Neuropharmacological activities of ethanol leaf extract of &lt;i&gt;Cussonia barteri&lt;/i&gt; Seeman (Araliaceae) in laboratory animals

Yakubu, Musa Itopa; Anuka, JA; Chindo, Ben Ahmed; Magaji, Mohammed Garba; Abbas, Medinat Yakubu

doi:10.4314/jpb.v16i1.4

Cited by 2 publications

(7 citation statements)

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“…Photomicrographs of heart showed no gross architectural abnormalities at all doses of extract. The extract had a dose-dependent effect on the histopathology of the kidney, liver and lungs, while 100 mg/kg caused no abnormalities, 200 and 400 mg/kg produced hyperplasia and congestion with hepatic and tubular necrosis [39]. USA).…”

Section: Toxicological Evaluationsmentioning

confidence: 95%

“…(glucose, L-rhamnose, L-arabinose and o-xylose) and hederagenin as aglucones [38]. The ethanol extract of leaves contains flavonoids, saponins, steroids, tannins, glycosides and carbohydrates [39]. Preliminary screening of n-hexane extract of seeds and seed marc reported the presence of flavonoids, tannins, and glycosides and alkaloids.…”

Section: Some Isolated Compounds and Their Biological Activitiesmentioning

confidence: 99%

“…Yakubu [39] demonstrated the acute and subacute toxicities of ethanol leaf extract in Swiss albino mice and Wistar rats. Using the method of Lorke [46], Yakubu reported the LD 50 after i.p.…”

Section: Toxicological Evaluationsmentioning

confidence: 99%

“…The ethnomedicinal use of C. barteri in mental disorders led to evaluation for anticonvulsant actitvity by Yakubu [39]. Mice and fifty (50) day old white cockerels were used for this study.…”

Section: Anticonvulsant Studiesmentioning

confidence: 99%

“…Behavioral studies on the ethanol leaf extract [39] were performed using the diazepam-induced sleeping time [56], hole board test [57], mouse beam walking assay [58] and open field test [59] in experimental animals. The onset and duration of diazepam-induced sleeping time was significantly (p<0.05) increased by 200 and 400 mg/kg.…”

Section: Neurobehavioral Evaluationsmentioning

confidence: 99%

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Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review

2018

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Summary Cussonia barteri Seem (Araliaceae) is a deciduous tree growing in savannah of Africa. Ethnomedicinally, it is used in Africa as an analgesic, anti-malarial, anti-inflammatory, anti-anaemic, anti-diarhoea, anti-poison, ani-pyschotic and anti-epileptic agent. This review provides a brief summary on the phytochemical screenings, ethnomedicinal and pharmacological applications of various parts of C. barteri. Leaves, stem bark and seed of C. barteri have been shown to be rich in saponins, flavonoids, phenols, sugars and alkaloids. Some of these constituents have been isolated and elucidated from C. barteri. Several compounds isolated from plant include triterpenes, saponins, polyenyne and quinic esters. Phytochemical constituents are also partly responsible for biological activities of C. barteri. Extracts and components isolated from the plant have demonstrated neuropharmacological, anti-larvicidal, anti-microbial, anti-inflammatory and antioxidant activities. Overall, the insights provided by this review reinforce the potential of C. barteri for drug development and create the need for further scientific probe of constituents of the plant with the aim of developing novel drug candidates.

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Section: Toxicological Evaluationsmentioning

confidence: 95%

Section: Some Isolated Compounds and Their Biological Activitiesmentioning

confidence: 99%

Section: Toxicological Evaluationsmentioning

confidence: 99%

Section: Anticonvulsant Studiesmentioning

confidence: 99%

Section: Neurobehavioral Evaluationsmentioning

confidence: 99%

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Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review

2018

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The anti-seizure and anti-nociceptive potential of hexane fraction from the leaves of Detarium senegalense

Nwachukwu¹,

Akuodor²,

ILO³

et al. 2022

Magna Sci. Adv. Res. Rev.

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Detarium senegalense, J.F. Gmelin (Fabaceae) is used in Nigerian folk medicine to treat different diseases including epilepsy, microbial infections, gastrointestinal diseases and inflammation; its efficacy is widely acclaimed among communities in South Eastern Nigeria. This study aimed to evaluate the anti-seizure and anti-nociceptive potential of hexane fraction from the leaves of D. senegalense The hexane fraction of D. senegalense leaf was evaluated to determine the effect of the oral administration of the extract (100 – 400 mg/kg) against seizure using the pentylenetetrazole (PTZ), brucine, isoniazid (INH) induced seizure models and analgesic activity using the writhing and water tail immersion tests in mice. The hexane fraction of the extract significantly (p<0.05) increased the latency period in seizures induced by PTZ, brucine and isoniazid, and significantly reduced the duration of seizures induced by these three inducing agents. The extract also protected 67 % of animals against death. In acetic acid-induced writhing models and tail immersion models, the fraction showed a good analgesic effect characterized by a significant (p<0.05 – p<0.01) reduction in the number of writhes when compared to the control and a significant (p<0.05 – p<0.01 increase in the latency in a dose-related manner. The findings of the present study validated the folkloric use of Detarium senegalense leaves in seizure disorders as well as painful conditions.

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Neuropharmacological activities of ethanol leaf extract of <i>Cussonia barteri</i> Seeman (Araliaceae) in laboratory animals

Cited by 2 publications

References 0 publications

Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review

Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review

The anti-seizure and anti-nociceptive potential of hexane fraction from the leaves of Detarium senegalense

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