Neuropilin-2 promotes growth and progression of papillary thyroid cancer cells

Lee, Geonho; Kang, Yea Eun; Oh, Chahyun; Liu, Lihua; Jin, Yanli; Lim, Mi Ae; Won, Ho-Ryun; Chang, Jae Won; Koo, Bon Seok

doi:10.1016/j.anl.2020.03.013

Cited by 9 publications

(8 citation statements)

References 41 publications

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“…NRP2 has also been found to be closely associated with metastasis and BRAFV600E in thyroid cancer [54]. Downregulation of NRP2 has been shown to influence epithelial-mesenchymal transition by affecting phosphorylation signaling pathways [54]. This suggests a potential association of NRP2 expression with the TME and gene mutations.…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma

Deng

Guo

Yan

et al. 2021

BioMed Research International

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Background. Neurovascular-related genes have been implicated in the development of cancer. Studies have shown that a high expression of neuropilins (NRPs) promotes tumourigenesis and tumour malignancy. Method. A multidimensional bioinformatics analysis was performed to examine the relationship between NRP genes and prognostic and pathological features, tumour mutational burden (TMB), microsatellite instability (MSI), and immunological features based on public databases and find the potential prognostic value of NRPs in pancancer. Results. Survival analysis revealed that a low NRP1 expression in adrenocortical carcinoma (ACC), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), low-grade glioma (LGG), and stomach adenocarcinoma (STAD) was associated with poor prognosis. A high NRP2 expression in bladder urothelial carcinoma (BLCA), kidney renal papillary cell carcinoma (KIRP), and mesothelioma (MESO) was associated with poor prognosis. Moreover, NRP1 and NRP2 were associated with TMB and MSI. Subsequent analyses showed that NRP1 and NRP2 were correlated with immune infiltration and immune checkpoints. Genome-wide association analysis revealed that the NRP1 expression was strongly associated with kidney renal clear cell carcinoma (KIRC), whereas the NRP2 expression was closely associated with BLCA. Ultimately, NRP2 was found to be involved in the development of BLCA. Conclusions. Neurovascular-related NRP family genes are significantly correlated with cancer prognosis, TME, and immune infiltration, particularly in BLCA.

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Section: Biomed Research Internationalmentioning

confidence: 99%

Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma

Deng

Guo

Yan

et al. 2021

BioMed Research International

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“…NRP2 expression has been associated both with increased proliferation rate as well as with the capability of tumor cells to escape from programmed cell death in cancer cells ( 13 , 50 , 51 ). We observed decreased cell viability in NRP2 knockdown cells, but further studies are needed to clarify whether this is a consequence of lower proliferation rate or increased cell death.…”

Section: Discussionmentioning

confidence: 99%

Neuropilin-2 Is Associated With Increased Hepatoblastoma Cell Viability and Motility

et al. 2021

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The neuropilins NRP1 and NRP2 are multifunctional glycoproteins that have been implicated in several cancer-related processes including cell survival, migration, and invasion in various tumor types. Here, we examine the role of neuropilins in hepatoblastoma (HB), the most common pediatric liver malignancy. Using a combination of immunohistochemistry, RNA analysis and western blotting, we observed high level expression of NRP1 and NRP2 in 19 of 20 HB specimens and in a majority of human HB cell lines (HUH6 and five cell lines established from patient-derived xenografts) studied but not in normal hepatocytes. Silencing of NRP2 expression in HUH6 and HB-282 HB cells resulted in decreased cell viability, impaired cytoskeleton remodeling, and reduced cell motility, suggesting that NRP2 contributes to the malignant phenotype. We propose that neuropilins warrant further investigation as biomarkers of HB and potential therapeutic targets.

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“…In previous studies, the cellular functions of NRP2 have been disclosed in various cancers. For example, in papillary thyroid cancer, NRP2 could promote cell growth and is closely associated with extrathyroid extension and lymph node metastasis [ 34 ]. It was also reported that NRP2 could act as an independent prognostic factor for prostate adenocarcinoma patients, as its upregulation was correlated with the worse outcome of patients [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis

et al. 2021

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Neuropilin-2 promotes growth and progression of papillary thyroid cancer cells

Cited by 9 publications

References 41 publications

Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma

Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma

Neuropilin-2 Is Associated With Increased Hepatoblastoma Cell Viability and Motility

lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis

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