Neuropharmacological and neurochemical properties of N‐(2‐cyanoethyl)‐2‐phenylethylamine, a prodrug of 2‐phenylethylamine

Baker, Glen B.; Coutts, Ronald T.; Rao, Tadimeti S.

doi:10.1111/j.1476-5381.1987.tb11318.x

Cited by 57 publications

(13 citation statements)

References 43 publications

(27 reference statements)

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“…A portion (990 l) of the resultant supernatant was mixed with 10 l of 10% (V/V) sodium disulfite solution and aliquots of 30 l for catecholamines (NA, DA) and 20 l for 5-HT were used for high pressure liquid chromatography (HPLC) analysis. Concentrations of the amines and their metabolites were determined by HPLC with electrochemical detection, using a modification of the procedure of Baker et al (1987). A set of standards was carried through the procedure in parallel with each assay run.…”

Section: Measurement Of Whole Brain Biogenic Concentrationsmentioning

confidence: 99%

Antidepressant-like effects in various mice strains in the forced swimming test

David¹,

Renard²,

Jolliet³

et al. 2003

Psychopharmacology

165

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Our study showed that drug sensitivity is genotype dependent. FST results have shown that Swiss mice are the most sensitive strain to detect 5-HT and/or NA treatment. The use of DBA/2 inbred mice may be limited, as an absence of antidepressant-like response was observed in the FST. The lack of sensitivity to antidepressant treatment in DBA/2 strains could be due to high DA, NA and 5-HT whole brain concentrations.

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Section: Measurement Of Whole Brain Biogenic Concentrationsmentioning

confidence: 99%

Antidepressant-like effects in various mice strains in the forced swimming test

David¹,

Renard²,

Jolliet³

et al. 2003

Psychopharmacology

165

View full text Add to dashboard Cite

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“…CSF tryptophan and the amine metabolites HVA, MHPG and 5-HI-AA were measured by reverse phase high-pressure liquid chromatography with electrochemical and fluorometric detection (Anderson et al 1979(Anderson et al , 1981. Plasma levels of tyrosine and tryptophan were analyzed using HPLC with electrochemical detection, as described by Baker et al (1987). Plasma levels of the large neutral amino acids (LNAAs) were analyzed by the gas chromatographic procedure of Wong et al (1990).…”

Section: Administration Of Amino Acid Mixturesmentioning

confidence: 99%

An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys

et al. 1998

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An amino acid mixture devoid of tryptophan, given orally, was previously shown to reduce cerebrospinal fluid levels of tryptophan and 5-hydroxyindoleacetic acid in vervet monkeys, as compared to a control mixture containing all essential amino acids. In the present study, we tested the possibility that a similar amino acid mixture containing tryptophan, but devoid of phenylalanine and tyrosine (the amino acid precursors of catecholamine neurotransmitters), would influence dopamine and noradrenaline metabolism. Five hours after the administration of this mixture to vervet monkeys, cerebrospinal fluid levels of homovanillic acid and 3-methoxy-4-hydroxyphenylethylene glycol were reduced by 27.4% and 26.9%, respectively. Both effects were statistically significant. Plasma tyrosine (-30%) and the ratio of tyrosine to the sum of other large neutral amino acids (sigmaLNAA) were also significantly reduced. The behavioral efficacy of phenylalanine/tyrosine depletion was compared with that of tryptophan depletion in a primate model of voluntary alcohol consumption. All three drinks lowered alcohol consumption, but the effects of the tryptophan-deficient amino acid mixture were not different from those of the balanced amino acid control. The phenylalanine/tyrosine-deficient drink differentially lowered alcohol consumption, consistent with other data in this species and elsewhere implicating dopamine in the rewarding effects of alcohol.

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“…High-pressure liquid chromatography with electrochemical detection (HPLC-EC) was used to determine brain levels of NE, DA, and 5-HT. The HPLC-EC method and apparatus used are described in detail by Baker et al (1987). GABA levels were determined using gas chromatography with electron-capture detection after the amino acids were converted into their N-isobutyloxycarbonyl pentafluorophenyl ester derivatives as described by Wong and colleagues (1990a).…”

Section: Neurochemical Analysismentioning

confidence: 99%

Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory

1999

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Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive evidence implicating biogenic amines and GABA in mnemonic processes, PLZ may affect learning and memory. To investigate this possibility, male Sprague-Dawley rats were given PLZ sulfate (15 or 30 mg/kg, based on free base weight) 2 h prior to training in a continuous multiple trial inhibitory avoidance (CMIA) and spatial water maze task. Retention was assessed 48 h later. The results indicated that PLZ enhanced CMIA and impaired water maze retention performance. Compared to control rats, rats given PLZ took significantly longer to re-enter the shock compartment and swam longer distances before reaching the escape platform on the retention tests. These effects of PLZ did not appear to be the result of PLZ-induced changes in acquisition or retrieval processes, activity levels, or footshock sensitivity. Combined, these findings indicate that PLZ influences memory in a task-dependent manner. These differential effects of PLZ may be the result of contrasting influences of GABA and biogenic amines on memory.

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Neuropharmacological and neurochemical properties of N‐(2‐cyanoethyl)‐2‐phenylethylamine, a prodrug of 2‐phenylethylamine

Cited by 57 publications

References 43 publications

Antidepressant-like effects in various mice strains in the forced swimming test

Antidepressant-like effects in various mice strains in the forced swimming test

An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys

Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory

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