Applied Science

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The goal of the present study is to assess the possible protective effect of the pomegranate peel extract (PPE) and its alginate-nanoencapsulated form (Alg-PPE NPs) against rat neurotoxicity induced by acrylamide (ACR). The prepared Alg-PPE NPs were characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, Fourier transmission infrared microscopy (FITR), differential scanning calorimetry (DSC) as well as in vitro cytocompatibility and drug release analysis. The active ingredients of the two examined extracts were identified using HPLC analysis. ACR was intraperitoneally injected (50 mg/kg bw) three times per week for 2 consecutive weeks into male Wistar rats for the induction of neurotoxicity. PPE or Alg-PPE NPS were given in daily doses (200 mg/kg bw) orally for two consecutive weeks either individually or combined with acrylamide injection. Results revealed that ACR injection induced neurotoxicity manifested by the significant increase in tumor necrosis factor alpha, gamma aminobutyric acid, and DNA fragmentation level in brain tissues of treated animals. Meanwhile, the brain levels of brainderived neurotrophic factor, total antioxidant capacity, acetylcholinesterase activity, dopamine, serotonin, norepinephrine, glutamine, glycine, and aspartate were significantly decreased. These changes in tissue biochemical parameters were associated with histopathological alternations in the architecture of brain tissues. Amelioration of the acrylamide-induced brain toxicity was observed following co-administration of either PPE or Alg-PPE NPs with a higher degree of protection observed with the nanoparticles form as a result of increased bioavailability. The protective effect of the studied extracts was ascribed mainly to the antioxidant potential of their phenolic and flavonoids components. In conclusion, Alg-PPE NPs can be regarded as a potential therapeutic agent that offers protection against acrylamide neurotoxicity, however, to fully understand the neuroprotective mechanism of Alg-PPE NPs at the molecular level, additional research must be done to characterize their active principles.

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