Neuroplasticity in the Adaptation to Prosthodontic Treatment

Luraschi, Julien; Korgaonkar, Mayuresh S.; Whittle, Terry; Schimmel, Martín; Müller, Frauke; Klineberg, Iven

doi:10.11607/jop.1097

Cited by 58 publications

(82 citation statements)

References 6 publications

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“…Functional brain imaging studies have revealed that dental stimulation, chewing, and tooth clenching are associated with activation of several nodes of the sensorimotor network, including the S1, M1, premotor and supplementary motor cortices, insula, cerebellum, striatum, and thalamus (Momose et al, 1997; Onozuka et al, 2002; Ettlin et al, 2004; Miyamoto et al, 2006; Luraschi et al, 2013; Shoi et al, 2014; Jiang et al, 2015). Moreover, several of these studies have shown that the level of brain activity is related to the degree of biting force or dentitional state (i.e., whether it was fully dentate, partially- or completely edentate, or restored with dental implants).…”

Section: Discussionmentioning

confidence: 99%

“…For example, human studies have revealed that altered dentitional states including tooth loss and their restoration are accompanied by widespread structural and functional brain changes in regions involved in processing and controlling sensory, motor, cognitive and emotional functions (Yan et al, 2008; Ono et al, 2010; Luraschi et al, 2013; Ohkubo et al, 2013; Shoi et al, 2014). In addition, such changes also occur following training and learning of oral motor skills, as well as in chronic orofacial pain conditions (Momose et al, 1997; Onozuka et al, 2002; Jiang et al, 2010, 2015; Arima et al, 2011; Gerstner et al, 2011; Gustin et al, 2011; Moayedi et al, 2011; Weissman-Fogel et al, 2011; Desouza et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

et al. 2017

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Tooth loss is associated with altered sensory, motor, cognitive and emotional functions. These changes vary highly in the population and are accompanied by structural and functional changes in brain regions mediating these functions. It is unclear to what extent this variability in behavior and function is caused by genetic and/or environmental determinants and which brain regions undergo structural plasticity that mediates these changes. Thus, the overall goal of our research program is to identify genetic variants that control structural and functional plasticity following tooth loss. As a step toward this goal, here our aim was to determine whether structural magnetic resonance imaging (sMRI) is sensitive to detect quantifiable volumetric differences in the brains of mice of different genetic background receiving tooth extraction or sham operation. We used 67 adult female mice of 7 strains, comprising the A/J (A) and C57BL/6J (B) strains and a randomly selected sample of 5 of the 23 AXB-BXA strains (AXB1, AXB4, AXB24, BXA14, BXA24) that were produced from the A and B parental mice by recombinations and inbreeding. This panel of 25 inbred strains of genetically diverse inbred strains of mice is used for mapping chromosomal intervals throughout the genome that harbor candidate genes controlling the phenotypic variance of any trait under study. Under general anesthesia, 39 mice received extraction of 3 right maxillary molar teeth and 28 mice received sham operation. On post-extraction day 21, post-mortem whole-brain high-resolution sMRI was used to quantify the volume of 160 brain regions. Compared to sham operation, tooth extraction was associated with a significantly reduced regional and voxel-wise volumes of cortical brain regions involved in processing somatosensory, motor, cognitive and emotional functions, and increased volumes in subcortical sensorimotor and temporal limbic forebrain regions including the amygdala. Additionally, comparison of the 10 BXA14 and 21 BXA24 mice revealed significant volumetric differences between the two strains in several brain regions. These findings highlight the utility of high-resolution sMRI for studying tooth loss-induced structural brain plasticity in mice, and provide a foundation for further phenotyping structural brain changes following tooth loss in the full AXB-BXA panel to facilitate mapping genes that control brain plasticity following orofacial injury.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

et al. 2017

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“…It was also shown that the patient's age was marginally correlated with the ability to adapt to new dentures . A recent study showed neuroplastic changes during adaptation to an altered oral environment after replacement of dentures in a group of denture users rehabilitated with new dentures . These patients not only demonstrated better chewing efficiency and higher bite force, but also a significant increase in the cortical activity 1 week post‐rehabilitation with new dentures.…”

