Neuropeptides as regulators of the hypothalamus-pituitary-gonadal (HPG) axis activity and their putative roles in stress-induced fertility disorders

Gołyszny, Miłosz; Obuchowicz, Ewa; Zielinski, Michal W.

doi:10.1016/j.npep.2021.102216

Cited by 21 publications

(12 citation statements)

References 269 publications

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“…For hormone secretion, an inhibitory action of SPX1 on the plasma LH level was observed in goldfish and Nile tilapia ( 12 , 14 ) along with a reduction of plasma FSH level in the latter. Interestingly, SPX1 evoked a decrease in the serum LH level, but an increase in the serum FSH level in mature female rats ( 55 ). Of note, SPX2 had no effect on gh expression in this study.…”

Section: Discussionmentioning

confidence: 97%

New evidence for SPX2 in regulating the brain-pituitary reproductive axis of half-smooth tongue sole (Cynoglossus semilaevis)

Wang

Tian

et al. 2022

Front. Endocrinol.

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Spexin (SPX) is an evolutionarily conserved neuropeptide, which was first identified in human proteome by data mining. Two orthologs (SPX1 and SPX2) are present in some non-mammalian species, including teleosts. It has been demonstrated that SPX1 is involved in reproduction and food intake, whereas the functional role of SPX2 is still absent in any vertebrate. The aim of the current study was to evaluate the actions of intraperitoneal injection of endogenous SPX2 peptide on the expression levels of some key reproductive genes of the brain-pituitary axis in half-smooth tongue sole. Our data showed an inhibitory action of SPX2 on brain gnih, spx1, tac3 and pituitary gthα, lhβ mRNA levels. However, SPX2 had no significant effect on brain gnihr, gnrh2, gnrh3, kiss2, kiss2r, spx2 expression or pituitary gh expression. On the other hand, SPX2 induced an increase in pituitary fshβ expression. Taken together, our results provide initial evidence for the involvement of SPX2 in the regulation of reproduction in vertebrates, which is in accordance with previous studies on SPX1.

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Section: Discussionmentioning

confidence: 97%

New evidence for SPX2 in regulating the brain-pituitary reproductive axis of half-smooth tongue sole (Cynoglossus semilaevis)

Wang

Tian

et al. 2022

Front. Endocrinol.

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“…This was further supported by the use of discriminant analysis where AV levels were able to better classify individuals into the different social‐experience groups than oxytocin levels. The effects of the oxytocin‐AV system might involve up‐ or downstream interactions with other endocrine systems, given the two nonapeptides are linked with the regulation and feedback control of both the HPA axis (and HPI axis in fish) and the HPG axis 59–61 …”

Section: Social Dominance: Winner‐loser Dynamics and Assessment Mecha...mentioning

confidence: 99%

Social zebrafish:Danio rerioas an emerging model in social neuroendocrinology

Kareklas

Teles

Nunes

et al. 2023

J Neuroendocrinology

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The fitness benefits of social life depend on the ability of animals to affiliate with others and form groups, on dominance hierarchies within groups that determine resource distribution, and on cognitive capacities for recognition, learning and information transfer. The evolution of these phenotypes is coupled with that of neuroendocrine mechanisms, but the causal link between the two remains underexplored. Growing evidence from our research group and others demonstrates that the tools available in zebrafish, Danio rerio, can markedly facilitate progress in this field. Here, we review this evidence and provide a synthesis of the state‐of‐the‐art in this model system. We discuss the involvement of generalized motivation and cognitive components, neuroplasticity and functional connectivity across social decision‐making brain areas, and how these are modulated chiefly by the oxytocin‐vasopressin neuroendocrine system, but also by reward‐pathway monoamine signaling and the effects of sex‐hormones and stress physiology.

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“…Phoenixin (PNX) exists in two isoforms: PNX-14 and PNX-20, which consist of 14 and 20 amino acids, respectively. Both are coupled with G-protein-coupled receptor-173 (GPR173) [ 277 ]. Jiang et al described its dose-dependent anxiolytic-like behavior in a male Kunming strain of Swiss mice [ 278 ].…”

Section: Neuropeptides In Anxiety and Depressionmentioning

confidence: 99%

“…Later, in research using restraint stress in Sprague Dawley rats, Friedrich et al were able to prove that phoenixin expression in the dorsal motor nucleus of the vagus nerve, raphe pallidus, and nucleus of the solitary tract positively correlated with C-fos expression in these nuclei in response to restraint stress [ 282 ]. A recent review also suggests that PNX modulates the HPA axis during chronic stress [ 277 ]. There are also human studies indicating the role of phoenixin-14 in the modulation of anxiety.…”

Section: Neuropeptides In Anxiety and Depressionmentioning

confidence: 99%

Anxiety and Depression: What Do We Know of Neuropeptides?

Kupcová

Danišovič

Grgac

et al. 2022

Behavioral Sciences

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In modern society, there has been a rising trend of depression and anxiety. This trend heavily impacts the population’s mental health and thus contributes significantly to morbidity and, in the worst case, to suicides. Modern medicine, with many antidepressants and anxiolytics at hand, is still unable to achieve remission in many patients. The pathophysiology of depression and anxiety is still only marginally understood, which encouraged researchers to focus on neuropeptides, as they are a vast group of signaling molecules in the nervous system. Neuropeptides are involved in the regulation of many physiological functions. Some act as neuromodulators and are often co-released with neurotransmitters that allow for reciprocal communication between the brain and the body. Most studied in the past were the antidepressant and anxiolytic effects of oxytocin, vasopressin or neuropeptide Y and S, or Substance P. However, in recent years, more and more novel neuropeptides have been added to the list, with implications for the research and development of new targets, diagnostic elements, and even therapies to treat anxiety and depressive disorders. In this review, we take a close look at all currently studied neuropeptides, their related pathways, their roles in stress adaptation, and the etiology of anxiety and depression in humans and animal models. We will focus on the latest research and information regarding these associated neuropeptides and thus picture their potential uses in the future.

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Neuropeptides as regulators of the hypothalamus-pituitary-gonadal (HPG) axis activity and their putative roles in stress-induced fertility disorders

Cited by 21 publications

References 269 publications

New evidence for SPX2 in regulating the brain-pituitary reproductive axis of half-smooth tongue sole (Cynoglossus semilaevis)

New evidence for SPX2 in regulating the brain-pituitary reproductive axis of half-smooth tongue sole (Cynoglossus semilaevis)

Social zebrafish:Danio rerioas an emerging model in social neuroendocrinology

Anxiety and Depression: What Do We Know of Neuropeptides?

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