Neurophysiological signs of cocaine dependence: Increased electroencephalogram beta during withdrawal

Herning, Ronald I.; Guo, Xiaoyan; Better, Warren; Weinhold, Linda L.; Lange, W; Cadet, Jean Lud; Gorelick, David A.

doi:10.1016/s0006-3223(96)00258-2

Cited by 37 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased EEG beta has also been reported in patients who suffer from vertebrobasilar artery insufficiency (Niedermeyer 1963). When considered together with these observations, our findings suggest that the repeated use of cocaine may contribute to a state of vascular insufficiency which is associated with subclinical cognitive deficits (Herning et al 1991;O'Malley et al 1992;Roberts and Bauer 1993;Easton and Bauer 1997), EEG changes (Alper et al 1990(Alper et al , 1998Noldy et al 1994;Roemer et al 1995;Prichep et al 1997;Herning et al 1997b;Costa and Bauer 1997) and imaging alterations (Tumeh et al 1990;Weber et al 1990;Volkow et al 1991;Holman et al 1991;Levin et al 1994Levin et al , 1995. This idea is supported by the findings that EEG observed in cocaine abusers was normalized by nimodipine (Herning et al 1995), a drug known to improve blood flow (Godfraind et al 1990).…”

Section: Discussionsupporting

confidence: 67%

“…It is interesting to note that the neuropsychological and EEG deficits previously reported (Herning et al 1997b;Costa and Bauer 1997) might be related to the reduced blood flow velocity being reported herein. Thus, reduced cerebral blood flow velocity might be associated with neuropsychological deficits in a mechanism similar to changes observed in vascular dementia (Biedert et al 1995;Sattel et al 1996;Starkstein et al 1996).…”

Section: Discussionmentioning

confidence: 48%

“…With cocaine-related stroke as a neurological complication, it is reasonable to suggest an increased prevalence of subclinical neurovascular deficits in this population. EEG (Alper et al 1990(Alper et al , 1998Noldy et al 1994;Roemer et al 1995;Prichep et al 1997;Herning et al 1997b;Costa and Bauer 1997). PET/ SPECT blood flow (Tumeh et al 1990;Weber et al 1990;Volkow et al 1991;Holman et al 1991;Levin et al 1994Levin et al , 1995, and neuropsychological (Herning et al 1991;O'Malley et al 1992;Roberts and Bauer 1993;Easton and Bauer 1997) studies have indeed found that prolonged cocaine abuse is associated with subtle, subclinical CNS deficits.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Neurovascular Deficits in Cocaine Abusers

Herning

King

Better

et al. 1999

Neuropsychopharmacology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 48%

mentioning

confidence: 99%

See 1 more Smart Citation

Neurovascular Deficits in Cocaine Abusers

Herning

King

Better

et al. 1999

Neuropsychopharmacology

View full text Add to dashboard Cite

“…Our group, and others, have reported excess alpha activity (Alper et al, 1990;Lukas, 1991;Herning et al, 1994;Roemer et al, 1995;Prichep et al, 1996a) and decreased delta activity (Alper et al, 1990;Noldy et al, 1994;Roemer et al, 1995;Prichep et al, 1996a, b), while others have reported increased beta power (Herning et al, 1985(Herning et al, , 1997Noldy et al, 1994) in cocaine-dependent patients, recorded in eyes closed, resting conditions. The qEEG abnormalities, primarily found in anterior cortical regions, were shown to correlate with the amount of prior cocaine use (Prichep et al, 1996a;Herning et al, 1997;Roemer et al, 1995). In a recent cue exposure study, we found evidence for an increase in beta power during the handling of cocaine paraphernalia and the viewing of a crack cocaine video, and an increase in delta power during guided imagery related to cocaine craving.…”

Section: Introductionmentioning

confidence: 47%

Topographic Imaging of Quantitative EEG in Response to Smoked Cocaine Self-Administration in Humans

Reid

Flammino

Howard

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Quantitative electroencephalographic (qEEG) profiles were studied in cocaine-dependent patients in response to an acute, single-blind, self-administered dose of smoked cocaine base (50 mg) vs placebo. qEEG data were averaged using neurometric analytical methods and the spectral power of each primary bandwidth was computed and topographically imaged. Additional measures included cocaineinduced high, craving, and related subjective ratings, heart rate, blood pressure, and plasma cortisol and homovanillic acid levels. In all, 13 crack cocaine-dependent subjects were tested. Cocaine produced a rapid increase in subjective ratings of cocaine high and good drug effect, and a more persistent increase in cocaine craving and nervousness. Cocaine also produced a rapid rise in heart rate and a prolonged increase in plasma cortisol. Placebo, administered in the context of cocaine cues and dosing expectations, had no cocaine-like subjective or physiological effects. Cocaine produced a rapid increase in absolute theta, alpha, and beta power over the prefrontal cortex (FP1, FP2), lasting up to 25 min after dosing. The increase in theta power was correlated with good drug effect, and the increase in alpha power was correlated with nervousness. Cocaine also produced a similar increase in delta coherence over the prefrontal cortex, which was positively correlated with plasma cortisol, and negatively correlated with nervousness. Placebo resulted in an increase in alpha power over the prefrontal cortex. These data demonstrate the involvement of prefrontal cortex in the qEEG response to acute cocaine. Evidence indicates slow wave qEEG, delta and theta activity, involvement in the rewarding properties of cocaine.

show abstract

“…The most frequently observed abnormality in substance-dependent subjects is an increased activity (power) in the 13-to 25-Hz or beta frequency range [4,15,28,31]. However, the significance of this increased beta power is not known.…”

Section: Introductionmentioning

confidence: 99%

Electroencephalographic Power and Coherence Analyses Suggest Altered Brain Function in Abstinent Male Heroin-Dependent Patients

et al. 2004

View full text Add to dashboard Cite

Previous studies have shown that drug abuse is associated with altered brain function. However, studies of heroin abuse-related brain dysfunctions are scarce. Electroencephalographic (EEG) power and coherence analyses are two important tools for examining the effects of drugs on brain function. In the present study, we compared EEG power and coherence measures of 18 abstinent heroin-dependent subjects with those of 12 healthy control subjects. Furthermore, within the heroin group, associations between heroin use in the past, heroin craving and these EEG measures were studied. The results show that heroin-dependent subjects have increased relative beta-2 power and increased left intrahemispheric gamma coherence compared with control subjects. Furthermore, coherence measures showed correlations with clinical variables. These EEG abnormalities may reflect underlying changes in brain function due to long-term drug abuse and premorbid characteristics.

show abstract

Neurophysiological signs of cocaine dependence: Increased electroencephalogram beta during withdrawal

Cited by 37 publications

References 28 publications

Neurovascular Deficits in Cocaine Abusers

Neurovascular Deficits in Cocaine Abusers

Topographic Imaging of Quantitative EEG in Response to Smoked Cocaine Self-Administration in Humans

Electroencephalographic Power and Coherence Analyses Suggest Altered Brain Function in Abstinent Male Heroin-Dependent Patients

Contact Info

Product

Resources

About