Neuroplasticity-related mechanisms underlying the antidepressant-like effects of traditional herbal medicines

Hirshler, Yafit; Doron, Ravid

doi:10.1016/j.euroneuro.2017.07.008

Cited by 10 publications

(8 citation statements)

References 100 publications

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“… 31 It has been noted that D2 receptors are an important potential substrate for DA to participate in antidepressant effects. 32 Neurochemical changes in the DA system are not got enough to understand the mechanism in animal models of depression, 33 however, it is generally accepted that an increased level of DA means that depression has been alleviated. 34 A previous study also showed that the hypothalamus of depressed patients with no drug improvement showed DA dysfunction, and that DA function was normal after remission.…”

Section: Discussionmentioning

confidence: 99%

The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice

Yin

Liu

et al. 2018

RSC Adv.

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Section: Discussionmentioning

confidence: 99%

The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice

Yin

Liu

et al. 2018

RSC Adv.

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“…Currently, herbal therapies are widely used in China as essential alternative medicine and have been reported to ameliorate clinical symptoms of COVID-19 ( Hu et al, 2021 ). Herbal remedies can be taken in many forms in TCM, and studies into their mechanisms of action and therapeutic efficacy are typically categorized by whether they are administered as herbal formulas (multiple herbs prescriptions), individual herbs, or specific phytochemicals (bioactive herbal constituents) ( Hirshler and Doron 2017 ; Lin et al, 2019 ). Below, we discuss the antidepressant effects of these three types of herbal therapies.…”

Section: Herbal Therapies For Depressive Disordersmentioning

confidence: 99%

Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder

Duan

Chen

et al. 2022

Front. Pharmacol.

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Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital role in the pathogenesis of depression by transporting miRNA and effector molecules such as BDNF, IL34. Considering that some herbal therapies exhibit antidepressant effects, EVs might be a practical delivery approach for herbal medicine. Since EVs can cross the blood-brain barrier (BBB), one of the advantages of EV-mediated herbal drug delivery for treating depression with Chinese herbal medicine (CHM) is that EVs can transfer herbal medicine into the brain cells. This review focuses on discussing the roles of EVs in the pathophysiology of depression and outlines the emerging application of EVs in delivering CHM for the treatment of depression.

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“…Notably, many plant-originated drugs were discovered through their use in traditional medicine. Ethnobotanical research, followed by the use of advanced technological tools, molecular and cellular methodology, and valid animal models, serves as a platform for the development of novel active compounds 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract

Murlanova

Cohen

Pinkus

et al. 2022

Sci Rep

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Dittrichia viscosa is a perennial Mediterranean plant used in traditional medicine for “calming purposes”, pointing at a possible antidepressant activity of the plant. We conducted chromatographic and bioassay-guided fractionation of D. viscosa root extract to isolate a specific fraction (fraction “K”) with antidepressant-like characteristics in vivo and strong antioxidant properties in vitro. A single dose of “K” reduced immobility time in the forced swim test with a mouse model possessing a depressive-like phenotype. Neurochemical profiling for 5-hydroxytryptamine (5-HT) and its primary metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in prefrontal cortex and hippocampus of “K”-treated mice showed reduction in 5-HIAA, indicative of either serotonin uptake transporter or monoamine oxidase-A inhibition, as well as slight increases in 5-HT content. These neurochemical alterations, as well as the behavioral changes observed, were comparable to the effects of paroxetine. “K” also protected PC12 cells in a H2O2 cytotoxicity assay, thus demonstrating antioxidant properties, yet paroxetine augmented oxidative damage and cell death. Identification of the main compounds in “K” by high-performance liquid chromatography-tandem mass spectrometry (HPLC–MS/MS) indicated that chlorogenic acid and cynarine comprised 87% of the total components. D. viscosa root extract appears to produce antidepressant and cytoprotective effects and may serve as an attractive alternative to standard therapies for depression.

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Neuroplasticity-related mechanisms underlying the antidepressant-like effects of traditional herbal medicines

Cited by 10 publications

References 100 publications

The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice

The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice

Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder

Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract

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