Neurophthalmic manifestations of giant sellar tumors in adults: Relationship between endocrine status and visual acuity profile pre and postsurgical treatment: A prospective cohort study

Uche, NJ; Uche, EO; Eze, Boniface Ikenna; Amuta, DS; Guga, DA; Okpara, Samuel

doi:10.4103/njcp.njcp_340_19

Cited by 2 publications

(4 citation statements)

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“…While previous studies have noted the impact of pituitary macroadenoma on visual impairment and hypopituitarism, few have explored whether pituitary gland function, particularly hormone secretion, influences vision recovery [18]- [20] . The current study revealed that the pituitary gland area is a significant influencing factor, with visual disturbances more likely to recover when the pituitary gland size exceeds 25 mm 2 , indicating the pituitary gland function is important for the recovery of the visual impairment.…”

Section: Discussionmentioning

confidence: 99%

A clinical practical model for preoperative prediction of visual outcome for pituitary adenoma patients in a retrospective and prospective study

Zheng,

Wang,

Wang

et al. 2024

Preprint

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Objective: Preoperative prediction of visual recovery after pituitary adenoma resection surgery remains challenging. This study aimed to investigate the value of clinical and radiological features in preoperatively predicting visual outcomes after surgery. Methods:Patients undergoing endoscopic transsphenoidal surgery (ETS) for pituitary adenoma were included in this retrospective and prospective study. Preoperative MRI, visual acuity, visual field, and postoperative visual recovery data were collected. Logistic regression analysis was used to assess the importance of clinical and MRI features, and a prediction model was developed. Results: The cohort included 198 patients (150 retrospective, 48 prospective). In the retrospective data, visual recovery was observed in 111 patients (74.0%), while non-recovery was observed in 39 patients (26.0%). In the prospective data, visual recovery was observed in 27 patients (56.25%) and non-recovery in 21 patients (43.75%). Blindness, headache, adenoma area, and adenoma upward growth distance were negatively correlated with visual recovery (p < 0.05), while the pituitary gland area was positively correlated (p = 0.001). Logistic regression selected three clinical features: blindness, headache, and visual impairment course. Two additional imaging features, pituitary gland maximum area, and adenoma maximum area, were incorporated into the prediction model. The area under the curve of the prediction model was 0.944 in the retrospective cohort and 0.857 in the prospective cohort. Accuracy was 88% and 81.25%, respectively. Conclusion: This study successfully developed a clinical practical model combining clinical and radiological features to preoperatively predict visual recovery for patients with pituitary adenoma. The model has the potential to provide personalized counseling for individual patients.

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Section: Discussionmentioning

confidence: 99%

A clinical practical model for preoperative prediction of visual outcome for pituitary adenoma patients in a retrospective and prospective study

Zheng,

Wang,

Wang

et al. 2024

Preprint

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“…Entre os tumores hipofisários, 50-80% são adenomas, tumores neuroendócrinos benignos bastante comuns, correspondentes a 15,5% de todos os tumores do sistema nervoso central (SNC) 8,9 . Eles podem ser classificados, pelo seu tamanho, em macroadenomas, a partir de 10mm, e microadenomas, quando menores, além de funcionais e não funcionais, baseado na atividade endócrina [8][9][10][11] . A incidência dos adenomas é de 3,4 casos por 100000 habitantes por ano, com pico bimodal entre 25-45 anos e 60-70 anos 9 .…”

Section: Introductionunclassified

“…Prejuízo visual pode ocorrer por aumento crônico da pressão intracraniana, mais especificamente por compressão ou invasão do tumor na via óptica 11 . Já os defeitos de campo visual -geralmente hemianopsia bitemporal -e baixa visão ocorrem em 9-32% e 4-16%, respectivamente 1 .…”

Section: Introductionunclassified

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Expanding intracranial parachiasmatic lesion simulating glaucoma: a case report and integrative literature review

Castro¹,

Castro²,

Naves³

et al. 2022

eOftalmo

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Apesar de o glaucoma ser uma neuropatia óptica bastante prevalente e cursar com o achado característico de escavação do disco óptico aumentada, outras patologias oftalmológicas também podem cursar com quadro semelhante. Dessa forma, o diagnóstico correto e precoce da etiologia da alteração ocular é de extrema importância no tratamento dos pacientes, principalmente em casos de doenças potencialmente progressivas e ameaçadoras à vida, como em neoplasias hipofisárias. O presente artigo busca relatar um caso de equívoco no diagnóstico de glaucoma em paciente com lesão expansiva intracraniana paraquiasmática e realizar uma breve discussão sobre aspectos que auxiliam no diagnóstico diferencial dessas condições.

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Neurophthalmic manifestations of giant sellar tumors in adults: Relationship between endocrine status and visual acuity profile pre and postsurgical treatment: A prospective cohort study

Cited by 2 publications

References 0 publications

A clinical practical model for preoperative prediction of visual outcome for pituitary adenoma patients in a retrospective and prospective study

A clinical practical model for preoperative prediction of visual outcome for pituitary adenoma patients in a retrospective and prospective study

Expanding intracranial parachiasmatic lesion simulating glaucoma: a case report and integrative literature review

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