Neurophysiological properties of pallidal neurons in Parkinson's disease

Sterio, Djordje; Berić, Aleksandar; Dogali, Michael; Fazzini, Enrico; Alfaro, George; Devinsky, Orrin

doi:10.1002/ana.410350512

Cited by 189 publications

(108 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differentiation of neurons was accomplished according to established criteria. [16,30,38,40] Commonly, neurons of the putamen, the GPe, the laminar borders, and the GPi were mapped along the pathway. When the ventral border of the GPi was identified, the recording was supplemented by microstimulation at 3 to 4 mm below it.…”

Section: Surgical Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Microelectrode-guided posteroventral pallidotomy for treatment of Parkinson's disease: postoperative magnetic resonance imaging analysis

Krauss¹,

Desaloms²,

Lai³

et al. 1997

FOC

View full text Add to dashboard Cite

The authors report the postoperative magnetic resonance (MR) imaging findings in 36 patients with advanced Parkinson's disease who underwent unilateral microelectrode-guided posteroventral pallidotomy. The lesions were placed within 1 mm of the ventral border of the globus pallidus internus (GPi) to include pallidothalamic outflow pathways. Sequential MR studies were obtained within 1 to 3 days postoperatively and at 6-month follow-up examination. Thirty-four (94%) of the 36 patients enjoyed sustained moderate or marked improvement of their parkinsonian symptoms 6 months postoperatively. Transient side effects occurred in five patients (14%), but there were no persistent complications. The pallidal radiofrequency lesions were prolate spheroid-shaped and were composed of three concentric zones in the early postoperative studies. The mean volume of the middle zone, corresponding to the area of hemorrhagic coagulation necrosis, was 44.4 +/- 17.6 mm3; the mean lesion volume as defined by the outer zone, corresponding to perilesional edema, was 262.2 +/− 111.6 mm3. Additional edema spreading to the internal capsule was noted in 32 of 34 cases and to the optic tract in 11 of 34 cases. In two patients small ischemic infarctions involving the corona radiata were found, and in one a venous infarction was detected. Ischemic infarction resulted in mild transient Broca's aphasia in one patient, but there was no detectable neurological deficit in the other two. The mean volume of late-phase (6 months) lesions was 22 +/− 28.8 mm3. In three patients no lesion was identified despite sustained clinical improvement. The lesion was located in the posteroventral GPi in all cases except in one patient in whom it was confined to the GP externus (GPe). This 49-year-old woman did not experience sustained benefit. The authors found no consistent correlations between lesion size and location and clinical outcome as measured by a global outcome score, the Unified Parkinson's Disease Rating Scale motor, activities of daily living, and bradykinesia “off” scores or rating of dyskinesias. Lesioning of pallidal and subpallidal pathways may contribute to the sustained clinical benefit in this series. Magnetic resonance imaging analysis showed that intraoperative microelectrode recording facilitated accurate placement of the lesion in this critical area.

show abstract

Section: Surgical Proceduresmentioning

confidence: 99%

“…The procedure is associated with low morbidity, and symptomatic and functional improvement is achieved in the majority of patients. [30,38] Many questions, however, remain to be answered. [20,35] Few data are available on postoperative magnetic resonance (MR) imaging.…”

mentioning

confidence: 99%

Microelectrode-guided posteroventral pallidotomy for treatment of Parkinson's disease: postoperative magnetic resonance imaging analysis

Krauss¹,

Desaloms²,

Lai³

et al. 1997

FOC

View full text Add to dashboard Cite

show abstract

“…Pallidal single-cell discharge characteristics are best documented in Parkinson's disease (PD). PD in the off-medication state has been found to be associated with excessive and abnormally patterned neuronal activity in the motor territory of the GPi (Hutchison 1998;Levy et al 2001;Magnin et al 2000;Sterio et al 1994). …”

Section: Introductionmentioning

confidence: 99%

Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson’s Disease and Normal Macaque

