“…Nevertheless, resistance to the development of glaucoma demonstrated by some individuals with ocular hypertension and the apparent occurrence of glaucoma in rare individuals with normal or slightly above the normal IOP (normal-tension glaucoma) shows that IOP is not the only significant factor for the disease. Tolerance to a certain IOP contributes to individual variation in the disease, and other factors such as increased ocular peripheral vascular resistance, reduction of blood flow to the optic nerve, the action of excitotoxins, and depletion of neurotrophins in the retinal ganglion cells can interfere, increasing predisposition to glaucoma or triggering it (Marigo et al, 2001). Several reports implicate genetic factors in the etiology of glaucoma; the condition is usually seen in related individuals and specific ethnic groups, often associated with consanguinity in affected families (Sarfarazi et al, 1995).…”
“…Nevertheless, resistance to the development of glaucoma demonstrated by some individuals with ocular hypertension and the apparent occurrence of glaucoma in rare individuals with normal or slightly above the normal IOP (normal-tension glaucoma) shows that IOP is not the only significant factor for the disease. Tolerance to a certain IOP contributes to individual variation in the disease, and other factors such as increased ocular peripheral vascular resistance, reduction of blood flow to the optic nerve, the action of excitotoxins, and depletion of neurotrophins in the retinal ganglion cells can interfere, increasing predisposition to glaucoma or triggering it (Marigo et al, 2001). Several reports implicate genetic factors in the etiology of glaucoma; the condition is usually seen in related individuals and specific ethnic groups, often associated with consanguinity in affected families (Sarfarazi et al, 1995).…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.