Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia

Hochberger, William C.; Joshi, Yash B.; Michael, Thomas; Zhang, Wendy; Bismark, Andrew W.; Treichler, Emily B. H.; Tarasenko, Melissa; Nungaray, John; Sprock, Joyce; Cardoso, Lauren; Swerdlow, Neal R.; Light, Gregory A.

doi:10.1038/s41386-018-0256-9

Cited by 48 publications

(38 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cognitive training must address limitations in perceptual/pre-attentive processing first (for a review, (Vinogradov et al, 2012)). This hope was preliminarily bolstered by some finding of learning-induced neuroplasticity, in which training in early auditory or visual processes results in substantial gains in verbal or visual cognitive processes through "bottom-up" tuning of the neural systems (Adcock et al, 2009;Biagianti et al, 2016;Dale et al, 2016;Fisher et al, 2009;Hochberger et al, 2019;Surti et al, 2011).…”

Section: Implications For Future Treatment Studiesmentioning

confidence: 99%

Altered Sensorimotor-to-Transmodal Hierarchical Organization in Schizophrenia

Dong

Yao

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

For decades, schizophrenia has been primarily conceptualized as a disorder of high-order cognitive functions with deficits in executive brain regions. Yet due to the increasing reports of early sensory processing deficit, recent models focus more on the developmental effects of impaired sensory process on high-order functions. The present study examined whether this pathological interaction relates to an overarching system-level imbalance, specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. We applied a novel combination of connectome gradient and stepwise connectivity analysis to resting-state functional magnetic resonance imaging (rsfMRI) to characterize the sensorimotor-to-transmodal cortical hierarchy organization (96 patients vs. 122 controls). Using these techniques, we demonstrated compression of the cortical hierarchy organization in schizophrenia, with a prominent compression from the sensorimotor region and a less prominent compression from the frontal-parietal region, resulting in a diminished separation between sensory and fronto-parietal cognitive systems. Further analyses suggested reduced differentiation related to atypical functional connectome transition from unimodal to transmodal brain areas. Specifically, we found hypo-connectivity within unimodal regions and hyper-connectivity between unimodal regions and frontoparietal and ventral attention regions along the classical sensation-to-cognition continuum established in prior neuroanatomical work. The compression of cortical hierarchy organization represents a novel and integrative system-level substrate underlying the pathological interaction of early sensory and cognitive function in schizophrenia. This abnormal cortical hierarchy organization suggests cascaded impairments stemming from the disrupted somatosensory-motor system and inefficient integration of bottom-up sensory information with attentional demands and executive control processes partially account for high-level cognitive deficits characteristic of schizophrenia.

show abstract

Section: Implications For Future Treatment Studiesmentioning

confidence: 99%

Altered Sensorimotor-to-Transmodal Hierarchical Organization in Schizophrenia

Dong

Yao

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…RON is thought to reflect a reorienting of attention back to the foreground task, though the underlying psychological construct is less developed. Important for the current study, the ADR complex has been shown to be sensitive to a number of CNS perturbations including acute pharmacologic challenges and cognitive training interventions (16)(17)(18)(19)(20)(21)(22). The ADR components are translational biomarkers elicited in the absence of directed attention and index functionally relevant networks, thus they are increasingly used as biomarkers in the development of interventions that target CNS dysfunction (17,21,(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Impaired Sensory Processing During Low-Oxygen Exposure: A Noninvasive Approach to Detecting Changes in Cognitive States

