Neuropeptides as lung cancer growth factors

Moody, Terry W.; Moreno, Paola; Jensen, Robert T.

doi:10.1016/j.peptides.2015.03.018

Cited by 19 publications

(26 citation statements)

References 74 publications

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“…GRPR, is overexpressed by a large number of tumors including tumors of the prostate, breast, colon, CNS(gliomas, meningiomas), lung including non-small-cell-lung-cancer(NSCLC), small-cell-lung-cancer(SCLC)], head/neck-squamous-cell-tumors, pancreatic-cancer, and neuroblastomas[1,23, 24•,–25]. NMBR is also frequently overexpressed in neoplasms including by tumors of the lung (NSCLC, SCLC), pancreas, colon and carcinoids (bronchial, intestinal)[1,23].…”

Section: General: Grp-nmb and Bnr’s In Tumorsmentioning

confidence: 99%

“…BRS-3 is found in neuroendocrine tumors, tumors of the lung, pancreas, pituitary, ovary and prostate[23,26]. GRP and NMB stimulate the growth and/or differentiation of a wide range of cancers, and studies suggest GRP functions as an autocrine-growth-factor in a number of tumors, whereas in other tumors, such as colon-cancer, it has weak growth effects, and functions primarily as a morphogen[2••,24•,25,27]. Recent studies demonstrate in a number of different tumors(neuroendocrine, lung, prostate, head/neck-squamous-tumors) that activation of GRPR, NMBR, BRS-3 resulting in growth responses are frequently mediated by transactivation of tumor EGFR or HER2[28•,29–31].…”

Section: General: Grp-nmb and Bnr’s In Tumorsmentioning

confidence: 99%

“…This occurred because small-cell-lung-cancers(SCLC) have long been known to produce and secrete Bn-like-peptides[24•,25] and in 1985 it was the first human-tumor in which an autocrine-growth effect was shown[33]. In addition to synthesizing Bn-related-peptides, lung-cancers frequently possess BnR’s.…”

Section: Bn-peptides-bnr: Lung-cancermentioning

confidence: 99%

“…Activation of each of the three BnR-receptor subtypes on lung-cancer-cell-lines stimulates growth/proliferation[24•,25,29] and activation of BRS-3 stimulates increased adhesion of tumor-cells. Recent studies demonstrate that transactivation of the EGF-receptor on lung-cancer-cells is a key mechanism for the stimulation of lung-cancer cell-proliferation by activation of each of the three BnR-subtypes[2••,28•,29,31].…”

Section: Bn-peptides-bnr: Lung-cancermentioning

confidence: 99%

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Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Moreno

Ramos-Álvarez

Moody

et al. 2016

Expert Opinion on Therapeutic Targets

Self Cite

102

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Introduction Despite remarkable advances in tumor treatment, many patients still die from common tumors (breast, prostate, lung, CNS, colon, and pancreas), and thus, new approaches are needed. Many of these tumors synthesize bombesin (Bn)-related peptides and over-express their receptors (BnRs), hence functioning as autocrine-growth-factors. Recent studies support the conclusion that Bn-peptides/BnRs are well-positioned for numerous novel antitumor treatments, including interrupting autocrine-growth via the use of over-expressed receptors for imaging and targeting cytotoxic-compounds, either by direct-coupling or combined with nanoparticle-technology. Areas covered The unique ability of common neoplasms to synthesize, secrete, and show a growth/proliferative/differentiating response due to BnR over-expression, is reviewed, both in general and with regard to the most frequently investigated neoplasms (breast, prostate, lung, and CNS). Particular attention is paid to advances in the recent years. Also considered are the possible therapeutic approaches to the growth/differentiation effect of Bn-peptides, as well as the therapeutic implication of the frequent BnR over-expression for tumor-imaging and/or targeted-delivery. Expert opinion Given that Bn-related-peptides/BnRs are so frequently ectopically-expressed by common tumors, which are often malignant and become refractory to conventional treatments, therapeutic interventions using novel approaches to Bn-peptides and receptors are being explored. Of particular interest is the potential of reproducing BnRs in common tumors, such as the recent success of utilizing overexpression of somatostatin-receptors by neuroendocrine-tumors to provide the most sensitive imaging methods and targeted delivery of cytotoxic-compounds.

