Neurophysiologic Characterization of Resting State Connectivity Abnormalities in Schizophrenia Patients

Koshiyama, Daisuke; Miyakoshi, Makoto; Tanaka‐Koshiyama, Kumiko; Joshi, Yash B.; Molina, Juan L.; Sprock, Joyce; Braff, David L.; Light, Gregory A.

doi:10.3389/fpsyt.2020.608154

Cited by 10 publications

(9 citation statements)

References 58 publications

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“…The observation of increased resting-state gamma-band oscillations (RS-GBO) under the influence of ketamine parallels observations made in patients with schizophrenia ( 11 – 13 , 61 ). As elaborated in the introduction, the generation of GBO involves a neural microcircuit consisting of pyramidal cells, fast-spiking inhibitory GABA-releasing PV + -interneurons ( 23 ), and SST + -interneurons ( 28 ).…”

Section: Discussionsupporting

confidence: 73%

Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System

et al. 2021

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Disturbed functional connectivity is assumed to cause neurocognitive deficits in patients suffering from schizophrenia. A Glutamate N-methyl-D-aspartate receptor (NMDAR) dysfunction has been suggested as a possible mechanism underlying altered connectivity in schizophrenia, especially in the gamma- and theta-frequency range. The present study aimed to investigate the effects of the NMDAR-antagonist ketamine on resting-state power, functional connectivity, and schizophrenia-like psychopathological changes in healthy volunteers. In a placebo-controlled crossover design, 25 healthy subjects were recorded using resting-state 64-channel-electroencephalography (EEG) (eyes closed). The imaginary coherence-based Multivariate Interaction Measure (MIM) was used to measure gamma and theta connectivity across 80 cortical regions. The network-based statistic was applied to identify involved networks under ketamine. Psychopathology was assessed with the Positive and Negative Syndrome Scale (PANSS) and the 5-Dimensional Altered States of Consciousness Rating Scale (5D-ASC). Ketamine caused an increase in all PANSS (p < 0.001) as well as 5D-ASC scores (p < 0.01). Significant increases in resting-state gamma and theta power were observed under ketamine compared to placebo (p < 0.05). The source-space analysis revealed two distinct networks with an increased mean functional gamma- or theta-band connectivity during the ketamine session. The gamma-network consisted of midline regions, the cuneus, the precuneus, and the bilateral posterior cingulate cortices, while the theta-band network involved the Heschl gyrus, midline regions, the insula, and the middle cingulate cortex. The current source density (CSD) within the gamma-band correlated negatively with the PANSS negative symptom score, and the activity within the gamma-band network correlated negatively with the subjective changed meaning of percepts subscale of the 5D-ASC. These results are in line with resting-state patterns seen in people who have schizophrenia and argue for a crucial role of the glutamate system in mediating dysfunctional gamma- and theta-band-connectivity in schizophrenia. Resting-state networks could serve as biomarkers for the response to glutamatergic drugs or drug development efforts within the glutamate system.

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Section: Discussionsupporting

confidence: 73%

Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System

et al. 2021

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“…Interestingly, we observed that both the LORD and EROD groups together had increased ReHo in the left rolandic operculum gyrus/left superior temporal gyrus compared to HCs. The rolandic operculum gyrus and superior temporal gyrus belong to the auditory network ( Oh et al, 2018 ; Koshiyama et al, 2020 ), which has the function of integrating auditory stimuli and processing them, and is closely related to human emotions ( Phillips et al, 2001 ; Wang et al, 2019 ). Previous studies have found that depression scale scores are positively correlated with gray matter in the left rolandic operculum gyrus and left superior temporal gyrus, suggesting that these two brain regions also play a role in mood regulation ( Besteher et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Regional Homogeneity of Resting-State fMRI Between the Early-Onset and Late-Onset Recurrent Depression in Adults

Sun

Chen

et al. 2022

Front. Psychol.

