Neuroplasticity of prehensile neural networks after quadriplegia

Rienzo, Franck Di; Guillot, Aymeric; Mateo, Sébastien; Daligault, Sébastien; Delpuech, Claude; Rode, Gilles; Collet, Christian

doi:10.1016/j.neuroscience.2014.05.021

Cited by 23 publications

(23 citation statements)

References 64 publications

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“…We thus included 10 studies involving five single case (Pfurtscheller et al, 2000 ; Müller-Putz et al, 2005 ; Grangeon et al, 2010 , 2012a ; Rohm et al, 2013 ), two case series (Onose et al, 2012 ; Vučković et al, 2015 ) and three control cases (Cramer et al, 2007 ; Di Rienzo et al, 2014c ; Mateo et al, 2015b ). We scored the quality of these studies using the Single-Case Experimental Design (SCED) scale (Tate et al, 2008 ), the 3 min critical appraisal for case series (Chan and Bhandari, 2011 ) and the Physiotherapy Evidence Database (PEDro) scale (Maher et al, 2003 ; de Morton, 2009 ).…”

Section: Resultsmentioning

confidence: 99%

Motor imagery reinforces brain compensation of reach-to-grasp movement after cervical spinal cord injury

Mateo

Rienzo

Bergeron

et al. 2015

Front. Behav. Neurosci.

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Individuals with cervical spinal cord injury (SCI) that causes tetraplegia are challenged with dramatic sensorimotor deficits. However, certain rehabilitation techniques may significantly enhance their autonomy by restoring reach-to-grasp movements. Among others, evidence of motor imagery (MI) benefits for neurological rehabilitation of upper limb movements is growing. This literature review addresses MI effectiveness during reach-to-grasp rehabilitation after tetraplegia. Among articles from MEDLINE published between 1966 and 2015, we selected ten studies including 34 participants with C4 to C7 tetraplegia and 22 healthy controls published during the last 15 years. We found that MI of possible non-paralyzed movements improved reach-to-grasp performance by: (i) increasing both tenodesis grasp capabilities and muscle strength; (ii) decreasing movement time (MT), and trajectory variability; and (iii) reducing the abnormally increased brain activity. MI can also strengthen motor commands by potentiating recruitment and synchronization of motoneurons, which leads to improved recovery. These improvements reflect brain adaptations induced by MI. Furthermore, MI can be used to control brain-computer interfaces (BCI) that successfully restore grasp capabilities. These results highlight the growing interest for MI and its potential to recover functional grasping in individuals with tetraplegia, and motivate the need for further studies to substantiate it.

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Section: Resultsmentioning

confidence: 99%

Motor imagery reinforces brain compensation of reach-to-grasp movement after cervical spinal cord injury

Mateo

Rienzo

Bergeron

et al. 2015

Front. Behav. Neurosci.

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“…Cervical SCI damages the descending pathways that provide the requisite volitional activation of arm and hand muscles required for hand opening, thereby impairing hand function. While disruption of descending pathways, such as the corticospinal tract, may result in a broad range of altered hand and finger function (Muir and Lemon 1983; Lang and Schieber 2004), spared neural networks and neuromuscular abundancy allow for reorganization and preservation of some hand function (Topka et al 1991; Laffont et al 2000; Koshland et al 2005; Laffont et al 2007; Oudega and Perez 2012; Di Rienzo et al 2014). Nevertheless, the extent to which neuromuscular strategies may enable modulation of hand opening after cervical SCI remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Neural reorganization involving multiple supraspinal structures is evident after SCI (Di Rienzo et al 2014). The nervous system has the capacity to engage parallel corticospinal pathways for mediating hand dexterity after SCI (Darian-Smith et al 1999) due in part to neural reorganization (Topka et al 1991; Bruehlmeier et al 1998; Oudega and Perez 2012).…”

