1987
DOI: 10.1111/j.1476-5381.1987.tb11318.x
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Neuropharmacological and neurochemical properties of N‐(2‐cyanoethyl)‐2‐phenylethylamine, a prodrug of 2‐phenylethylamine

Abstract: 1 N-(2-cyanoethyl)-2-phenylethylamine (CEPEA) was examined as a possible prodrug of 2-phenylethylamine (PEA). 2 Pharmacokinetics of PEA and CEPEA were investigated in rat brain, blood and liver by gas chromatography with electron-capture detection (GC-ECD). Interactions of PEA and CEPEA with putative neurotransmitter amines were investigated by use of high performance liquid chromatography with electrochemical detection (h.p.l.c.-e.c.). 3 Administration of PEA caused transient increases in PEA concentrations w… Show more

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Cited by 57 publications
(13 citation statements)
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References 43 publications
(27 reference statements)
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“…A portion (990 l) of the resultant supernatant was mixed with 10 l of 10% (V/V) sodium disulfite solution and aliquots of 30 l for catecholamines (NA, DA) and 20 l for 5-HT were used for high pressure liquid chromatography (HPLC) analysis. Concentrations of the amines and their metabolites were determined by HPLC with electrochemical detection, using a modification of the procedure of Baker et al (1987). A set of standards was carried through the procedure in parallel with each assay run.…”
Section: Measurement Of Whole Brain Biogenic Concentrationsmentioning
confidence: 99%
“…A portion (990 l) of the resultant supernatant was mixed with 10 l of 10% (V/V) sodium disulfite solution and aliquots of 30 l for catecholamines (NA, DA) and 20 l for 5-HT were used for high pressure liquid chromatography (HPLC) analysis. Concentrations of the amines and their metabolites were determined by HPLC with electrochemical detection, using a modification of the procedure of Baker et al (1987). A set of standards was carried through the procedure in parallel with each assay run.…”
Section: Measurement Of Whole Brain Biogenic Concentrationsmentioning
confidence: 99%
“…CSF tryptophan and the amine metabolites HVA, MHPG and 5-HI-AA were measured by reverse phase high-pressure liquid chromatography with electrochemical and fluorometric detection (Anderson et al 1979(Anderson et al , 1981. Plasma levels of tyrosine and tryptophan were analyzed using HPLC with electrochemical detection, as described by Baker et al (1987). Plasma levels of the large neutral amino acids (LNAAs) were analyzed by the gas chromatographic procedure of Wong et al (1990).…”
Section: Administration Of Amino Acid Mixturesmentioning
confidence: 99%
“…High-pressure liquid chromatography with electrochemical detection (HPLC-EC) was used to determine brain levels of NE, DA, and 5-HT. The HPLC-EC method and apparatus used are described in detail by Baker et al (1987). GABA levels were determined using gas chromatography with electron-capture detection after the amino acids were converted into their N-isobutyloxycarbonyl pentafluorophenyl ester derivatives as described by Wong and colleagues (1990a).…”
Section: Neurochemical Analysismentioning
confidence: 99%