Neurophysiology of Migraine

Pierelli, Francesco; Omland, Petter Moe; Sand, Trond

doi:10.1007/978-3-319-15621-7_8

Cited by 3 publications

(1 citation statement)

References 136 publications

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“…Neurophysiological patterns of migraine phases have been discovered with various neuroimaging tools, including fMRI, PET, MEG, and EEG (6)(7)(8). In contrast with high spatial resolution, the EEGrecorded electrical activity of the cerebral cortex, using extracranial electrodes, provides a high temporal resolution that enables the examination of brain dynamics on the millisecond scale.…”

Section: Introductionmentioning

confidence: 99%

Exploring resting-state EEG complexity before migraine attacks

et al. 2017

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Objective Entropy-based approaches to understanding the temporal dynamics of complexity have revealed novel insights into various brain activities. Herein, electroencephalogram complexity before migraine attacks was examined using an inherent fuzzy entropy approach, allowing the development of an electroencephalogram-based classification model to recognize the difference between interictal and preictal phases. Methods Forty patients with migraine without aura and 40 age-matched normal control subjects were recruited, and the resting-state electroencephalogram signals of their prefrontal and occipital areas were prospectively collected. The migraine phases were defined based on the headache diary, and the preictal phase was defined as within 72 hours before a migraine attack. Results The electroencephalogram complexity of patients in the preictal phase, which resembled that of normal control subjects, was significantly higher than that of patients in the interictal phase in the prefrontal area (FDR-adjusted p < 0.05) but not in the occipital area. The measurement of test-retest reliability (n = 8) using the intra-class correlation coefficient was good with r1 = 0.73 ( p = 0.01). Furthermore, the classification model, support vector machine, showed the highest accuracy (76 ± 4%) for classifying interictal and preictal phases using the prefrontal electroencephalogram complexity. Conclusion Entropy-based analytical methods identified enhancement or "normalization" of frontal electroencephalogram complexity during the preictal phase compared with the interictal phase. This classification model, using this complexity feature, may have the potential to provide a preictal alert to migraine without aura patients.

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Section: Introductionmentioning

confidence: 99%

Exploring resting-state EEG complexity before migraine attacks

et al. 2017

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Elucidation of the levels of vitamin D, calcium, and magnesium in the serum of Egyptian migraine patients: a case-control study

Elsayed

Amin

Elsayed

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background Migraine, although, is a prevalent disease; its pathogenesis is complex and still not fully elucidated. The effect of vitamin D on various neurological disorders is thought to be exerted either directly via its specific receptors or through the related minerals. We investigated the possible relationship between vitamin D level and its related minerals (calcium and magnesium) and migraine characteristics in patients. Subjects and methods Thirty healthy individuals and 60 age- and sex-matched migraineurs (22 chronic and 38 episodic migraineurs), diagnosed according to the International Headache Society criteria (ICHD-III), were recruited. After obtaining basic data, a visual analogue scale (VAS) for the severity of migraine pain was assessed. Migraine severity questionnaire (MIGSEV) and the Migraine Disability Assessment (MIDAS) questionnaire were given and illustrated to the participants. Blood samples were obtained, and serum concentrations of vitamin D, calcium, and magnesium were determined. Results Migraine patients had significantly lower level of serum vitamin D and magnesium than healthy subjects with (P < 0.001 and P = 0.04), respectively. However, the difference between the serum calcium levels of the patient and the control group was not statistically significant. Moreover, vitamin D and magnesium had a significant negative correlation with frequency, duration, severity, and disability in migraine. Conclusion Vitamin D and magnesium were significantly deficient in migraine patients and were related to the severity and disability of migraine attacks. Low vitamin D and magnesium levels were associated with more frequency and longer duration of migraine attacks.

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Post lumbar puncture headache: Case report of a serious adverse event in first-in-human study

Shin

Kim

et al. 2017

Transl Clin Pharmacol

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Neurophysiology of Migraine

Cited by 3 publications

References 136 publications

Exploring resting-state EEG complexity before migraine attacks

Exploring resting-state EEG complexity before migraine attacks

Elucidation of the levels of vitamin D, calcium, and magnesium in the serum of Egyptian migraine patients: a case-control study

Post lumbar puncture headache: Case report of a serious adverse event in first-in-human study

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