Section: Introductionmentioning

confidence: 99%

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Modulation of hand aperture during reaching in persons with incomplete cervical spinal cord injury

et al. 2014

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The intact neuromotor system prepares for object grasp by first opening the hand to an aperture that is scaled according to object size and then closing the hand around the object. After cervical spinal cord injury (SCI), hand function is significantly impaired, but the degree to which object-specific hand aperture scaling is affected remains unknown. Here we hypothesized that persons with incomplete cervical SCI have a reduced maximum hand opening capacity but exhibit novel neuromuscular coordination strategies that permit object-specific hand aperture scaling during reaching. To test this hypothesis, we measured hand kinematics and surface electromyography (EMG) from seven muscles of the hand and wrist during attempts at maximum hand opening as well as reaching for four balls of different diameters. Our results showed that persons with SCI exhibited significantly reduced maximum hand aperture compared to able-bodied (AB) controls. However, persons with SCI preserved the ability to scale peak hand aperture with ball size during reaching. Persons with SCI also used distinct muscle coordination patterns that included increased co-activity of flexors and extensors at the wrist and hand compared to AB controls. These results suggest that motor planning for aperture modulation is preserved even though execution is limited by constraints on hand opening capacity and altered muscle co-activity. Thus, persons with incomplete cervical SCI may benefit from rehabilitation aimed at increasing hand opening capacity and reducing flexor-extensor co-activity at the wrist and hand.

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“…In clinical settings, single-case pilot experiments yielded that MI practice could improve the tenodesis prehension, i.e., increased movement speed and smoother hand trajectories were reported (Grangeon et al 2012(Grangeon et al , 2010. The authors inferred an effect of the technique on brain neuroplasticity, which was recently evidenced using magnetoencephalography (MEG) (Di Rienzo et al 2014b).…”

Section: Introductionmentioning

confidence: 99%

Neuroplasticity of imagined wrist actions after spinal cord injury: a pilot study

et al. 2014

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Motor imagery (MI - i.e., the mental representation of an action without physically executing it) stimulates brain motor networks and promotes motor learning after spinal cord injury (SCI). An interesting issue is whether the brain networks controlling MI are being reorganized with reference to spared motor functions. In this pilot study, we tested using magnetoencephalography (MEG) whether changes in cortical recruitment during MI were related to the motor changes elicited by rehabilitation. Over a 1-year period of inclusion, C6 SCI participants (n = 4) met stringent criteria for inclusion in a rehabilitation program focused on the tenodesis prehension (i.e., a compensatory prehension enabling seizing of objects in spite of hand and forearm muscles paralysis). After an extended baseline period of 5 weeks including repeated MEG and chronometric assessments of motor performance, MI training was embedded to the classical course of physiotherapy for five additional weeks. Posttest MEG and motor performance data were collected. A group of matched healthy control participants underwent a similar procedure. The MI intervention resulted in changes in the variability of the wrist extensions, i.e., a key movement of the tenodesis grasp (p < .05). Interestingly, the extent of cortical recruitment, quantified by the number of MEG activation sources recorded within Brodmann areas 1-8 during MI of the wrist extension, significantly predicted actual movement variability changes across sessions (p < .001). However, no such relationship was present for movement times. Repeated measurements afforded a reliable statistical power (range .70-.97). This pilot study does not provide straightforward evidence of MI efficacy, which would require a randomized controlled trial. Nonetheless, the data showed that the relationship between action and imagery of spared actions may be preserved after SCI.

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Neuroplasticity of prehensile neural networks after quadriplegia

Cited by 23 publications

References 64 publications

Motor imagery reinforces brain compensation of reach-to-grasp movement after cervical spinal cord injury

Motor imagery reinforces brain compensation of reach-to-grasp movement after cervical spinal cord injury

Modulation of hand aperture during reaching in persons with incomplete cervical spinal cord injury

Neuroplasticity of imagined wrist actions after spinal cord injury: a pilot study

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