Neuroplasticity-Based Cognitive Training in Schizophrenia: An Interim Report on the Effects 6 Months Later

Abstract

A total of 50 hours of neuroplasticity-based computerized cognitive training appears sufficient to drive improvements in verbal learning/memory and cognitive control that endure 6 months beyond the intervention, but a higher "dose" and more "broad-spectrum" training may be necessary to drive enduring gains in processing speed and global cognition. Training-induced cognitive improvement is related to enhanced functioning at 6 months. These data suggest that (1) higher and "broader" doses of cognitive training may confer the most benefits for schizophrenia patients; (2) the posttraining period opens a critical window for aggressive adjunctive psychosocial rehabilitation.

Cognitive Remediation for Schizophrenia: A Review of Recent Findings

“…Two other studies [37,38] that were published before our publication period showed improved verbal memory and auditory neural responses (M100) after intensive auditory training. The MEG findings contradict Rass et al's study [36], but are in line with the original neuroplasticity-based studies from Fisher and colleagues [34,39], which reported significant improvements in verbal learning and memory and global cognition, and maintenance of treatment gains at 6- month follow-up. Thus, the limited data available for this review suggest neuroplasticity-based interventions likely impact functional brain changes associated with basic perceptual/cognitive processes.…”

Neuroplasticity-Based Auditory Training Via Laptop Computer Improves Cognition in Young Individuals With Recent Onset Schizophrenia

“…7,43,44 We are currently investigating whether cognitive gains persist 6 months beyond the intervention and are associated with functional improvement, as previously observed in persistently ill adults. 45 Second, subjects were drawn from 2 university clinics, were of average IQ, and are not representative of community settings. We do not know if this intervention would be as effective in individuals with lower IQ or under 16 years of age.…”

Treating schizophrenia: Game on

“…She has shown that the most-intensive training tested -100 hours -can improve global cognition for as long as six months after the training ends 5 . None of the groups showed a significant improvement in symptom severity or quality of life, but Vinogradov speculates that that was probably partly because there were only about ten patients in each group.…”