Neurophysiological reactivity before a migraine attack

Siniatchkin, Michael; Averkina, N A; Andrasik, Frank; Stephani, Ulrich; Gerber, Wolf‐Dieter

doi:10.1016/j.neulet.2006.02.019

Cited by 60 publications

(62 citation statements)

References 15 publications

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“…This interpretation is in line with numerous evoked potential studies that have applied similar protocols (e.g. Afra et al, 1998;Ambrosini et al, 2003;Brodsky et al, 2013;Chen et al, 2009;Coppola et al, 2013b;Ozkul and Uckardes, 2002;Sand et al, 2008;Schoenen et al, 1995;Siniatchkin et al, 2006;Valeriani et al, 2003). The present study did not aim to investigate if the amplitude decline during VEP stimulation is caused by habituation in the central nervous system.…”

Section: Progressive Amplitude Changes During Recoding Of Vepsupporting

confidence: 71%

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Omland

Uglem

Hagen

et al. 2016

Clinical Neurophysiology

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Please cite this article as: Omland, P.M., Uglem, M., Hagen, K., Linde, M., Tronvik, E., Sand, T., Visual evoked potentials in migraine: Is the "neurophysiological hallmark" concept still valid ?, Clinical Neurophysiology (2015), doi: http://dx.doi.org/10. 1016/j.clinph.2014.12.035 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. • Lack of VEP habituation is not a reliable "neurophysiological hallmark" in interictal migraine• Strict focus on methodology, including blinding during the recording and assessment of VEP, is important to avoid overestimation of effect sizes in future studies.2 Abstract Objective Lack of habituation is considered a neurophysiological hallmark of migraine. However, the results of visual evoked potential (VEP) studies have been discrepant, possibly because of different stimulation parameters and lack of blinding. Hence, there is a need for independent confirmation of lack of VEP habituation in migraine. In this blinded study we applied 16' checks to supplement our previous findings with 8', 31', 62' and 65' checks. MethodsVEPs in 41 interictal migraineurs and 30 controls were compared. VEPs were recorded in six blocks of 100 single responses. Linear N70-P100 amplitude change over blocks (habituation slope) was compared with an independent samples Student's t-test. ResultsAmplitude decline over blocks was observed in both groups. Habituation slope was not significantly different between controls (-0.43 ± 0.54 μV/block) and migraineurs (-0.29 ± 0.35 μV/block) (p = 0.33). ConclusionVEP habituation with 16' checks did not differ in migraineurs and controls. This is in agreement with previous findings with other stimulation parameters. It is therefore unlikely that use of different stimulation parameters could explain the discrepant results of previous studies. No studies that applied blinding during recording of VEP have found lack of habituation in migraineurs. SignificanceLack of VEP habituation cannot be considered a reliable neurophysiological hallmark in migraine.

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Section: Progressive Amplitude Changes During Recoding Of Vepsupporting

confidence: 71%

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Omland

Uglem

Hagen

et al. 2016

Clinical Neurophysiology

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“…She cited that the opposite pattern might be true in those with abnormal levels of cortical arousal, such as migraineurs and depressive patients. This is consistent with a growing body of literature showing that migraineurs exhibit abnormal cortical excitability and deficient inhibition (Andrasik and Rime 2007;Schoenen 2006;Siniatchkin et al 2006). In migraineurs, cortical hypersensitivity and deficient habituation in response to visual and auditory stimuli peak just before migraine onset.…”

Section: Electrophysiological Rationalesupporting

confidence: 89%

Headache Treatment with Pulsing Electromagnetic Fields: A Literature Review

Vincent

Andrasik

Sherman

2007

Appl Psychophysiol Biofeedback

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Pulsing electromagnetic field (PEMF) therapy may be a viable form of complementary and alternative medicine. Clinical applications include the treatment of fractures, wounds, and heart disease. More recent applications involve treatment of recurrent headache disorders. This paper reviews available studies investigating PEMF for headache management. Possible mechanisms for effects (neurochemical, electrophysical, and cardiovascular) are discussed. The available data suggest that PEMF treatment for headache merits further study. Suggestions for future research are provided.

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“…Eine Überregbarkeit des Migränikerhirns wird weiterhin von elektrophysiologischen Studien gestützt, die u. a. die CNV ("contingent negative variation") untersuchten. In Migränepopulationen (mit und ohne Aura) wurde mehrfach eine erhöhte CNVAmplitude im attackenfreien Intervall gefunden [27,36,46,47,48,49]. Diese Ergebnisse sprechen für eine generell erhöhte neurophysiologische Suszeptibilität des Migränikerhirns.…”

Section: Introductionunclassified

Kortikale Dysbalance des Migränikerhirns – Hyperexzitabilität als Folge einer Sensitisierung?

Stankewitz

May

2008

Schmerz

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A cortical dysbalance has a pivotal role in the pathophysiology of migraine. Numerous electrophysiological and transcranial magnetic stimulation (TMS) studies have investigated the interictal excitability level in migraineurs and have shown a consistent lack of habituation during repetitive stimulation. There is some controversy in the current literature over whether this deficit is based on a lowered or an elevated preactivation level. However, the current discussion may be misguided. It seems that multiple external and intrinsic factors influence the level of cortical excitability and the frequency and intensity of attacks: Habituation is specific neither to migraine nor even to pain; the same phenomenon is found in tinnitus patients, for example. Cortical hyperexcitability is presumably the result of chronicity and the concomitant central sensitisation process.

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Neurophysiological reactivity before a migraine attack

Cited by 60 publications

References 15 publications

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Headache Treatment with Pulsing Electromagnetic Fields: A Literature Review

Kortikale Dysbalance des Migränikerhirns – Hyperexzitabilität als Folge einer Sensitisierung?

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