Neuroprotection by herbal formula FBD and its active compounds

Lin, Zhihong; Zhu, Daling; Yan, Yi–Dan; Yu, Boyang

doi:10.1080/13880200902913403

Cited by 13 publications

(5 citation statements)

References 25 publications

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“…The representative chemical components of DJS are monoterpene glycosides, phenolic compounds, and phthalides, which exhibit anti-inflammation and anti-oxidant activities (Chen et al, 2009). Especially, albiflorin and paeoniflorin in Paeoniae Radix , atractylenolides in Atractylodis Rhizoma Alba (Lin et al, 2009), and ligustilide in Cnidii Rhizoma and Angelicae Gigantis Radix (Kuang et al, 2006) are known to have multiple bioactivities in neuro-associated diseases. Thus, they may be active components involved in protective effects against oxidative stress, mitochondrial dysfunction, apoptosis, and neuroinflammation.…”

Section: Resultsmentioning

confidence: 99%

Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity

Hwang

Kim

Kwon

et al. 2011

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity

Hwang

Kim

Kwon

et al. 2011

Journal of Ethnopharmacology

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“…Atractylenolide I-III from Atractylodes macrocephala has been reported to have neuroprotective activity against ischemia/reperfusion-like insults in PC12 cells (Lin et al 2009). In our previous study, biatractylenolide, which is responsible for the neuroprotective effect against glutamateinduced excitotoxicity, was isolated from Atractylodis macrocephala.…”

Section: Discussionmentioning

confidence: 98%

Neuroprotective Effect of Biatractylenolide Against Memory Impairment in d-Galactose-induced Aging Mice

Liu

Hong

et al. 2014

J Mol Neurosci

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Biatractylenolide, a sesquiterpene lactone, which exerted the neuroprotective effect against glutamate-induced excitotoxicity, was isolated from Atractylodis macrocephala in our previous study. In this study, we evaluated the neuroprotective effect of biatractylenolide against D-galactose-induced memory impairment and explored the potential mechanism of its action. The results showed that administration of biatractylenolide could significantly improve behavioral performance of D-galactose-treated mice in passive avoidance test and spatial learning-memory test. Administration of biatractylenolide could significantly decrease the formation of reactive oxygen species (ROS), decrease the activity of acetylcholinesterase (AChE), and increase the expression of synapsin I and protein kinase C (PKC) in D-galactose-treated mice. Our findings provide first evidence for the neuroprotective effect of biatractylenolide against D-galactose-induced memory impairment. The potential mechanisms underlying the neuroprotective effect of biatractylenolide in D-galactose-treated mice might be (i) attenuating oxidative damage via decreasing ROS formation, (ii) restoring cholinergic neurotransmission via decreasing AChE activity, and (iii) increasing the expression of memory-related proteins (synapsin I and PKC). Biatractylenolide may have therapeutic potential in aging-related memory impairment.

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“…Compound 1 , a characteristic aromatic acid in CX, has been clinically used to treat angina pectoris and hypertensive diseases in China [ 79 ]. Previous investigations indicated that it could significantly improve blood fluidity, inhibit platelet aggregation, decrease serum lipids, prevent thrombus formation, protect neuron like pheochromocytoma cells (PC12), and exhibit strong antioxidant activity [ 28 , 80 , 81 , 82 , 83 , 84 ]. It was also reported that CX had anti-inflammatory action [ 85 ], could prevent ethanol-induced liver injury [ 86 ], contributed to the defense against viral infections including AIDS [ 87 ], as well as suppress the production of interleukin-8 (IL-8) which was the main cause of the local accumulation of neutrophils, and modulate various inflammatory reactions [ 85 ].…”

Section: Chemical Compounds and Bioactivitiesmentioning

confidence: 99%

Advances in the Chemical Analysis and Biological Activities of Chuanxiong

et al. 2012

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Chuanxiong Rhizoma (Chuan-Xiong, CX), the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae), is one of the most popular plant medicines in the World. Modern research indicates that organic acids, phthalides, alkaloids, polysaccharides, ceramides and cerebrosides are main components responsible for the bioactivities and properties of CX. Because of its complex constituents, multidisciplinary techniques are needed to validate the analytical methods that support CX’s use worldwide. In the past two decades, rapid development of technology has advanced many aspects of CX research. The aim of this review is to illustrate the recent advances in the chemical analysis and biological activities of CX, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques.

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Neuroprotection by herbal formula FBD and its active compounds

Cited by 13 publications

References 25 publications

Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity

Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity

Neuroprotective Effect of Biatractylenolide Against Memory Impairment in d-Galactose-induced Aging Mice

Advances in the Chemical Analysis and Biological Activities of Chuanxiong

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