Neuropharmacological and acute toxicological evaluation of ethanolic extract of Allamanda cathartica L. flowers and plumieride

Bonomini, Tiago José; Holzmann, Iandra; Thiesen, Liliani Carolini; Fratoni, Eduarda; Muller, Ana Flavia Fischer; Lucinda-Silva, Ruth Meri; Yunes, Rosendo A.; Malheiros, Ângela; Gonçalves, Ana Elisa; Dalmagro, Ana Paula; Silva, Kathryn Ana Bortolini Simão da; Souza, Márcia María de; Santin, José Roberto

doi:10.1016/j.yrtph.2017.10.005

Cited by 13 publications

(9 citation statements)

References 37 publications

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“…[ 43–46 ] Plumieridine can be obtained by enzymatic hydrolysis of plumieride, as previously described. [ 17 ] Several biological activities of plumieride have been described: such as antifungal against dermatophytes [ 47,48 ] and phytopathogens, [ 49 ] antidepressant‐like, [ 50 ] and immunostimulatory activities. [ 51 ] The MIC and MFC values of plumieride and plumieridine were higher than the MIC values of ASEAP, with the exception of MFC of plumieridine for C. neoformans H99.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

Bresciani

Santi

Beys‐da‐Silva

et al. 2020

Archiv der Pharmazie

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Cryptococcosis, caused by Cryptococcus spp., is an invasive fungal infection of the central nervous system, associated with high mortality, affecting mainly immunocompromised patients. Due to the development of resistance to the current therapy, there is an urgent need for less toxic and more effective antifungal agents. In this study, we describe the antifungal activity against Cryptococcus spp. of an aqueous seed extract from Allamanda polyantha (ASEAP) and two iridoids, plumieride and plumieridine, isolated from this extract with an antifungal activity. The capsule formation and the morphological alterations were evaluated using fluorescent microscopy. The cytotoxic activity was also investigated. The minimal inhibitory concentration (MIC) values of ASEAP for Cryptococcus gattii were 70 and 36 µg/ml (for the R265 and R272 strains, respectively) and 563 µg/ml for Cryptococcus neoformans H99. ASEAP inhibited C. neoformans H99 capsule formation, an important virulence factor, and decreased the cell body size for both the C. gattii strains. H99 cells also presented morphological alterations, with defects in bud detachment and nuclear fragmentation. Plumieride and plumieridine presented higher MIC values than ASEAP, indicating that other compounds might contribute to antifungal activity and/or that combination of the compounds results in a higher antifungal activity.

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Section: Discussionmentioning

confidence: 99%

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

Bresciani

Santi

Beys‐da‐Silva

et al. 2020

Archiv der Pharmazie

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“…2.1 PLANT MATERIAL AND ISOLATION OF PLUMIERIDE PLU was isolated from Allamanda cathartica flowers, and its purity (>98%) was verified by HPLC and NMR analysis, according to our previous studies (BONOMINI et al, 2017;MULLER et al, 2015). PLU was dissolved only in distilled water for oral administration.…”

Section: Methodsmentioning

confidence: 99%

“…Noteworthy, a recent study published by our research group indicate that PLU was responsible for antidepressant-like effect after an acute intraperitoneal administration in female mice evaluated in Forced Swimming Test (FST), at 1 µg/Kg; besides its low toxicity and high solubility in water (BONOMINI et al, 2017;SINGH et al, 2017). However, evidence has shown that anti-inflammatory and antidepressant effects may be linked to the antioxidant capacity of some compounds (SLAVICH; IRWIN, 2014).…”

Section: Introductionmentioning

confidence: 99%

Modulation of nitro-oxidative parameters in mice administered with very low doses of the iridoid plumieride

Dalmagro

Camargo

Zimath

et al. 2020

BJHR

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ABCTRACT Key words: Plumieride; iridoid; Allamanda cathartica; oxidative stress. RESUMONosso grupo de pesquisa tem investigado os efeitos anti-inflamatório e tipo-antidepressivo do plumierídeo (PLU -0,5, 1 e 2 µg/Kg). Contudo, não há evidências na literatura científica quanto a atividade antioxidante do PLU quando usado em doses extremamente baixas, que podem ser relacionados aos seus efeitos farmacológicos. Neste estudo, foi administrado PLU (0,5, 1 e 2 µg/Kg) à camundongos durante 7 dias. Posteriormente, nós avaliados a capacidade do PLU em modular a lipoperoxidação, nitritos, carbonilação de proteínas e tióis não-proteicos no cérebro, plasma, fígado e rins dos camundongos. Nossos resultados fundamentam, pelo menos em parte, o potencial farmacológico que tem sido atribuído ao iridoide.Palavras-chave: Plumierídeo; iridoide; Allamanda cathartica; estresse oxidativo.

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“…and the compound ( 145 ) (0.5, 1, and 2 mg/kg, i.p.) decreased the total and High Density Lipoprotein (HDL) cholesterol levels, with significant differences of p < 0.001 and p < 0.05, respectively, in female Swiss Webster mice at the two highest doses tested [61].…”

Section: Pharmacological Activitymentioning

confidence: 99%

“…in mice, it was observed that the LD 50 was 1320 ± 15 mg/kg [28]. The oral administration of 2 mg/kg of ethanolic extract of flowers and the compound ( 145 ) in Swiss Webster mice administered as a single dose and evaluated at 14 days showed no toxic effects, no changes in biochemical or haematological parameters, and no genotoxic effects [61]. The toxicological evaluation of the petroleum ether extract of leaves in albino mice showed no toxicity at doses of 100 to 1000 mg/kg p.o.…”

Section: Toxicitymentioning

confidence: 99%

Allamanda cathartica: A Review of the Phytochemistry, Pharmacology, Toxicology, and Biotechnology

Petricevich

Abarca-Vargas

2019

Molecules

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In this work, we explore the current knowledge about the phytochemistry and in vitro and in vivo evaluations of the extracts and, where appropriate, the main active components characterized and isolated from the Allamanda cathartica. Of the 15 Allamanda species, most phytochemical, pharmacological, and toxicological studies have focused on A. cathartica. These plants are used for the treatment of various health disorders. Numerous phytochemical investigations of plants from the A. cathartica have shown the presence of hydrocarbons, alcohols, esters, ethers, aldehydes, ketones, fatty acids, phospholipids, volatile compounds, phenolic compounds, flavonoids, alkaloids, steroids, terpenes, lactones, and carbohydrates. Various studies have confirmed that extracts and active substances isolated from the A. cathartica have multiple pharmacological activities. The species A. cathartica has emerged as a source of traditional medicine used for human health. Further studies on the phytochemical, pharmacological, and toxicological properties and their mechanisms of action, safety, and efficacy in the species of A. cathartica is recommended.

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Neuropharmacological and acute toxicological evaluation of ethanolic extract of Allamanda cathartica L. flowers and plumieride

Cited by 13 publications

References 37 publications

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

Modulation of nitro-oxidative parameters in mice administered with very low doses of the iridoid plumieride

Allamanda cathartica: A Review of the Phytochemistry, Pharmacology, Toxicology, and Biotechnology

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