Neurophysiological study on normal aged adults. By means of somatosensory evoked response (SER) and contingent negative variation (CNV).

Fujimoto, Osamu; Koga, Takashi; Ohta, Yoshitaka; Fujii, Hisakazu; Nan'no, Hisashige; Nishimura, Tsuyoshi

doi:10.3143/geriatrics.23.146

Cited by 1 publication

(5 citation statements)

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“…Mid‐latency SER components are believed to correlate with cerebral reactivity to somatosensory stimuli. P2 is supposed to be the response in the primary sensory cortex and N2 is the response in the secondary sensory cortex and the association area of the cortex 10,11 . N3 is believed to be generated widely within the association area of the cortex, and N3 latency is thought to be involved with cerebral reactivity to stimuli 10,11 .…”

Section: Discussionmentioning

confidence: 99%

“…P2 is supposed to be the response in the primary sensory cortex and N2 is the response in the secondary sensory cortex and the association area of the cortex 10,11 . N3 is believed to be generated widely within the association area of the cortex, and N3 latency is thought to be involved with cerebral reactivity to stimuli 10,11 . Prolongation of N3 latency is observed in normal aging, whereas in patients with organic brain syndromes, such as DAT, N3 latency is significantly prolonged compared with healthy aged people 10–12 .…”

Section: Discussionmentioning

confidence: 99%

“…Contingent negative variation is believed to reflect expectancy, attention, motivation and arousal level during the paradigm 10,11 , 13,14 . Abnormal CNV morphologies and decreased CNV amplitude in schizophrenics, which have been regarded as a manifestation of their disabilities of attention or hyperarousal state, have been reported by many investigators 13–17 .…”

Section: Discussionmentioning

confidence: 99%

“…10,11 N3 is believed to be generated widely within the association area of the cortex, and N3 latency is thought to be involved with cerebral reactivity to stimuli. 10,11 Prolongation of N3 latency is observed in normal aging, whereas in patients with organic brain syndromes, such as DAT, N3 latency is significantly prolonged compared with healthy aged people. [10][11][12] In the present study, N3 latencies of LP patients, as well as those of patients with DAT, were Mean values (+SD) of N3 latency, CNV amplitude and P300 latency for the control, 'non-atrophic' and 'atrophic' late paraphrenia (LP) groups.…”

Section: Discussionmentioning

confidence: 99%

“…Contingent negative variation is believed to reflect expectancy, attention, motivation and arousal level during the paradigm. 10,11,13,14 Abnormal CNV morphologies and decreased CNV amplitude in schizophrenics, which have been regarded as a manifestation of their disabilities of attention or hyperarousal state, have been reported by many investigators. [13][14][15][16][17] In the present study, CNV morphologies of chronic schizophrenics differed significantly from those of healthy aged subjects, and their CNV amplitudes were also significantly decreased compared with the healthy aged, but LP subjects showed no significant difference from the healthy aged on either morphology or amplitude of CNV.…”

Section: Figurementioning

confidence: 99%

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Neurophysiological evaluation of late paraphrenia: Comparison with chronic schizophrenia and dementia of the Alzheimer type

et al. 2003

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Background: Late paraphrenia (LP) is a clinical entity first proposed by Roth in 1955. Recently, neuroimaging studies have described the organic changes in the brain that are associated with LP. We performed a neurophysiological study on patients with LP, chronic schizophrenics and patients with dementia of the Alzheimer type (DAT) to examine the cognitive function of patients with LP and to differentiate LP patients from these other groups. Methods: We investigated somatosensory‐evoked response (SER), contingent negative variation (CNV) and P300 in 30 LP patients, 22 chronic schizophrenics and 31 patients with DAT. Thirty‐four age‐matched healthy volunteers served as a control group. SER was performed by applying a mechanical stimulus to the right or left palm. CNV was performed by presenting a clicking sound (S1) and a flash of light (S2) to the subjects, with an interval between S1 and S2 of 2 s. P300 was performed using an auditory oddball paradigm. Results: The mean N3 peak latency of SER was significantly prolonged in patients with LP and in patients with DAT, compared with the control group. The mean CNV amplitude was significantly decreased in schizophrenics compared with the control group, but it did not decrease in patients with LP. The mean N200 and P300 latencies were significantly prolonged in patients with DAT compared with the control group, LP patients and schizophrenics, but the latencies of patients with LP were not prolonged compared with the control group. Conclusion: Based on these results, we propose that patients with LP have impaired cerebral reactivity to the stimulus, but their attention, motivation, recognition and differentiation are relatively intact. The present findings are consistent with former investigations, indicating that patients with LP are less likely to show negative symptoms, such as personality deterioration, and more likely to show organic changes in the brain relative to schizophrenics arising in early life.

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Section: Discussionmentioning

confidence: 99%