Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin — A mini-review

Roohbakhsh, Ali; Parhiz, Hamideh; Soltani, Fatemeh; Rezaee, Ramin; Iranshahi, Mehrdad

doi:10.1016/j.lfs.2014.07.029

Cited by 155 publications

(97 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hesperidin and its aglycone, hesperetin, are two flavonoids that are very common in citrus species with various biological properties. Hesperidin possesses vitamin‐like activity and can decrease capillary permeability (vitamin P), leakiness and fragility . It also showed anti‐oxidant, anti‐inflammatory, anti‐carcinogenic and anti‐allergic properties …”

Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

et al. 2019

View full text Add to dashboard Cite

BACKGROUND The Cerrado occupies 23% of Brazil. A. othonianum is a native Cerrado species that presents differently colored pseudofruits. This report describes the morphometric properties, physicochemical characterization, and phenolic and flavonoid compound compositions of 30 accessions of A. othonianum. RESULTS The morphometric properties show that an average fruit had 21.97 mm length, 18.61 mm width, and 11.13 mm thickness, with 2.52 g mass. The pseudofruits had 28.84 mm apex width with 12.83 g of mass. The hue parameters of the pseudofruits were 18.67 ± 2.00 and 83.32 ± 1.97° (P < 0.05), reflecting their red to yellow color. The titratable acidity of the accessions was 0.91 ± 0.09 to 3.02 ± 0.02% (P < 0.05), soluble solid content was 9.60 ± 0.17 to 13.47 ± 0.38 °Brix (P < 0.05), and pH ranged from 2.83 ± 0.06 to 3.83 ± 0.06 (P < 0.05). Fourteen flavonoid compounds were identified. The most common compounds in the accessions were vitexin (93% of the accessions), hesperidin (57% of the accessions), epicatechin (34% of the accessions), and kaempferol‐3‐O‐glucoside (30% of the accessions). Cluster analysis generated four groups with the traits ΔE, °h, C, soluble solid content, titratable acidity, pH, total flavonoids, and their identified compounds. CONCLUSIONS Although all accessions are A. othonianum, there the chemical composition and the physical characteristics of these fruits vary. This is the first report in the literature using wild accessions. Greater disclosure of the species characteristic is interesting because it can increase income for the local population. © 2019 Society of Chemical Industry

show abstract

Section: Resultsmentioning

confidence: 99%

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

et al. 2019

View full text Add to dashboard Cite

show abstract

“…HP has various biological effects such as anticancer, neuroprotective, antioxidant and anti-inflammatory properties (Roohbakhsh et al 2014). Further studies have to be conducted to explore more aspects of the beneficial effects of HP in human diseases.…”

Section: Discussionmentioning

confidence: 99%

Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling

Hong

2015

Arch. Pharm. Res.

View full text Add to dashboard Cite

Numerous studies have demonstrated that oxidative stress and inflammation play a pivotal role in the pathophysiology of Alzheimer disease (AD). Hesperidin (HP) has various pharmacological effects including anti-oxidative, anti-inflammatory and neuroprotective properties. In this study, APP/PS1 mice were used to evaluate the neuroprotective effects of HP. We reported that intragastric administration of HP (40 mg/kg) for 90 days significantly attenuated cognitive impairment in APP/PS1 mice. HP treatment suppressed oxidative stress by reducing the levels of ROS, LPO, protein carbonyl and 8-OHdG and increasing the activity of HO-1, SOD, catalase, and GSH-Px. HP treatment also inhibited inflammation by decreasing the levels of TNF-α, C-reactive protein and MCP-1 and reducing the activity of NF-κB. Moreover, HP could reverse the decreased phosphorylation of Akt, the decreased phosphorylation of GSK-3β, the lessened Nrf2 and the reduced expression of HO-1. HP could also inhibit the increased the RAGE expression, the enhanced phosphorylation of IκBα, and the augmented nuclear translocation of NF-κB/p65 in cortex of APP/PS1 mice. Taken together, HP suppresses oxidative stress and inflammation via activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling and further confers neuroprotection.

show abstract

“…It has been well documented that Hypericum perforatum, a "modern" herbal antidepressant, exerts extensive anti-inflammatory activities including the inhibitory activity on TNF-α, IL-1β, and LPS-induced prostaglandin E2 (Huang et al, 2011;Hammer and Birt, 2014). Recently, there is significant attention focused on the antidepressant-like effect of flavonoids extracted from herb medicines (González-Cortazar et al, 2013;Huerta-Reyes et al, 2013;Lv et al, 2014;Roohbakhsh et al, 2014;Reis et al, 2014), and it is notable that anti-inflammatory effect is also one of the primary biological activities of flavonoids (Tuñón et al, 2009;Shalini et al, 2012). Therefore, we may speculate that the anti-inflammatory effect of these herbs is possibly related to their antidepressant-like effect.…”

Section: Discussionmentioning

confidence: 99%

Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice

Liu

et al. 2015

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin — A mini-review

Cited by 155 publications

References 60 publications

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling

Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice

Contact Info

Product

Resources

About