Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats

Gelfuso, Erica Aparecida; Cunha, Alexandra Olímpio Siqueira; Mortari, Márcia Renata; Liberato, José Luiz; Paraventi, Karina Haddad; Beleboni, Renê Oliveira; Coutinho‐Netto, Joaquim; Lopes, Norberto Peporine; Santos, Wagner Ferreira dos

doi:10.1016/j.lfs.2006.10.002

Cited by 24 publications

(23 citation statements)

References 29 publications

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“…Compounds with anticonvulsant activity were found also in venom from other arthropods such as spiders. [3839]…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista

Couto¹,

Anjos²,

Araujo³

et al. 2012

Phcog Mag

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Background:Arthropod venoms have attracted interest because they represent a source of neuroactive compounds that can be useful tools in neuroscience and pharmacological investigations.Objective:The purpose of the present work was to evaluate the anticonvulsant, anxiolytic, and behavioral effects of the peptide fraction separated from venom of the social wasp.Materials and Methods:The low- molecular-weight compounds of the venom were separated by ultrafiltration and the bioassays were performed to test anticonvulsant and anxiolytic effects, as well as alterations in the spontaneous behavior of the animals.Results:Intracerebroventricular injections of the compounds induced dose-dependent anticonvulsant effects and a potent anxiolytic activity. Regarding behavioral effects, no significant differences were observed in relation to the saline control group.Conclusion:The low-molecular-weight compounds of the venom of Polybia paulista include neuroactive peptides that can be used as pharmacological resources for anticonvulsant and anxiolytic drug research.

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“…Compounds with anticonvulsant activity were found also in venom from other arthropods such as spiders. [3839]…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista

Couto¹,

Anjos²,

Araujo³

et al. 2012

Phcog Mag

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“…In addition, the administration of Parawixin II into the vitreous humor of Wistar rats protected retinal neurons against ischemic insult resulted from an increase in the intra ocular pressure [96]. Data also show that Parawixin II blocked seizures induced by the injection of GABAergic antagonists, bicuculline [99], pentylenetetrazole (PTZ) and picrotoxin, as well as pilocarpine and kainic acid [100]. It is worth noting that the acute injection of Parawixin II does not alter rat behavior in the open field and repeated central injection does not impair acquisition and learning in the Morris water maze.…”

Section: Antiepileptic and Neuroprotective Effectsmentioning

confidence: 98%

“…It is worth noting that the acute injection of Parawixin II does not alter rat behavior in the open field and repeated central injection does not impair acquisition and learning in the Morris water maze. Finally, Parawixin II induces ataxia in the rotarod in doses far higher than effective doses, indicating good therapeutic indexes [100].…”

Section: Antiepileptic and Neuroprotective Effectsmentioning

confidence: 98%

New Perspectives in Drug Discovery Using Neuroactive Molecules From the Venom of Arthropods

Mortari¹,

Cunha²

2013

An Integrated View of the Molecular Recognition and Toxinology - From Analytical Procedures to Biomedical Applications

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“…Outro composto isolado, a FrPbA2, apresenta, seletivamente, um potente efeito inibitório sobre a recaptação do GABA e da glicina, além de ser anticonvulsivante contra crises agudas induzidas pela bicuculina (CAIRRÃO et al, 2002), picrotoxina, pilocarpina, ácido caínico e PTZ, sem induzir toxicidade motora na dose efetiva (GELFUSO et al, 2007). Mais recentemente, a estrutura química desse composto foi elucidada juntamente com parte do seu mecanismo de ação.…”

Section: Neurotoxinas Antinociceptivasunclassified

Neurotoxinas: Perspectivas para a descoberta de novos analgésicos

Ferreira¹,

Mortari²

2008

Univ. Ci. Saúde

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ResumoA dor é um fenômeno complexo, estando, muitas vezes, associada a condições limitantes. Muitas manifestações neuropáticas, as quais têm como sintoma sensação dolorosa intensa, continuam, ainda, sem tratamento. Em diversas outras patologias, quando há a disponibilidade, os efeitos colaterais constituem fatores de limitação para a terapia crônica. Vários estudos apontam para uma grande variedade de substratos neurais que podem ser alvos de intervenção farmacológica no controle da dor. Nesse contexto, as neurotoxinas derivadas de venenos de animais fornecem uma fonte vasta e, até certo ponto, inexplorada de compostos neuroativos. Dessa forma, o objetivo do presente trabalho foi o de descrever as neurotoxinas atualmente estudadas que podem ser utilizadas na prática clínica para o controle da dor.Palavras-chave: Dor. Analgésicos. Neurotoxinas. IntroduçãoHá milhões de anos, durante um contínuo processo evolutivo, vários animais invertebrados têm desenvolvido um conjunto de substâncias com atividade biológica nos seus venenos, que são usadas, principalmente, para paralisarem presas e/ou defender-se contra predadores.Quando inoculados em seres humanos, esses venenos podem induzir reações alérgicas e diversas alterações do Sistema Nervoso Central (SNC), como sonolência, paralisia e convulsões. Essas substâncias que têm atividade sobre o SNC 1 Bióloga, Doutora em Psicobiologia (USP). Professora da UnB, Distrito Federal, Brasil. 2 Médico, Doutor em Genética (USP). Professor do UniCEUB e da Faculdade LS, Distrito Federal, Brasil. email: Luzitano-ferreira@uol.com.br.

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Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats

Cited by 24 publications

References 29 publications

Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista

Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista

New Perspectives in Drug Discovery Using Neuroactive Molecules From the Venom of Arthropods

Neurotoxinas: Perspectivas para a descoberta de novos analgésicos

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