Neurophysiological and neurochemical alterations during electrical stimulation of human caudate nucleus

Jh, Wood; Lake, C. Raymond; Mg, Ziegler; J, Van Buren

doi:10.3171/jns.1977.46.3.0361

Cited by 7 publications

(2 citation statements)

References 53 publications

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“…Van Buren [8] commented that stimulation to the head of the caudate nucleus would cause an interference of change in psychic process; Wood [10] has recently supported the opinion of Van Buren. Our observations may support Van Buren's opinion, but in detail there are some differ ences between them.…”

Section: Discussionmentioning

confidence: 99%

Arrest Reaction in Man

Kwak¹,

Okudaira²,

Sakamoto³

et al. 1978

Stereotact Funct Neurosurg

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In spite of many reports of arrest reaction in animals, there are very few reports in man. During a therapeutic stereotactic operation we observed peculiar phenomena caused by electrical stimulation to the deep structure of the cerebrum. This phenomenon is quite similar to that reported by Van Buren, but there are a few differences between them. Arrest reaction was observed in 14 of 23 cases, 17 of 28 tracks. Stimuli which caused the arrest reaction were 60–100 Hz square waves of 1 msec duration and 5–15 V. The electrical stimulation caused an interruption of counting and other motor actions, which could be resumed following release of stimuli. Psychic confusion or memory disturbances were not observed with the exception of a few cases. The arrest reaction that we observed is thought to be due to a direct effect on the head of the caudate nucleus, not due to secondary effects on the internal capsule and the motor fiber in the vicinity of the caudate nucleus. However, the possibility that the current spread to the motor fiber cannot be definitely ruled out.

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Section: Discussionmentioning

confidence: 99%

Arrest Reaction in Man

Kwak¹,

Okudaira²,

Sakamoto³

et al. 1978

Stereotact Funct Neurosurg

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“…The caudate stimulation study [12] included 1 patient with intractable thalamic pain following evacuation of a left thalamocapsular hematoma, 1 patient with right hemiparkinsonism, 1 patient with spasmodic torticollis and retrocollis, and 2 patients with dystonia musculorum deformans ( Table 2). Their mean age was 38 & 8 gears.…”

Section: Methodsmentioning

confidence: 99%

Cerebrospinal fluid norepinephrine reductions in man after degeneration and electrical stimulation of the caudate nucleus

Wood

Lake

Shoulson

et al. 1977

Annals of Neurology

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Lumbar cerebrospinal fluid (CSF) norepinephrine concentrations determined by radioenzymatic assay in 9 patients with caudate atrophy associated with Huntington's disease were lower ( p < 0.02) than those i n 9 age-and sex-matched control patients.Preoperative lumbar CSF norepinephrine concentrations were determined in 5 patients undergoing stereotaxic thalamotomy. No significant alterations in prestimulation lumbar CSF norepinephrine levels were recorded 12 days after electrode installation and thalamic coagulation. Lumbar CSF norepinephrine concentrations were reduced ( p < 0.03), however, 1 2 hours following intermittent selective electrical stimulation of the caudate nucleus.These data suggest that noradrenergic pathways in man are (1) impaired in Huntington's disease and (2) inhibited by direct caudate stimulation.Wood JH, Ziegler MG, Lake CR, et al: Cerebrospinal fluid norepinephrine reductions in man after degeneration and electrical stimulation of the caudate nucleus. A n n Neurol 1: [94][95][96][97][98][99] 1977

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