Neurophysiological correlates of psychomotor activity in chronic schizophrenics

Chiarenza, Giuseppe A.; Papakōstopoulos, D.; Dini, Massimo; Cazzullo, C. L.

doi:10.1016/0013-4694(85)91087-9

Cited by 71 publications

(6 citation statements)

References 29 publications

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“…As for the P200 component, its physiological significance is currently under reconsideration (for review, see Crowley and Colrain 2004). P200 may reflect early stimulus evaluation and corresponds to information inhibition processes in cortical and subcortical structures (Catts et al 1986;Chiarenza et al 1985;Oades et al 1996). The idea that NE and DA neurotransmitter systems may modulate P200 elucidates several findings concerning ERP abnormalities in schizophrenia and ADHD.…”

Section: Discussionmentioning

confidence: 95%

The effect of methylphenidate on auditory information processing in healthy volunteers: a combined EEG/MEG study

2008

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The lack of effect of MPH on either MMN or MMNm suggests no association between catecholaminergic activities and MMN generation. However, our findings imply that MPH may change the neural bases of auditory information processing such as the early stimulus evaluation reflected in the P200 component. Dopamine and noradrenaline neurotransmitter systems could be responsible for the modulation of these processes. The exclusive effect of MPH on the P200 component could have a clinical application.

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Section: Discussionmentioning

confidence: 95%

The effect of methylphenidate on auditory information processing in healthy volunteers: a combined EEG/MEG study

2008

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“…ERPs associated with selfinitiated movements correspond especially to attentional involvement in movement preparation (bereitschaftspotential or BP) and perhaps the receipt of movement feedback (reafferent potential or P2). Both have been reported abnormal in schizophrenia -low amplitude for the BP (Chiarenza et al 1985;Kaku et al 1986) and delay or absence of the P2 (Timsit-Berthier et al 1973;Takasaka 1985) -but these have not yet been studied longitudinally.…”

Section: Motor Disturbances In Schizophrenia Andrew Cridermentioning

confidence: 99%

The neuropsychology of schizophrenia

Gray¹,

et al. 1991

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A model is proposed for integrating the neural and cognitive aspects of the positive symptoms of acute schizophrenia, using evidence from postmortem neuropathology and neurochemistry, clinical and preclinical studies of dopaminergic neurotransmission, anatomical connections between the limbic system and basal ganglia, attentional and other cognitive abnormalities underlying the positive symptoms of schizophrenia, specific animal models of some of these abnormalities, and previous attempts to model the cognitive functions of the septohippocampal system and the motor functions of the basal ganglia. Anatomically, the model emphasises the projections from the septohippocampal system, via the subiculum, and the amygdala to nucleus accumbens, and their interaction with the ascending dopaminergic projection to the accumbens. Psychologically, the model emphasises a failure in acute schizophrenia to integrate stored memories of past regularities of perceptual input with ongoing motor programs in the control of current perception. A number of recent experiments that offer support for the model are briefly described, including anatomical studies of limbic-striatal connections, studies in the rat of the effects of damage to these connections, and of the effects of amphetamine and neuroleptics, on the partial reinforcement extinction effect, latent inhibition and the Kamin blocking effect; and studies of the latter two phenomena in acute and chronic schizophrenics.

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“…Interestingly, the P2 EEG response, which is considered to be an analogue of the M150 magnetic response has been proposed to reflect DA and NA activities [204]. M150 may reflect early stimulus evaluation and correspond to information inhibition processing in cortical and subcortical structures [205][206][207]. Importantly, deficits in inhibitory control were reported by a large number of studies on subjects with OCD [208,209].…”

Section: Early Sensory Processingmentioning

confidence: 99%

The Utility of Electromagnetic Activity Measures in Obsessive Compulsive Disorder and Schizophrenia

Harris¹,

Korostenskaja²

2014

Obsessive-Compulsive Disorder - The Old and the New Problems

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The prevalence of both OCD and SCZ is high, with estimates across the globe ranging from 1-2% of the population [1][2][3][4]. There is significant morbidity associated with both of these conditions [5]. Symptoms of these diseases may impact the individual's family, and ability to work and contribute to society. The quality of life of patients with OCD is impaired primarily during the symptomatic state but less so when patients are treated or in remission [6,7]. Close to 76% of patients with SCZ are unable to engage in basic social roles, even when psychotic symptoms are in remission; few marry, and less than one third are in regular employment [8]. Nine to thirteen percent of patients with schizophrenia commit suicide [9].The prevalence of obsessive compulsive symptoms in patients with SCZ ranges from 7.8%[10] to 25% [11]. Whereas less than 2% of patients with OCD develop psychotic symptoms [12]. The age of onset of OCD is bimodal with peaks both in children and young adults [13]; the typical age of onset of SCZ is in the third decade of life with childhood onset being extremely rare [14]. Clinical characteristicsThe clinical presentation of OCD and SCZ is currently what is used to diagnose and distinguish these conditions. OCD is characterized by the presence of obsessions and/or compulsions [15]. Obsessions are unwanted thoughts or images that recur. Compulsions are repetitive behaviors or mental acts that an individual feels driven to perform. Patients with OCD often describe either a sense of incompleteness if a ritual is not done just right or a sense that something bad will happen if they don't perform the ritual. SCZ, on the other hand, is characterized by positive and negative symptoms [15]. Positive symptoms refer to additional symptoms that are not present in a healthy individual such as hallucinations, delusions, and thought disorder. Negative symptoms refer to deficits, such as, lack of facial expressions and emotional variability, decreased energy and diminished verbal output. Cognitive dysfunction [16] and disorganized behavior may be present as well and include disorganized speech, bizarre behavior and poor attention [17].While OCD and SCZ are described as distinct psychiatric disorders [18], some authors argue that a "schizo-obsessive disorder" exists as well [19][20][21]. Indeed, a subset of individuals with SCZ present with obsessive compulsive symptoms and a subset of patients with OCD lack insight. Some have concluded from this overlap, that there is a spectrum of disorders that ranges from: [1] OCD, [2] OCD with poor insight, [3] OCD with schizotypal personality disorder, [4] schizophrenia with obsessive compulsive symptoms, [5] SCZ with OCD and [6] SCZ [22].

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Neurophysiological correlates of psychomotor activity in chronic schizophrenics

Cited by 71 publications

References 29 publications

The effect of methylphenidate on auditory information processing in healthy volunteers: a combined EEG/MEG study

The effect of methylphenidate on auditory information processing in healthy volunteers: a combined EEG/MEG study

The neuropsychology of schizophrenia

The Utility of Electromagnetic Activity Measures in Obsessive Compulsive Disorder and Schizophrenia

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