Neuroplasticity and brain reorganization associated with positive outcomes of multidisciplinary rehabilitation in progressive multiple sclerosis: A fMRI study

Péran, Patrice; Nemmi, Federico; Dutilleul, Charlotte; Finamore, L.; Caravasso, Chiara Falletta; Troisi, Elio; Iosa, Marco; Sabatini, Umberto; Grasso, Maria Grazia

doi:10.1016/j.msard.2020.102127

Cited by 14 publications

(17 citation statements)

References 43 publications

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“…Present findings indicate that the use of HBP during rehabilitation intervention normalizes the prefrontal activity, mitigating the prefrontal cortical hyperactivity associated to MS. Similar to our results, a recent study, which assessed the effect of multidisciplinary rehabilitation on the brain activity of MS patients, revealed a significant reduction in the activity of brain areas related to action-related tasks (Péran et al 2020 ).…”

Section: Discussionsupporting

confidence: 92%

Effect of Exoskeleton-Assisted Rehabilitation Over Prefrontal Cortex in Multiple Sclerosis Patients: A Neuroimaging Pilot Study

et al. 2021

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Application of a passive and fully articulated exoskeleton, called Human Body Posturizer (HBP), has been demonstrated to improve mobility, response accuracy and ambulation in multiple sclerosis (MS) patients. By using functional magnetic imaging (fMRI) during a visuomotor discrimination task, we performed a pilot study to evaluate the effect of HBP over the neural correlates of motor and cognitive functions which are typically impaired in MS patients. Specifically, we tested the effect of a 6-week multidisciplinary rehabilitation intervention on two groups of MS patients: a control group who followed a standard physiotherapeutic rehabilitation protocol, and an experimental group who used the HBP during physical exercises in addition to the standard protocol. We found that, after treatment, the experimental group exhibited a significant lower activity (as compared to the control group) in the inferior frontal gyrus. This post-treatment activity reduction can be explained as a retour to a normal range, being the amount of iFg activity observed in the experimental patients very similar to that observed in healthy subjects. These findings indicate that the use of HBP during rehabilitation intervention normalizes the prefrontal activity, mitigating the cortical hyperactivity associated to MS.

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Section: Discussionsupporting

confidence: 92%

Effect of Exoskeleton-Assisted Rehabilitation Over Prefrontal Cortex in Multiple Sclerosis Patients: A Neuroimaging Pilot Study

et al. 2021

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“…Also, some clinical symptoms are not linked to a unique specific structural lesion detected by dMRI sequences, due to its multiple and diffuse representation (functional redundancy across multiple brain regions). Additional MRI modalities, such as functional MRI (fMRI), have been extensively used to monitor the recovery in neurological diseases (Boyd et al, 2010) and outcomes of multidisciplinary rehabilitation (Péran et al, 2020). as assessed through the most advanced neuroimaging techniques, including diffusion tensor imaging and task-related and resting-state functional magnetic resonance imaging (fMRI).…”

Section: Diffusion Mri: Limitations and Future Directions In Neuroplamentioning

confidence: 99%

Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies

Gatto¹

2020

Journal of Integrative Neuroscience

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Advances in the understanding of genetic and molecular mechanisms and imaging technologies have opened a new window of research possibilities to address dynamic processes associated with neuroplasticity in physiologically intact models of neurodegenerative diseases. This review aims to: (i) establish the most relevant molecular mechanisms, as well as cellular and structural biomarkers in the study of neuroplasticity; (ii) introduce different neurodegenerative diseases in animal models that contribute to our knowledge of neuroplasticity; and (iii) illustrate the capabilities and limitations of current diffusion magnetic resonance imaging techniques to study cortical plasticity, as well as the use of alternative diffusion models.

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“…The study designs were as follows: 10 randomized clinical trials (RCT) (Bonzano et al, 2014(Bonzano et al, , 2019Prosperini et al, 2014;Barghi et al, 2018;Kjolhede et al, 2018;Tavazzi et al, 2018;Rocca et al, 2019;Boffa et al, 2020;Prochazkova et al, 2020;Stellmann et al, 2020), plus 1 clinical RCT where the imaging component involved only one subgroup of the intervention arm (Fling et al, 2019). 7 non-randomized clinical trials [1 semi-RCT (Akbar et al, 2020), 2 case-control studies (CC) (Rasova et al, 2005;Ibrahim et al, 2011), 1 case series (CS) (Rasova et al, 2015), 1 parallel-group (PG) (Zuber et al, 2020), 1 self-controlled case series (SCCS) (Peran et al, 2020)].…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…With respect to patient characteristics, most studies recruited both RRMS and PMS (Bonzano et al, 2014(Bonzano et al, , 2019Prosperini et al, 2014;Rasova et al, 2015;Barghi et al, 2018;Tavazzi et al, 2018;Fling et al, 2019;Rocca et al, 2019;Akbar et al, 2020;Prochazkova et al, 2020;Zuber et al, 2020), 2 studies recruited only PMS (Boffa et al, 2020;Peran et al, 2020), 3 studies recruited exclusively RRMS (Ibrahim et al, 2011;Kjolhede et al, 2018;Stellmann et al, 2020), whereas disease phenotype was not reported for 1 study (Rasova et al, 2005).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Neuroplasticity and Motor Rehabilitation in Multiple Sclerosis: A Systematic Review on MRI Markers of Functional and Structural Changes

et al. 2021

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Background: Motor rehabilitation is routinely used in clinical practice as an effective method to reduce progressive disability gain in multiple sclerosis (MS), but rehabilitation approaches are typically unstandardized, and only few studies have investigated the impact of rehabilitation on brain neuroplasticity.Objective: To summarize and critically analyze studies applying MRI markers of functional connectivity and structural changes to assess the effect of motor rehabilitation on brain neuroplasticity in MS.Methods: Literature search was performed using PubMed and EMBASE, selecting studies having as a subject motor rehabilitation and advanced MRI techniques investigating neuroplasticity in adult patients affected by MS.Results: Seventeen out of 798 papers were selected, of which 5 applied structural MRI (4 diffusion tensor imaging, 1 volumetric measurements), 7 applied functional fMRI (5 task-related fMRI, 2 resting-state fMRI) whereas the remaining 5 applied both structural and functional imaging.Discussion: The considerable data heterogeneity and the small sample sizes characterizing the studies limit interpretation and generalization of the results. Overall, motor rehabilitation promotes clinical improvement, paralleled by positive adaptive brain changes, whose features and extent depend upon different variables, including the type of rehabilitation approach. MRI markers of functional and structural connectivity should be implemented in studies testing the efficacy of motor rehabilitation. They allow for a better understanding of neuroplastic mechanisms underlying rehabilitation-mediated clinical achievements, facilitating the identification of rehabilitation strategies tailored to patients' needs and abilities.

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Neuroplasticity and brain reorganization associated with positive outcomes of multidisciplinary rehabilitation in progressive multiple sclerosis: A fMRI study

Cited by 14 publications

References 43 publications

Effect of Exoskeleton-Assisted Rehabilitation Over Prefrontal Cortex in Multiple Sclerosis Patients: A Neuroimaging Pilot Study

Effect of Exoskeleton-Assisted Rehabilitation Over Prefrontal Cortex in Multiple Sclerosis Patients: A Neuroimaging Pilot Study

Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies

Neuroplasticity and Motor Rehabilitation in Multiple Sclerosis: A Systematic Review on MRI Markers of Functional and Structural Changes

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