Neuropeptide Y (NPY) in tumor growth and progression: Lessons learned from pediatric oncology

Tilan, Jason U.; Kitlińska, Joanna

doi:10.1016/j.npep.2015.10.005

Cited by 48 publications

(70 citation statements)

References 108 publications

(254 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NPY is widely expressed in the central and peripheral nervous system, influencing via its Y receptors many physiological processes, such as cortical excitability, stress and immune response, food intake, circadian rhythms, cardiovascular function, glucose metabolism. NPY is also involved in biology of some tumors, controlling angiogenesis, tumor growth, metastasis and cancer cell metabolism [84]. An in vitro study revealed that Y1 and Y2 receptors are present in the androgen-independent human PC-3 cell line and that their activation by NPY stimulates cancer cell proliferation, which suggests its impact on castration-resistant regulation of PC [83,85].…”

Section: Nt In Pcmentioning

confidence: 99%

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

et al. 2020

View full text Add to dashboard Cite

The tumor microenvironment (TME) plays an essential role in the development and progression of neoplasms. TME consists of the extracellular matrix and numerous specialized cells interacting with cancer cells by paracrine and autocrine mechanisms. Tumor axonogenesis and neoneurogenesis constitute a developing area of investigation. Prostate cancer (PC) is one of the most common malignancies in men worldwide. During the past years, more and more studies have shown that mechanisms leading to the development of PC are not confined only to the epithelial cancer cell, but also involve the tumor stroma. Different nerve types and neurotransmitters present within the TME are thought to be important factors in PC biology. Moreover, perineural invasion, which is a common way of PC spreading, in parallel creates the neural niche for malignant cells. Cancer neurobiology seems to have become a new discipline to explore the contribution of neoplastic cell interactions with the nervous system and the neural TME component, also to search for potential therapeutic targets in malignant tumors such as PC.

show abstract

Section: Nt In Pcmentioning

confidence: 99%

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As such it modulates many physiological functions ranging from stress responses, food intake, reproduction, circadian rhythms, anxiety and depression and pain processing (64). It exerts its principal activities through neuropeptide receptors 1, 2 and 5 and in the context of cancer (65), much information has been learned from two pediatric diseases with high endogenous NPY production-neuroblastoma and Ewing sarcoma-that have become models to investigate the role of NPY in tumor growth and progression (66). However, NPY and its receptor have been found to be expressed in cells and vasculatures from a variety of tumors (65) where they exert complex effects.…”

Section: Npymentioning

confidence: 99%

“…However, NPY and its receptor have been found to be expressed in cells and vasculatures from a variety of tumors (65) where they exert complex effects. It is generally accepted that NPY is an angiogenic factor, which strongly induces the endothelial cell proliferation, differentiation and migration, and promotes vascularization (66). Aside from being synthesized in tumor cells, NPY is also released systemically from sympathetic neurons (67).…”

Section: Npymentioning

confidence: 99%

“…While there are no significant reported side effects associated with the administration of NPY receptor antagonists in animals and people (34), the potential anorexigenic effects of NPY receptor blockage in cancer patients would have to be carefully monitored. Moreover, the use of a brainimpenetrable receptor antagonist could prevent such adverse central effects, while preserving peripheral activities on tumor growth and metastasis (66).…”

Section: Npymentioning

confidence: 99%

See 1 more Smart Citation

Tumor progression: the neuronal input

et al. 2018

View full text Add to dashboard Cite

One of the challenges of cancer is its heterogeneity and rapid capacity to adapt. Notwithstanding significant progress in the last decades in genomics and precision medicine, new molecular targets and therapies appear highly necessary. One way to approach this complex problem is to consider cancer in the context of its cellular and molecular microenvironment, which includes nerves. The peripheral nerves, the topic of this review, modulate the biological behavior of the cancer cells and influence tumor progression, including the events related to the metastatic spread of the disease. This mechanism involves the release of neurotransmitters directly into the microenvironment and the activation of the corresponding membrane receptors. While this fact appears to complicate further the molecular landscape of cancer, the neurotransmitters are highly investigated molecules, and often are already targeted by well-developed drugs, a fact that can help finding new therapies at a fraction of the cost and time needed for new medicines (through the so-called drug repurposing). Moreover, the modulation of tumor progression by neurotransmitters can probably explain the long-recognized effects of psychological factors on the burden of cancer. We begin with an introduction on the tumor-nervous-connections and a description of the perineural invasion and neoneurogenesis, the two most important interaction patterns of cancer and nerves. Next, we discuss the most recent data that unequivocally demonstrate the necessity of the nervous system for tumor onset and growth. We introduce the molecular players of the tumor-nervous-connections by citing the role of three main families: neurotropic factors, axon guidance molecules, and neurotransmitters. Finally, we review the role the most important neurotransmitters in tumor biology and we conclude by analyzing the significance of the presented data for cancer therapy, with all the potential advantages and caveats.

show abstract

“…While well regarded as an orexigenic peptide in the brain, NPY functions in many other aspects of physiology, such as learning and memory, 102 tumor growth and progression, 103 and other processes related to adipose tissue. The effects of NPY that are related to adipose tissue and energy balance are summarized in Table 2 and Figure 1.…”

Section: Adipose Physiology: Npymentioning

confidence: 99%

Recent advances in the understanding of how neuropeptide Y andα-melanocyte stimulating hormone function in adipose physiology

2016

View full text Add to dashboard Cite

Communication between the brain and the adipose tissue has been the focus of many studies in recent years, with the "brain-fat axis" identified as a system that orchestrates the assimilation and usage of energy to maintain body mass and adequate fat stores. It is now well-known that appetiteregulating peptides that were studied as neurotransmitters in the central nervous system can act both on the hypothalamus to regulate feeding behavior and also on the adipose tissue to modulate the storage of energy. Energy balance is thus partly controlled by factors that can alter both energy intake and storage/expenditure. Two such factors involved in these processes are neuropeptide Y (NPY) and a-melanocyte stimulating hormone (a-MSH). NPY, an orexigenic factor, is associated with promoting adipogenesis in both mammals and chickens, while a-MSH, an anorexigenic factor, stimulates lipolysis in rodents. There is also evidence of interaction between the 2 peptides. This review aims to summarize recent advances in the study of NPY and a-MSH regarding their role in adipose tissue physiology, with an emphasis on the cellular and molecular mechanisms. A greater understanding of the brain-fat axis and regulation of adiposity by bioactive peptides may provide insights on strategies to prevent or treat obesity and also enhance nutrient utilization efficiency in agriculturally-important species.

show abstract

Neuropeptide Y (NPY) in tumor growth and progression: Lessons learned from pediatric oncology

Cited by 48 publications

References 108 publications

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

Tumor progression: the neuronal input

Recent advances in the understanding of how neuropeptide Y andα-melanocyte stimulating hormone function in adipose physiology

Contact Info

Product

Resources

About