Neuropeptides in Dental Pulp: The Silent Protagonists

Expression of substance P, calcitonin gene-related peptide, β-endorphin and methionine-enkephalin in human dental pulp tissue after orthodontic intrusion: A pilot study

“…0.05). Such an increase was noted when irreversible pulpitis was diagnosed 17,26 after 10 minutes of induced pulp inflammation 27 and after orthodontic stimulation. 29 When considered together, it must be remembered that both are known to be collocated within the same sensory nonmyelinated fiber, a fact corroborated by evidence that demonstrated that an increased density of both nerve-containing fibers is found in the dental pulp of mechanically stressed teeth.…”

“…The increase of SP coincided with reports of a higher expression in symptomatic cases of irreversible pulpitis 17,21,26 and cases in which inflammation was induced, such as deep restorative cavities, the use of certain whitening systems, and the placement of adhesives for cervical preparations. 27 Specifically, a greater immunoreactive presence of SP on cats' teeth was reported when orthodontic movement was applied. 28 CGRP expression levels were also higher but were not significantly different (P .…”

Inflammation–regeneration interplay in the dentine–pulp complex

“…74,75 Indeed, the role of several neuropeptides in pulpal disease pathogenesis is now well recognised and studies have thus far examined the roles of a range of these molecules within the pulp including calcitonin (CT), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP) and vasoactive intestinal polypeptide (VIP) elsewhere. 76 Whilst the release of these molecules within the pulp is also involved in the development of dental pain, several of these molecules have also been shown to be able to stimulate regenerative dentinogenic events. Indeed SP, CGRP, VIP and NPY may represent novel regulators of pulpal angiogenic events whilst CGRP and CT stimulated osteodentin deposition in ferret canines.…”

Effect of Experimentally Induced Occlusal Trauma on Substance P Expression in Human Dental Pulp and Periodontal Ligament

“…Substance P (SP) is capable of triggering vasodilation, plasma extravasation, immune system activation, chemotaxis, and recruitment and/or regulation of inflammatory cells such as macrophages, mast cells, and lymphocytes (7). Finally, the release of inflammatory mediators in the tissue generates vascular stasis in the affected area (3,8).…”