Neurophysiological Effects ofEuphorbia hirta L. (Euphorbiaceae)

Abstract

A lyophilized aqueous extract of Euphorbia hirta L. (Eh) has been evaluated for benzodiazepine‐like properties and for hypnotic, neuroleptic and antidepressant properties, in order to complete the study of dose‐dependent sedative and analgesic effects previously demonstrated. The plant extract did not protect mice against the convulsant effects of pentylenetetrazol, it did not cause muscle relaxant effects and it did not seem to possess any affinity for benzodiazepine receptors. In addition, Eh did not have its own hypnotic effects in mice, but it intensified those of barbiturates, and caused a direct action on the central nervous system. This aqueous extract did not possess neuroleptic activity, but slight antidepressant effects were obtained against reserpine‐induced ptosis and oxotremorine‐induced hypothermia.

Estudo botânico, fitoquímico e fisico-químico de Euphorbia hirta L. (Euphorbiaceae)

“…Possui atividades antibacteriana (Vijaya et al, 1995;Sudhakar et al, 2006), antifúngica (Polachini, 2004), antiretroviral (Gyuris et al, 2009) antiespasmódica (Gnecco et al,1996apud kumar, 2010, antianafilática (Youssouf et al, 2007), antialérgica (Singh et al, 2006), ansiolítica (Anuradha et al, 2008), antimalárica (Liu et al, 2007), anti-leucêmica (Jain et al, 2009) e anti-inflamatória contra asma (Ekpo & Pretorius, 2007). Estudos também demonstraram que esta planta diminui a motilidade gastrintestinal (Hore et al, 2006), reduz a degeneração da cartilagem em casos de artrite (Lee et al, 2008), é antidepressiva (Lanhers et al, 1996), sedativa e ansiolítica (Lanhers et al,, 1990), e pode apresentar diarreia severa como principal efeito colateral, se utilizada em altas doses (Al-Qura'n, 2005).…”

Antimalarial Flavonol Glycosides fromEuphorbia hirta.

“…After an antimalarial screening of Congolese medicinal plants, we have observed that the MeOH extract of Euphorbia hirta Linn (Euphorbiaceae) (OliverBever, 1986;Iwu, 1993) demonstrated not only potent in vitro antimalarial activity against P. falciparum but also little cytotoxic property against human epidermoid carcinoma KB 3-1 cells. The antimalarial activity of E. hirta extracts has been previously reported (Tona et al, 1999(Tona et al, , 2004Kö hler et al, 2002;Koli et al, 2002), in addition to other healing properties, such as antiulcer (Lin & Hsu, 1988), antimicrobial (Oyewale et al, 2002;Sudhakar et al, 2006), antibacterial (Satyanarayana & Singhai, 1979;Vijaya et al, 1995), anti-Helicobacter pylori (Wang & Huang, 2005), sedative and anxiolytic (Lanhers et al, 1990), neurophysiologic (Lanhers et al, 1996), antihypertensive (Williams et al, 1997;Johnson et al, 1999), antihistaminic and immunosuppressive (Singh et al, 2006), molluscicidal (Singh et al, 2005), antiamebic (Tona et al, 2000), antifungal (Masood & Rajan, 1991), spasmolytic (Tona et al, 2000), antidiarrheic (Galvez et al, 1993a(Galvez et al, , 1993bMallavadhani et al, 2002;Hore et al, 2006), analgesic and antipyretic (Lanhers et al, 1991), and anti-inflammatory (Lanhers et al, 1991;Martinez-Vazquez et al, 1999;Singh et al, 2006). Phytochemical investigation on this species led to the isolation of tannins (Lanhers et al, 1991;Yoshida et al, 1988Yoshida et al, , 1990a…”

La thérapie par les plantes en Afrique: activités immunostimulantes des polysaccharides de la paroi végétale

“…Les fruits du tamarinier sont des gousses à pulpe comestible. Lanhers et al [19] ont montré que les xyloglucanes extraits des grains de tamarin ont plusieurs activités biologiques telles que l'effet inhibi teur sur les cellules de la famille des polyomavirus (BK) et sur l'activité immunomodulatrice. Elles ont aussi des activités biologiques sur la prolifération des cytokines dans différentes lignées des cellules de la peau [12].…”