Neuroplasticity and regeneration after spinal cord injury

Punjani, Nayaab; Deska-Gauthier, Dylan; Hachem, Laureen D.; Abramian, Madlene; Fehlings, Michael G.

doi:10.1016/j.xnsj.2023.100235

Cited by 4 publications

(1 citation statement)

References 156 publications

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“…Accordingly, advances in IN characterization highlighted other neurons which belong to supraspinal centers and share some genetic features with propriospinal INs, and whose activation impacts upon the activity of ventral horn neurons [9]. Thus, a better understanding of the identity of spared INs able to sprout and to reconstitute functional circuits in the different injury models at different levels of the spinal cord will be critical [80] to design better therapies to support their survival and to boost their growth and maintenance for the recovery of spinal tissue functionality [19]. In parallel, being able to isolate and silence the INs forming aberrant connections that result in detrimental outcomes and poorer life quality to the patients, such as the appearance of pain, spasms, or impaired mobility amelioration due to maladaptive adaptations, would also be of great importance [71].…”

Section: Conclusion Limitations and Perspectives Regarding The Study ...mentioning

confidence: 99%

Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults

Dominguez-Bajo,

Clotman

2024

Cells

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The differential expression of transcription factors during embryonic development has been selected as the main feature to define the specific subclasses of spinal interneurons. However, recent studies based on single-cell RNA sequencing and transcriptomic experiments suggest that this approach might not be appropriate in the adult spinal cord, where interneurons show overlapping expression profiles, especially in the ventral region. This constitutes a major challenge for the identification and direct targeting of specific populations that could be involved in locomotor recovery after a traumatic spinal cord injury in adults. Current experimental therapies, including electrical stimulation, training, pharmacological treatments, or cell implantation, that have resulted in improvements in locomotor behavior rely on the modulation of the activity and connectivity of interneurons located in the surroundings of the lesion core for the formation of detour circuits. However, very few publications clarify the specific identity of these cells. In this work, we review the studies where premotor interneurons were able to create new intraspinal circuits after different kinds of traumatic spinal cord injury, highlighting the difficulties encountered by researchers, to classify these populations.

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Section: Conclusion Limitations and Perspectives Regarding The Study ...mentioning

confidence: 99%

Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults

Dominguez-Bajo,

Clotman

2024

Cells

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Progress in Studying the Mechanism of Spinal Cord Interneurons in Spinal Cord Injury

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2024

ACM

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Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults

Dominguez-Bajo,

Clotman

2024

Preprint

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The differential expression of transcription factors during embryonic development has been selected as the main feature to define the specific subclasses of spinal interneurons. However, recent studies based on single-cell RNA sequencing and transcriptomic experiments suggest that this approach could not be appropriate in the adult spinal cord, where interneurons show overlapping expression profiles, especially in the ventral region. This constitutes a major challenge for the identification and direct targeting of specific populations that could be involved in locomotor recovery after a traumatic spinal cord injury in adults. Current experimental therapies including electrical stimulation, training, pharmacological treatments, or cell implantation that resulted in improvements in locomotor behaviour, rely on the modulation of the activity and connectivity of interneurons located in the surroundings of the lesion core for the formation of detour circuits. However, very few publications clarify the specific identity of these cells. In this work, we review the studies where premotor interneurons were able to create new intraspinal circuits after different kinds of traumatic spinal cord injury, highlighting the difficulties encountered by researchers to classify these populations.

show abstract

Neuroplasticity and regeneration after spinal cord injury

Cited by 4 publications

References 156 publications

Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults

Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults

Progress in Studying the Mechanism of Spinal Cord Interneurons in Spinal Cord Injury

Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults

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