Neurophysiological Markers Related to Negative Self-referential Processing Differentiate Adolescent Suicide Ideators and Attempters

Allison, Grace O.; Benau, Erik M.; Asbaghi, Steven; Pagliacco, David; Stewart, Jessica; Auerbach, Randy P.

doi:10.1016/j.bpsgos.2021.04.001

Cited by 13 publications

(18 citation statements)

References 92 publications

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“…Results of the PCA yielded two temporospatial factors (TFSF) that resembled the LPP (Foti et al., 2009 ). Of note, though the LPP is often observed at parieto‐occipital sites in youth when viewing affective images (Burkhouse et al., 2017 ; Kujawa et al., 2013 ), the LPP to words during self‐referential processing is localized to fronto‐central electrodes in both youth (Allison et al., 2021 ; Auerbach et al., 2015 ) and adults (Dainer‐Best et al., 2017 ). TF2SF1 accounted for 10.25% of the variance and showed peak positivity at 897 ms and electrode C3, whereas TF4SF1 accounted for 2.87% of the variance and showed peak positivity at 1243 ms and electrode CP1.…”

Section: Methodsmentioning

confidence: 99%

Risk for youth anxiety during the COVID‐19 pandemic: The interactive impact of financial stress and prepandemic electrocortical reactivity to negative self‐referential stimuli

Feurer

Granros

Calentino

et al. 2022

Developmental Psychobiology

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Despite evidence that stress exposure increases risk for internalizing symptoms in youth, it remains unclear which youth are most vulnerable. This study examined whether youth's prepandemic late positive potential (LPP), an electrocortical marker of sustained attention to affective stimuli, exacerbated the impact of stress on prospective increases in depression and anxiety symptoms from before to during the COVID‐19 pandemic. Participants were 29 youth (ages 9–16, 82.8% girls) who completed depression and anxiety symptom measures and an affective words task to assess LPP to positive and negative self‐referential stimuli prepandemic onset. Postpandemic onset, approximately 16.03 months (SD = 8.86) after their baseline assessments, youth again completed symptom measures as well as the UCLA Life Stress Interview to assess ongoing social and financial chronic stress. Results indicated a significant interaction between youth LPP to negative words and financial stress. Greater exposure to financial stress during the pandemic predicted greater anxiety symptom increases specifically for youth who demonstrated enhanced prepandemic LPP to negative words. Results were specific to the prediction of anxiety, but not depression, symptoms. If replicated in larger studies, findings highlight enhanced LPP to negative stimuli as a promising target for intervention for youth exposed to greater financial stress.

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Section: Methodsmentioning

confidence: 99%

Risk for youth anxiety during the COVID‐19 pandemic: The interactive impact of financial stress and prepandemic electrocortical reactivity to negative self‐referential stimuli

Feurer

Granros

Calentino

et al. 2022

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…However, to provide support for the hypotheses the model makes about life stress, research must assess stress severity across multiple types (e.g., acute events, chronic difficulties) and domains (e.g., interpersonal, independent) and determine their relation to suicidal thinking, in general, versus suicide attempts, specifically. Indeed, many variablesincluding depressive disorders and psychiatric symptom severity-are consistently associated with STBs in youth (see Cha et al, 2018) but are not related to suicide attempts among ideators STRESS, DEPRESSION, AND SUICIDAL THOUGHTS AND BEHAVIORS (Allison et al, 2021;Alqueza et al, 2021;Nock et al, 2013;Stewart et al, 2019).…”

Section: Theoretical Formulations Of Stress and Suicidementioning

confidence: 99%

Stress exposure in at-risk, depressed, and suicidal adolescents

Stewart¹,

Pizzagalli²,

Auerbach³

2022

Preprint

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Stress exposure contributes to the onset, maintenance, and recurrence of Major Depressive Disorder (MDD) in adolescents. However, the precise stress features (e.g., chronicity, domain) most strongly linked to outcomes at different stages along the depression severity continuum remain unclear. Across two studies, we employed a gold-standard contextual stress interview to comprehensively assess stress exposure among: (a) healthy youth with (High-Risk) and without (Low-Risk) a maternal history of MDD and (b) adolescents with current MDD and healthy community controls. In Study 1, compared to Low-Risk, High-Risk status was associated with more severe chronic stress, as well as more severe independent (e.g., a parent’s chronic medical condition) and interpersonal events. In Study 2, more severe interpersonal event threat was uniquely associated with: (a) being depressed (versus non-depressed) and (b) experiencing a recent suicide attempt. Collectively, these results underscore the increased saliency of interpersonal stress in understanding depression and suicide, particularly among adolescents with more severe clinical presentations.

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“…If alterations in the P2 waveform also precede negative urgency, it seems possible that effects in the Allison et al. ( 2 ) study could have been even stronger if people with comorbid diagnoses that are characteristically impulsive (e.g., history of mania, substance use, or head injury) were included in the sample. Nevertheless, early controlled attention may contribute to negative urgency, which in turn could serve to trigger suicidal behavior.…”

mentioning

confidence: 99%

“…In the current issue of Biological Psychiatry: Global Open Science , Allison et al. ( 2 ) report interesting work with exciting implications for future research on adolescent suicide. A primary finding from this cross-sectional study is that a neurophysiological waveform, known as P2, generated early (i.e., approximately 200 ms after stimulus onset) during self-referent processing of positive and negative adjectives, differentiates individuals with SI who have attempted suicide ( n = 26) from those who have not ( n = 30).…”

mentioning

confidence: 99%