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BackgroundNeurobiological mechanisms underlying the recurrence of major depressive disorder (MDD) at different ages are unclear, and this study used the regional homogeneity (ReHo) index to compare whether there are differences between early onset recurrent depression (EORD) and late onset recurrent depression (LORD).MethodsEighteen EORD patients, 18 LORD patients, 18 young healthy controls (HCs), and 18 older HCs were included in the rs-fMRI scans. ReHo observational metrics were used for image analysis and further correlation of differential brain regions with clinical symptoms was analyzed.ResultsANOVA analysis revealed significant differences between the four groups in ReHo values in the prefrontal, parietal, temporal lobes, and insula. Compared with EORD, the LORD had higher ReHo in the right fusiform gyrus/right middle temporal gyrus, left middle temporal gyrus/left angular gyrus, and right middle temporal gyrus/right angular gyrus, and lower ReHo in the right inferior frontal gyrus/right insula and left superior temporal gyrus/left insula. Compared with young HCs, the EORD had higher ReHo in the right inferior frontal gyrus/right insula, left superior temporal gyrus/left insula, and left rolandic operculum gyrus/left superior temporal gyrus, and lower ReHo in the left inferior parietal lobule, right inferior parietal lobule, and left middle temporal gyrus/left angular gyrus. Compared with old HCs, the LORD had higher ReHo in the right fusiform gyrus/right middle temporal gyrus, right middle temporal gyrus/right angular gyrus, and left rolandic operculum gyrus/left superior temporal gyrus, and lower ReHo in the right inferior frontal gyrus/right insula. ReHo in the right inferior frontal gyrus/right insula of patients with LORD was negatively correlated with the severity of 17-item Hamilton Rating Scale for Depression (HAMD-17) scores (r = −0.5778, p = 0.0120).ConclusionAdult EORD and LORD patients of different ages have abnormal neuronal functional activity in some brain regions, with differences closely related to the default mode network (DMN) and the salience network (SN), and patients of each age group exhibit ReHo abnormalities relative to matched HCs.Clinical Trial Registration[http://www.chictr.org.cn/], [ChiCTR1800014277].

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“…Subjects EEG recordings from an archival cohort of 147 healthy comparison subjects and 158 schizophrenia patients, where resting-state frequency effects and connectivity analyses were previously described, 44,45 were obtained for the present analyses. Since the groups differed in age and sex, subsamples of 128 healthy comparison subjects and 142 schizophrenia patients matched on age and sex were used.…”

Section: Methodsmentioning

confidence: 99%

“…43 Our prior studies showed that (i) resting-state gamma-band EEG power at the frontal and temporal scalp electrodes is increased in schizophrenia patients relative to healthy subjects 44 ; and (ii) that significantly increased directed connectivities in the gamma band are observed between estimated frontal and temporal source regions in schizophrenia patients relative to healthy subjects. 45 However, the underlying neural mechanisms of abnormal higher gamma-band EEG activity in schizophrenia patients remains unclear. 44,[46][47][48][49] Identification of the contributing lower frequently neural synchronization such as delta-and theta-band EEG to gamma-band EEG power abnormality at rest (i.e.…”

mentioning

confidence: 99%

High‐power gamma‐related delta phase alteration in schizophrenia patients at rest

Koshiyama

Miyakoshi

Tanaka‐Koshiyama

et al. 2022

Psychiatry Clin Neurosci

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Aim Information processing is supported by the cortico‐cortical transmission of neural oscillations across brain regions. Recent studies have demonstrated that the rhythmic firing of neural populations is not random but is governed by interactions with other frequency bands. Specifically, the amplitude of gamma‐band oscillations is associated with the phase of lower frequency oscillations in support of short and long‐range communications among networks. This cross‐frequency relation is thought to reflect the temporal coordination of neural communication. While schizophrenia patients show abnormal oscillatory responses across multiple frequencies at rest, it is unclear whether the functional relationships among frequency bands are intact. This study aimed to characterize the lower frequency (delta/theta, 1–8 Hz) phase and the amplitude of gamma oscillations in healthy subjects and schizophrenia patients at rest. Methods Low frequency‐phase (delta‐ and theta‐ band) angles and gamma‐band amplitude relationships were assessed in 142 schizophrenia patients and 128 healthy subjects. Results Significant low‐frequency phase alteration related to high‐power gamma was detected across broadly distributed scalp regions in both healthy subjects and patients. In patients, delta phase synchronization related to high‐power gamma was significantly decreased at the frontocentral, right middle temporal, and left temporoparietal electrodes but significantly increased at the left parietal electrode. Conclusions High‐power gamma‐related delta phase alteration may reflect a core pathophysiologic abnormality in schizophrenia. Data‐driven measures of functional relationships among frequency bands may prove useful in the development of novel therapeutics. Future studies are needed to determine whether these alterations are specific to schizophrenia or appear in other neuropsychiatric patient populations.

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Neurophysiologic Characterization of Resting State Connectivity Abnormalities in Schizophrenia Patients

Cited by 10 publications

References 58 publications

Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System

Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System

A Comparative Study of Regional Homogeneity of Resting-State fMRI Between the Early-Onset and Late-Onset Recurrent Depression in Adults

High‐power gamma‐related delta phase alteration in schizophrenia patients at rest

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