Starr¹,

Rau²,

Davis³

et al. 2005

Journal of Neurophysiology

246

183

View full text Add to dashboard Cite

. Dystonia is a movement disorder defined by sustained muscle contractions, causing twisting and repetitive movements and abnormal postures. To understand the abnormalities in pallidal discharge in dystonia, we have analyzed the spontaneous activity of 453 neurons sampled from the internal or external pallidum (GPi or GPe) of 22 patients with dystonia, 140 neurons from 11 patients with Parkinson's disease (PD), and 157 neurons from two normal non-human primates (NHPs; Macacca mulatta). All recordings were performed without systemic sedation. Mean GPi discharge rate in dystonia was 55.3 Ϯ 1.3 (SE) Hz. This was significantly lower than in the normal NHPs (82.5 Ϯ2.5 Hz) and lower than in PD patients (95.2 Ϯ 2.3 Hz). Mean GPe discharge rate in dystonia (54.0 Ϯ 1.9 Hz) was lower than in the normal NHPs (69.7 Ϯ 3.3 Hz) and was indistinguishable from that in PD patients (56.6 Ϯ 3.5 Hz). Mean GPi discharge rate was inversely correlated with dystonia severity. GPi showed increased oscillatory activity in the 2-to 10-Hz range and increased bursting activity in both dystonia and PD as compared with the normal NHPs. Because the abnormalities in discharge patterns were similar in dystonia compared with PD, we suggest that bursting and oscillatory activity superimposed on a high background discharge rate are associated with parkinsonism, whereas similar bursting and oscillations superimposed on a lower discharge rate are associated with dystonia. Our findings are most consistent with a model of dystonia pathophysiology in which the two striatal cell populations contributing to the direct and indirect intrinsic pathways of the basal ganglia both have increased spontaneous activity.

show abstract

“…The main output of the basal ganglia is indeed via the pallidothalamic tract into the thalamus. Due to a reduction of dopamine in the striatum, increased neuronal activity of the internal part of the globus pallidus (GPi) (Albin et al, 1989;Beric et al, 1996;DeLong, 1990;Hutchison et al, 1994;Lozano et al, 1998;Magnin et al, 2000;Sterio et al, 1994), causes a tonic overinhibition of the pallidal-recipient thalamic relay cells leading to a thalamocortical dysrhythmic interplay, named thalamocortical dysrhythmia (TCD), characterized by an overproduction of thalamic low threshold calcium spike bursts and an increase in low and high frequency EEG power (Jeanmonod et al, 1996Llinas, 1984;Llinas and Pare, 1994;Llinás et al, 2001;Llinás et al, 1999;Magnin et al, 2000;Volkmann et al, 1992Volkmann et al, , 1996.…”

Section: Introductionmentioning

confidence: 99%

Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients

et al. 2008

View full text Add to dashboard Cite

(2008). Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients. NeuroImage, 41(3):985-997. Postprint available at: http://www.zora.uzh.ch Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients Abstract Oscillatory and coherent EEG activity is increasingly recognized as a fundamental hallmark of cortical integrative functions. We aimed to study deviations from the norm of different resting EEG parameters in Parkinson's disease (PD) patients. We compared spectral parameters of the resting EEG of PD patients (n=24, median age 67 years) to those of healthy controls (n=34, median age 62 years). On average, the patient group exhibited higher spectral power over the frequency range of 2-100 Hz, and the dominant peak was shifted towards lower frequencies. Maximal differences appeared in the 6-9 Hz theta band in all electrodes. Frontal electrodes contributed most to this difference in the 4-6 Hz theta, 12-18 Hz beta and 30-45 Hz gamma bands. On an individual basis, the combination of six spectral power band parameters discriminated between patient and control groups and 72% of all subjects were classified correctly. Using LORETA source analysis, the generators of this power difference were localized to fronto-insulo-temporal cortical areas in the theta and beta bands, and to interhemispheric frontal (supplementary motor area, SMA) and cingulate areas in the 30-45 Hz gamma band. We calculated spectral coherence between electrode pairs in a frontal, central and parietal region of interest (ROI). In the frontal ROI, coherence was enhanced significantly in the patient group in the theta, high beta and gamma bands. In the parietal ROI, patients showed lower coherence around 10 Hz. We demonstrate a deviation from the norm of different resting EEG parameters in PD patients. This evidence can be integrated in the context of a pathophysiological chain reaction initiated in the substantia nigra and resulting in a cortical aberrant dynamics rooted in enhanced dysrhythmic thalamocortical interactions.Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients Oscillatory and coherent EEG activity is increasingly recognized as a fundamental hallmark of cortical integrative functions. We aimed to study deviations from the norm of different resting EEG parameters in Parkinson's disease (PD) patients. We compared spectral parameters of the resting EEG of PD patients (n = 24, median age 67 years) to those of healthy controls (n = 34, median age 62 years).On average, the patient group exhibited higher spectral power over the frequency range of 2-100 Hz, and the dominant peak was shifted towards lower frequencies. Maximal differences appeared in the 6-9 Hz theta band in all electrodes. Frontal electrodes contributed most to this difference in the 4-6 Hz theta, 12-18 Hz beta and 30-45 Hz gamma bands. On an individual basis, the combination of six spectral power band parameters discr...

show abstract

Neurophysiological properties of pallidal neurons in Parkinson's disease

Cited by 189 publications

References 25 publications

Microelectrode-guided posteroventral pallidotomy for treatment of Parkinson's disease: postoperative magnetic resonance imaging analysis

Microelectrode-guided posteroventral pallidotomy for treatment of Parkinson's disease: postoperative magnetic resonance imaging analysis

Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson’s Disease and Normal Macaque

Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients

Contact Info

Product

Resources

About