Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

Abstract

To be added

Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin

“…Moreover, genetic overexpression of amyloid precursor protein in Npc1 Ϫ / Ϫ mice decreased their life span, whereas CYCLO prolonged survival ( 187 ). CYCLO reduced cholesterol sequestration in brains of mouse models of Alzheimer's disease and lowered levels of amyloid by reducing ␤ -cleavage of amyloid precursor protein and increasing expression of genes involved in clearance of ␤ -amyloid plaques ( 188 ). These observations suggest that CYCLO might be a useful therapeutic agent for treatment of Alzheimer's disease and, perhaps also, of other neurodegenerative disorders in which cholesterol homoestasis is disrupted.…”

Development and validation of sensitive LC-MS/MS assays for quantification of HP-#x03B2;-CD in human plasma and CSF

“…Both methods circumvent the challenges posed by the heterogeneity of the HP-␤ -CD mixture and offer analytical approaches that are up to 100-fold more sensitive than the existing method ( 9 ). The availability of assays to accurately and sensitively measure HP-␤ -CD in CSF and plasma not only will assist in drug evaluation for treatment of NPC1 disease, but also will provide critical tools for exploring the utility of HP-␤ -CD in other cholesterol-related diseases, such as atherosclerosis and Alzheimer's disease, in which HP-␤ -CD is being explored as a therapeutic ( 23 ). The current standard for HP-␤ -CD quantifi cation is based on an HPLC method with indirect fl uorescence detection of inclusion complexes ( 9 ).…”

Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules

“…Recently, various bioactivities of CyDs have been demonstrated, and CyDs have been used as active pharmaceutical ingredients (APIs) against Niemann-Pick disease type C (NPC), [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] leukemia, 77) hyperlipidemia, 78) Alzheimer's disease, [79][80][81][82][83][84] cerebral ischemic injury, 85) atherosclerosis, 86) diabetic kidney disease, 87) chronic renal failure, 88) AIDS, 89,90) influenza, 91) peripheral artery disease, 92) sterility, [93][94][95] solid cancers, [96][97][98][99][100][101] bacterial growth, 102) α-synucleinopathy, 103) GM1-gangliosidosis, 104) septic shock, [105][106][107] hypervitaminosis, 108) and transthyretin-related familial amyloidotic polyneuropathy (FAP) …”