Neurophotonic Vision Restoration

Bar-Noam, Adi Schejter; Shoham, Shy

doi:10.1201/9780429194702-23

Cited by 1 publication

(4 citation statements)

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“…Amongst optical neuromodulation methods, optogenetics has received considerable attention recently ( Klapper et al, 2016 ; Bar-Noam and Shoham, 2020 ; Lindner et al, 2022 ; Sakai et al, 2022 ; Parnami and Bhattacharyya, 2023 ; Stefanov and Flannery, 2023 ). Apart from photoreceptors, most mammalian neurons are not inherently sensitive to light.…”

Section: Less Invasive Neuromodulation Strategiesmentioning

confidence: 99%

“…To increase the efficacy of visual prostheses in this case, selective modulation of multiple individually-addressable RGCs may offer some advantages, since this strategy does not rely on the survival of the lower-level retinal circuitry, and the neuronal signal will be transmitted to the optic nerve directly. Bar-Noam and Shoham, 2020;Lindner et al, 2022;Sakai et al, 2022;Parnami and Bhattacharyya, 2023;Stefanov and Flannery, 2023). Apart from photoreceptors, most mammalian neurons are not inherently sensitive to light.…”

Section: The Retina and Its Degenerationmentioning

confidence: 99%

“…While the topic of retinal stimulation strategies to restore vision has been thoroughly reviewed ( Yue et al, 2016 ; Bar-Noam and Shoham, 2020 ; Farnum and Pelled, 2020 ; Nowik et al, 2020 ; Shim et al, 2020 ; Ayton et al, 2020a ) and there are several broad-based reviews for optical neuromodulation ( Richter et al, 2011 ; Thompson et al, 2014 ; Richardson et al, 2020 ; Park et al, 2021 ; Jiang et al, 2022 ; Karatum et al, 2023 ) and nanoparticle-mediated neuromodulation ( Wang and Guo, 2016 ; Paviolo and Stoddart, 2017 ; Wang Y. C. et al, 2018 ; Ledesma et al, 2019 ; Li et al, 2021 ; Benfenati and Lanzani, 2021a ; Shi et al, 2022 ; Yang et al, 2023 ), none of these have discussed optically-mediated, nanoparticle-based techniques in the specific context of the retina. A recent review by Liu et al (2022) was primarily concerned with the application of nanotechnology in implantable interfaces, whereas the focus here is on nanoparticles as a minimally-invasive optical interface.…”

Section: Introductionmentioning

confidence: 99%

“…We note that optically-responsive nanoparticle-based approaches remain broadly compatible with existing head-mounted cameras, light projection goggles and signal processing capacity that have been developed in support of bioelectronic ( Ayton et al, 2020b ) or optogenetic approaches ( Reutsky-Gefen et al, 2013 ; Sahel et al, 2021 ). The requirements for light projection and image processing to appropriately encode information to the retina for correct interpretation in the visual cortex have been comprehensively discussed ( Bar-Noam and Shoham, 2020 ). Therefore, we instead focus here on the outstanding pharmacokinetic challenges that relate to nanoparticle delivery and cell-specific targeting in the retina.…”

Section: Introductionmentioning

confidence: 99%

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Nanoparticle-based optical interfaces for retinal neuromodulation: a review

Stoddart,

Begeng,

Tong

et al. 2024

Front. Cell. Neurosci.

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Degeneration of photoreceptors in the retina is a leading cause of blindness, but commonly leaves the retinal ganglion cells (RGCs) and/or bipolar cells extant. Consequently, these cells are an attractive target for the invasive electrical implants colloquially known as “bionic eyes.” However, after more than two decades of concerted effort, interfaces based on conventional electrical stimulation approaches have delivered limited efficacy, primarily due to the current spread in retinal tissue, which precludes high-acuity vision. The ideal prosthetic solution would be less invasive, provide single-cell resolution and an ability to differentiate between different cell types. Nanoparticle-mediated approaches can address some of these requirements, with particular attention being directed at light-sensitive nanoparticles that can be accessed via the intrinsic optics of the eye. Here we survey the available known nanoparticle-based optical transduction mechanisms that can be exploited for neuromodulation. We review the rapid progress in the field, together with outstanding challenges that must be addressed to translate these techniques to clinical practice. In particular, successful translation will likely require efficient delivery of nanoparticles to stable and precisely defined locations in the retinal tissues. Therefore, we also emphasize the current literature relating to the pharmacokinetics of nanoparticles in the eye. While considerable challenges remain to be overcome, progress to date shows great potential for nanoparticle-based interfaces to revolutionize the field of visual prostheses.

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