Neuropharmacology and Drug Interactions in Clinical Practice

Graves, Nina M.

doi:10.1111/j.1528-1157.1995.tb05997.x

Cited by 15 publications

(2 citation statements)

References 19 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…39 Clinicians should realize that drug interactions can occur when therapy is discontinued as well as when drugs are initiated. 40 For example, valproic acid is an enzyme inhibitor. If it is discontinued, the concentration of the drug it interacts with will decrease.…”

Section: Patients Should Not Experience Drug Interactionsmentioning

confidence: 99%

Antiepileptic Drug Treatment: Outcomes and Adherence

Garnett

2000

Pharmacotherapy

View full text Add to dashboard Cite

The goal in treating patients with epilepsy is a cost-effective approach to the elimination of seizures or a reduction in their number and frequency while avoiding drug interactions and side effects, so as to achieve the best possible quality of life. Among the desirable outcomes are an enhanced understanding of epilepsy by patients, caregivers, and society, and a lessening of the psychosocial risks of this disease. Patients fail to achieve their goals and outcomes when they fail to adhere to the drug regimen or when a less-than-adequate drug regimen is prescribed. To help improve adherence, once- or twice-daily formulations should be used. New antiepileptic drugs (AEDs) increase the possibility of effective treatment for a patient who initially fails therapy. Working together, patients and clinicians can maximize the effectiveness of AED therapy and the potential for achieving desired goals and outcomes.

show abstract

Section: Patients Should Not Experience Drug Interactionsmentioning

confidence: 99%

Antiepileptic Drug Treatment: Outcomes and Adherence

Garnett

2000

Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…3641 In addition, these patients are frequently treated with multiple other medications which may interact with the anti-epileptic drugs. 42 " 44 This may also result in pharmacodynamic interactions which lead to side effects or seizures. 41 Drug toxicity may become more difficult to evaluate and manage under these circumstances.…”

Section: Change In Medical Conditionmentioning

confidence: 99%

Monotherapy versus Polytherapy in Epilepsy: a Framework for Patient Management

1998

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

ABSTRACT:The long-standing debate between proponents of monotherapy and those of polytherapy for treatment of epilepsy has been rekindled by the recent development of several new antiepileptic drugs. The likelihood of improved seizure control on polytherapy must be weighed against the risk of increased side effects, complex drug interactions and cost. Providing maximal seizure control while avoiding overtreatment is a challenge which requires an ongoing critical evaluation of each patient's management. This review provides a framework for decision-making by considering issues affecting the choice between monotherapy and polytherapy in five clinical situations: 1) newly diagnosed epilepsy; 2) seizures on monotherapy; 3) seizures controlled on polytherapy; 4) not controlled on polytherapy; 5) change in medical condition. RESUME: La monotherapie versus la polytherapie dans Pepilepsie: un cadre pour le traitement des patients. Le vieux debat entre les promoteurs de la monotherapie et ceux de la polytherapie dans le traitement de Pepilepsie a ete repris a cause du developpement recent de plusieurs nouveaux medicaments antiepileptiques. La probability d'un meilleur controle des crises par une polytherapie doit etre evaluee par rapport au risque d'effets secondaires plus importants, d'interactions medicamenteuses complexes et du cout de la medication. C'est un d6fi que d'arriver a un controle maximal des crises tout en evitant de surtraiter, ce qui demande une evaluation critique constante du traitement de chaque patient. Cette revue fournit un cadre pour la prise de decision en considerant les raisons qui influencent le choix entre la monotherapie et la polytherapie dans cinq situations cliniques: 1) un nouveau diagnostic d'epilepsie; 2) des crises sous monotherapie; 3) un controle des crises sous polytherapie; 4) une absence de controle sous polytherapie; 5) un changement dans l'etat medical du patient.Can. J. Neurol. Sci. 1998; 25: S9-S13

show abstract

Anfallsleiden

Besser¹,

Schwalen

2002

Neurologische Therapie

View full text Add to dashboard Cite

Neuropharmacology and Drug Interactions in Clinical Practice

Cited by 15 publications

References 19 publications

Antiepileptic Drug Treatment: Outcomes and Adherence

Antiepileptic Drug Treatment: Outcomes and Adherence

Monotherapy versus Polytherapy in Epilepsy: a Framework for Patient Management

Anfallsleiden

Contact Info

Product

Resources

About