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Section: General: Grp-nmb and Bnr’s In Tumorsmentioning

confidence: 99%

Section: General: Grp-nmb and Bnr’s In Tumorsmentioning

confidence: 99%

Section: Bn-peptides-bnr: Lung-cancermentioning

confidence: 99%

Section: Bn-peptides-bnr: Lung-cancermentioning

confidence: 99%

See 2 more Smart Citations

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Moreno

Ramos-Álvarez

Moody

et al. 2016

Expert Opinion on Therapeutic Targets

Self Cite

102

View full text Add to dashboard Cite

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“…Transactivation requires phospholipase-C, not adenylate-cyclase, but stimulation of matrix-melloproteinases, Src-kinases, TGF-alpha release and generation of oxygen-free-radicals[55]. With other GPCR's(bombesin, neurotensin)[95••, 96••, 97] inducing growth in lung-cancer-cells, the simultaneous inhibition of the GPCR by an antagonist and a tyrosine-kinase-inhibitor(gefitinib, etc) leads to potentiated growth-inhibitory effects. These findings raise the possibility that a similar stragey could be consider with VIP/PACAP-receptors on these tumor-cells.…”

Section: Vip/pacap: Lung-cancermentioning

confidence: 99%

Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Moody¹,

Nuche-Berenguer

Jensen

2016

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

Self Cite

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Purpose of review To summarize the roles of VIP/PACAP and their receptors(VPAC1, VPAC2/PAC1) in human tumors as well as their role in potential novel treatments. Recent findings Considerable progress has been made in understanding of the effects of VIP/PACAP on growth of various tumors as well as in the signaling cascades involved, especially of the role of transactivation of the Epidermal growth factor(EGF) family. The overexpression of VPAC1/2, PAC1 on a number of common neoplasms (breast, lung, prostate, CNS, neuroblastoma) is receiving increased attention both as a means of tumor imaging the location and extent of these tumors, as well as for targeted directed treatment, by coupling cytotoxic agents to VIP/PACAP analogues. Summary VIP/PACAP has prominent growth effects on a number of common neoplasms, which frequently overexpressed the three subtypes of their receptors. The increased understanding of their signaling cascades, effect on tumor growth/differentiation, and the use of the overexpression of these receptors for localization/targeted cytotoxic delivery, are all suggesting possible novel tumor treatments.

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Vasoactive intestinal peptide inhibits the activation of murine fibroblasts and expression of interleukin 17 receptor C

Zhang

Sun

et al. 2019

Cell Biology International

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Acute respiratory distress syndrome (ARDS) is an acute, severe, and refractory pulmonary inflammation with high morbidity and mortality. Excessive activation of fibroblast during the fibroproliferative phase plays a pivotal role in the prognosis of ARDS. Our previous study demonstrated that the vasoactive intestinal peptide (VIP) is mediated by lentivirus attenuates lipopolysaccharide (LPS)‐induced ARDS in a murine model, and VIP inhibits the release of interleukin‐17A (IL‐17A) from activation macrophages. However, the effects of VIP on the activation of murine fibroblast and expression of IL‐17 receptor (IL‐17R) in ARDS remain unclear. Here, a mouse model of ARDS was established by an intratracheal injection of LPS. We found that the gene expression of col3a1 and hydroxyproline contents in the lungs were significantly increased 24 h after LPS injection. IL‐17RC rather than IL‐17RA was increased in the lungs of mice with ARDS. In vitro, LPS activated NIH3T3 cells, which was suppressed by VIP in a dose‐dependent manner. In detail, VIP reduced the hydroxyproline content and col3a1 messenger RNA induced by LPS in NIH3T3 cells, as well as the expression of α‐smooth muscle actin. Furthermore, we found that VIP inhibited the expression of IL‐17R in the lungs of mice with ARDS and NIH3T3 cells stimulated with LPS, which was partly inhibited by antagonists of protein kinase A and protein kinase C. Taken together, our results demonstrated that VIP inhibited the activation of fibroblast via downregulation of IL‐17RC, which may contribute to the protective effects of VIP against ARDS in mice.

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Neuropeptides as lung cancer growth factors

Cited by 19 publications

References 74 publications

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Vasoactive intestinal peptide inhibits the activation of murine fibroblasts and expression of interleukin 17 receptor C

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