Neurophysiologic Advance in Depressive Disorder

Pterostilbene as a Therapeutic Alternative for Central Nervous System Disorders: A Review of the Current Status and Perspectives

“…The detailed neurobiological mechanisms underlying depression are still not well understood. In 2003, Thomas and Peterson first proposed the theory of a “neuroplasticity disorder of the hippocampus” in depression, suggesting that damage to hippocampal neurons and impaired regeneration ultimately lead to functional neurological dysfunction as a key component in the pathogenesis of depression, and this was supported by subsequent research. , Neurotrophic factors, such as BDNF, are major regulators of neuronal survival, growth, and differentiation during development and are responsible for neuroplasticity in the nervous system. , The pathogenesis of depression and the therapeutic effects of antidepressants both heavily rely on signaling through BDNF and its receptor tropomyosin-related kinase B . Antidepressant treatment has been found to increase BDNF levels in the hippocampus, providing further evidence of the importance of this neurotrophic factor in depression .…”