Seech

Funke²,

Sharp

et al. 2020

Front. Psychiatry

Self Cite

View full text Add to dashboard Cite

The ability to detect novelty in our environment is a critical sensory function. A reliable set of event-related potentials (ERP), known as the auditory deviance response (ADR), are elicited in the absence of directed attention and indexes functionally relevant networks. The ADR consists of three peaks: mismatch negativity (MMN), P3a, and reorienting negativity (RON) that are sequentially evoked in response to unattended changes in repetitive background stimulation. While previous studies have established the ADR's sensitivity to a range of pharmacologic and nonpharmacologic interventions and are leading candidate biomarkers of perturbations of the central nervous system (CNS), here we sought to determine if ADR peaks are sensitive to decreases in breathable oxygen. Participants performed a visuomotor tracking task while EEG was recorded during two 27-min sessions. The two sessions differed in the amount of environmental oxygen available: 10.6% O 2 (hypoxia) versus 20.4% O 2 (normoxia). ERPs were measured while a series of identical, or "standard," tones combined with occasional "oddball," tones, were presented. MMN, P3a, and RON were assessed in response to the oddball compared to the standard stimuli. Behavioral impairment during hypoxia was demonstrated by a deficit in tracking performance compared to the normoxia condition. Whereas no changes were detected in the MMN or RON, the amplitude of the P3a component was significantly reduced during hypoxia compared to normoxia, within the first 9 min of exposure. To our knowledge, this is the first study to demonstrate the effect of low oxygen exposure on passively elicited neural measures of early sensory processing. This study demonstrates that passively elicited EEG measures, reflecting preattentive auditory processing, are disrupted by acute hypoxia. Results have implications for the development of biomarkers for the noninvasive assessment of CNS perturbations.

show abstract

“…This sensory prediction error response has also been shown to relate to functional ability in people at risk for schizophrenia [8]. There are pilot studies indicating it may be able to predict and be an objective indicator of people who would benefit from psychosocial interventions [9][10][11]. Being able to have more precise information on who would respond to interventions, especially psychosocial interventions that require a weekly commitment over months, would benefit participants and not expose people to the potentially demoralising effect of attending a therapy that they were not able to benefit from [12].…”

Section: Background and Rationalementioning

confidence: 99%

Randomised controlled trial of Compensatory Cognitive Training and a Computerised Cognitive Remediation programme

Dark

Newman²,

Gore‐Jones

et al. 2020

Trials

View full text Add to dashboard Cite

Background Compensation and adaptation therapies have been developed to improve community functioning via improving neurocognitive abilities in people with schizophrenia. Various modes of delivering compensation and adaptation therapies have been found to be effective. The aim of this trial is to compare two different cognitive interventions, Compensatory Cognitive Training (CCT) and Computerised Interactive Remediation of Cognition–Training for Schizophrenia (CIRCuiTS). The trial also aims to identify if mismatch negativity (MMN) can predict an individual’s response to the compensation and adaptation programmes. Methods This study will use a randomised, controlled trial of two cognitive interventions to compare the impact of these programmes on measures of neurocognition and function. One hundred clinically stable patients aged between 18 and 65 years with a diagnosis of a schizophrenia spectrum disorder will be recruited. Participants will be randomised to either the CCT or the CIRCuiTS therapy groups. The outcome measures are neurocognition (BACS), subjective sense of cognitive impairment (SSTICS), social functioning (SFS), and MMN (measured by EEG) in people with schizophrenia spectrum disorders. Discussion This trial will determine whether different approaches to addressing the cognitive deficits found in schizophrenia spectrum disorders are of comparable benefit using the outcome measures chosen. This has implications for services where cost and lack of computer technology limit the implementation and dissemination of interventions to address cognitive impairment in routine practice. The trial will contribute to the emerging evidence of MMN as a predictor of response to cognitive interventions. Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12618000161224. Registered on 2 February 2018. Protocol version: 4.0, 18 June 2018.

show abstract

Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia

Cited by 48 publications

References 61 publications

Altered Sensorimotor-to-Transmodal Hierarchical Organization in Schizophrenia

Altered Sensorimotor-to-Transmodal Hierarchical Organization in Schizophrenia

Impaired Sensory Processing During Low-Oxygen Exposure: A Noninvasive Approach to Detecting Changes in Cognitive States

Randomised controlled trial of Compensatory Cognitive Training and a Computerised Cognitive Remediation programme

Contact Info

Product

Resources

About