Section: Neuroplasticity In Dental Prosthetic Patientsmentioning

confidence: 98%

Bite or brain: Implication of sensorimotor regulation and neuroplasticity in oral rehabilitation procedures

Kumar

Kothari

Grigoriadis

et al. 2018

J of Oral Rehabilitation

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Tooth loss, decreased mass and strength of the masticatory muscles leading to difficulty in chewing have been suggested as important determinants of eating and nutrition in the elderly. To compensate for the loss of teeth, in particular, a majority of the elderly rely on dental prosthesis for chewing. Chewing function is indeed an important aspect of oral health, and therefore, oral rehabilitation procedures should aim to restore or maintain adequate function. However, even if the possibilities to anatomically restore lost teeth and occlusion have never been better; conventional rehabilitation procedures may still fail to optimally restore oral functions. Perhaps this is due to the lack of focus on the importance of the brain in the rehabilitation procedures. Therefore, the aim of this narrative review was to discuss the importance of maintaining or restoring optimum chewing function in the superageing population and to summarise the emerging studies on oral motor task performance and measures of cortical neuroplasticity induced by systematic training paradigms in healthy participants. Further, brain imaging studies in patients undergoing or undergone oral rehabilitation procedures will be discussed. Overall, this information is believed to enhance the understanding and develop better rehabilitative strategies to exploit training-induced cortical neuroplasticity in individuals affected by impaired oral motor coordination and function. Training or relearning of oral motor tasks could be important to optimise masticatory performance in dental prosthesis users and may represent a much-needed paradigm shift in the approach to oral rehabilitation procedures.

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“…Colour‐changeable gum is also used to evaluate the chewing efficiency. Commercially available one‐coloured gum is used, and the change in its colour due to chewing is monitored . Chewing efficiency increases significantly over a week of adaptation to new dentures .…”

Section: Introductionmentioning

confidence: 99%

“…Commercially available one‐coloured gum is used, and the change in its colour due to chewing is monitored . Chewing efficiency increases significantly over a week of adaptation to new dentures . Given that chewing efficiency decreases during the adaptation period, it is supposed that chewing efficiency decreases immediately after insertion of an oral appliance with an occlusal flat table and then recovers to some extent over the subsequent week.…”

Section: Introductionmentioning

confidence: 99%

Short‐term changes in chewing efficiency and subjective evaluation in normal dentate subjects after insertion of oral appliances with an occlusal flat table

Satokawa

Minami

Wakabayashi

2017

J of Oral Rehabilitation

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Oral appliances with an occlusal flat table are used as treatment dentures. However, the short-term effect of insertion of such oral appliances on chewing has not been reported. This study aimed to determine whether experimental and continuous insertion of oral appliances with an occlusal flat table has an effect on chewing efficiency and Oral Health Impact Profile (OHIP) in healthy participants. Ten participants each in the oral-appliance and control (no oral-appliance insertion) groups attended six data collection sessions for 5 consecutive days. Participants answered the OHIP questionnaire and underwent the chewing efficiency test. For each parameter, intergroup differences were investigated in terms of change from baseline to immediately after oral-appliance insertion (0 hour; P < .05) and from 0 hour to 24, 48, 72 and 96 hours after oral-appliance insertion (P < .05). There were significant differences between groups in the degree of change in chewing efficiency and OHIP scores for functional limitation, physical pain, physical disability and handicap from baseline to 0 hour (all, P < .001); among these, only OHIP scores for functional limitation and physical pain demonstrated significant differences in degree of change between the two groups at 96 hours after appliance insertion (P = .477 and .275, respectively). Differences between the two groups in the degree of change in other parameters were not significant. Insertion of oral appliances caused a decrease in chewing efficiency and an increase in OHIP scores. Continuous insertion improved functional limitation and physical pain within 96 hours.

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Neuroplasticity in the Adaptation to Prosthodontic Treatment

Cited by 58 publications

References 6 publications

Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

Bite or brain: Implication of sensorimotor regulation and neuroplasticity in oral rehabilitation procedures

Short‐term changes in chewing efficiency and subjective evaluation in normal dentate subjects after insertion of oral appliances with an occlusal flat table

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