Neuropharmacological screening of essential oil from oleo gum resin of Gardenia lucida Roxb

Shareef, Mohammad Zubair; Yellu, Narsimha Reddy; Achanta, V.N. Appa Rao

doi:10.1016/j.jep.2013.07.004

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…Both the myrcene and limonene chemotypes of Lippia alba increase the latency period and survival of mice with PTZ-induced seizures [56]. The alpha-pinene rich resin of Gardenia lucida prolongs pentobarbital hypnosis and protects against intensity and frequency of seizures and animal mortality in PTZ and MES models, with loss of motor function as a side effect [47].…”

Section: Resultsmentioning

confidence: 99%

The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review

Bahr

Rodriguez²,

Beaumont³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Many essential oils (EOs) have anticonvulsant activity and might benefit people with epilepsy. Lemongrass, lavender, clove, dill, and other EOs containing constituents such as asarone, carvone, citral, eugenol, or linalool are good candidates for evaluation as antiepileptic drugs. On the other hand, some EOs have convulsant effects and may trigger seizures in both epileptic and healthy individuals. Internal use of EOs like sage, hyssop, rosemary, camphor, pennyroyal, eucalyptus, cedar, thuja, and fennel can cause epileptic seizures because they contain thujone, 1,8-cineole, camphor, or pinocamphone, which have been identified as convulsive agents. While more research is needed to confirm their mechanisms of action, it appears that the convulsant or anticonvulsant properties of essential oils are largely due to (1) their ability to modulate the GABAergic system of neurotransmission and (2) their capacity to alter ionic currents through ion channels. This review presents a systematic analysis of the current research on EOs and epilepsy, including human case studies, animal models, andin vitrostudies.

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Section: Resultsmentioning

confidence: 99%

The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review

Bahr

Rodriguez²,

Beaumont³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Some studies suggest neuropharmacological activities for G. lucida essential oil from this gum-resin (GLEO). At a lethal dose it caused the death of 50% of a group of test animals (LD 50 ) greater than 5 mL/kg, yet without showing toxicological signs [67]. GS/MS analysis revealed the presence of 18 constituents, of which α-pinene (45%) and spathulenol (31%) were the main components.…”

Section: Gardenia Lucida Roxbmentioning

confidence: 99%

“…Alfa-and beta-pinene are two bicyclic monoterpenes with isomeric chemical structure found in the chemical composition of many essential oils [44,67,82]. Felipe et al [122] evaluated the anticonvulsant effect of the two isolated terpenes as well as the racemic mixture.…”

Section: Alpha-and Beta-pinenementioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

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Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

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Development and Validation of UPLC–PDA Method for Quality Control of Dikamali gum—A Natural Tablet Binder: Fast Simultaneous Quantitation of Six Polymethoxyflavones

et al. 2018

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Neuropharmacological screening of essential oil from oleo gum resin of Gardenia lucida Roxb

Cited by 9 publications

References 19 publications

The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review

The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

Development and Validation of UPLC–PDA Method for Quality Control of Dikamali gum—A Natural Tablet Binder: Fast Simultaneous Quantitation of Six Polymethoxyflavones

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