Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Duarte-Neves, Joana; Almeida, Luís Pereira de; Cavadas, Cláudia

doi:10.1016/j.nbd.2016.07.022

Cited by 103 publications

(96 citation statements)

References 313 publications

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“…Such deregulation affects body weight, food intake, sleep patterns (Nixon et al, ), and could contribute to progression of age‐related pathologies, such as Parkinson's disease (Wienecke et al, ) and Alzheimer's disease (Slats et al, ). Therefore, orexin system represents a promising target for pharmacological therapies (Duarte‐Neves, de Almeida, & Cavadas, ; Tsuneki et al, ). Previous studies suggest that NPY system is also linked to the aging process; however, its role has not been completely clarified.…”

Section: Introductionmentioning

confidence: 99%

Age‐related central regulation of orexin and NPY in the short‐lived African killifish Nothobranchius furzeri

Montesano

Baumgart

Avallone

et al. 2019

J of Comparative Neurology

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Orexin A (OXA) and neuropeptide Y (NPY) are two hypothalamic neuropeptides involved in the regulation of feeding behavior and food intake in all vertebrates. Accumulating evidences document that they undergo age-related modifications, with consequences on metabolism, sleep/wake disorders and progression of neurodegenerations. The present study addressed the age related changes in expression and distribution of orexin A (its precursor is also known as hypocretin-HCRT) and NPY, and their regulation by food intake in the short-lived vertebrate model Nothobranchius furzeri. Our experiments, conducted on male specimens, show that: (a) HCRT and OXA and NPY mRNA and protein are localized in neurons of diencephalon and optic tectum, as well as in numerous fibers projecting through the entire neuroaxis, and are colocalized in specific nuclei; (b) in course of aging, HCRT and NPY expressing neurons are localized also in telencephalon and rhombencephalon; (c) HCRT expressing neurons increased slightly in the diencephalic area of old animals and in fasted animals, whereas NPY increased sharply; (d) central HCRT levels are not regulated neither in course of aging nor by food intake; and (e) central NPY levels are augmented in course of aging, and regulated by food intake only in young. These findings represent a great novelty in the study of central orexinergic and NPY-ergic systems in vertebrates', demonstrating an uncommon and unprecedented described regulation of these two orexigenic neuropeptides. K E Y W O R D S aging, food intake, HCRT, hypothalamus, NPY, RRID:AB_1566510, RRID:AB_653610, RRID: AB_91545, teleost fish Abbreviations: A, anterior thalamic nucleus; Cans, ansulate commissure; CI, interpeduncular body; Cmin, minor commissure; CN, cortical nucleus; CP, central posterior thalamic nucleus; CPN, central pretectal nucleus; Cpost, posterior commissure; DAO, dorsal accessory optic nuclei; Dc, central zone of dorsal telencephalon; DIL, inferior lobe of hypothalamus; Dld, dorso-lateral zone of dorsal telencephalon; Dll, latero-lateral zone of dorsal telencephalon; Dlv, ventro-lateral zone of dorsal telenceph-

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Section: Introductionmentioning

confidence: 99%

Age‐related central regulation of orexin and NPY in the short‐lived African killifish Nothobranchius furzeri

Montesano

Baumgart

Avallone

et al. 2019

J of Comparative Neurology

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“…NPY is one of the most abundant neuropeptides within the brain and exerts (through its receptors, named Y1 to 6) an important role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, cognition, stress response, neurogenesis, and neuroprotection [6, 55–58]. …”

Section: Neuropeptidergic Systems In Autophagymentioning

confidence: 99%

“…Finally, NPY exerted a neuroprotective effect in the striatum and cerebellum of two mouse models of the spinocerebellar ataxia type 3 [61], a disease characterised by autophagic defects. Authors thus suggested that this action may be related to an activation of protein clearance mechanisms such as autophagy, even though additional data are mandatory to support this hypothesis [58, 61]. Overall, the potential of NPY to delay neurodegeneration through autophagy stimulation as a strategy to clear abnormal, misfolded proteins that cause neurodegenerative diseases deserves to be investigated in detail.…”

Section: Neuropeptidergic Systems In Autophagymentioning

confidence: 99%

Current Evidence for a Role of Neuropeptides in the Regulation of Autophagy

Catalani

Palma

Perrotta

et al. 2017

BioMed Research International

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Neuropeptides drive a wide diversity of biological actions and mediate multiple regulatory functions involving all organ systems. They modulate intercellular signalling in the central and peripheral nervous systems as well as the cross talk among nervous and endocrine systems. Indeed, neuropeptides can function as peptide hormones regulating physiological homeostasis (e.g., cognition, blood pressure, feeding behaviour, water balance, glucose metabolism, pain, and response to stress), neuroprotection, and immunomodulation. We aim here to describe the recent advances on the role exerted by neuropeptides in the control of autophagy and its molecular mechanisms since increasing evidence indicates that dysregulation of autophagic process is related to different pathological conditions, including neurodegeneration, metabolic disorders, and cancer.

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“…AD is the most frequent type of dementia that occurs in middle to late life [29]. It is characterized by widespread neurodegeneration throughout the basal forebrain, cortex, and limbic system as a result of neuronal and synaptic loss [30].…”

Section: Adult Neurogenesis In Alzheimer Diseasementioning

confidence: 99%

“…PD is the second most common neurodegenerative disorder after AD [29]. PD is well known as a progressive, chronic neurodegenerative disease causing motor disorders such as hypokinesia, rigidity, tremor, and postural instability as well as exhibiting nonmotor symptoms including depression, anxiety, cognitive and olfactory deficits, and autonomic dysfunction [30].…”

Section: Adult Neurogenesis In Parkinson Diseasementioning

confidence: 99%

Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function

2016

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Neurological diseases such as Alzheimer, Parkinson, and ischemic stroke have increased in occurrence and become important health issues throughout the world. There is currently no effective therapeutic strategy for addressing neurological deficits after the development of these major neurological disorders. In recent years, it has become accepted that adult neural stem cells located in the subventricular and subgranular zones have the ability to proliferate and differentiate in order to replace lost or damaged neural cells. There have been many limitations in the clinical application of both endogenous and exogenous neurogenesis for neurological disorders. However, many studies have investigated novel mechanisms in neurogenesis and have shown that these limitations can potentially be overcome with appropriate stimulation and various approaches. We will review concepts related to possible therapeutic strategies focused on the perspective of neurogenesis for the treatment of patients diagnosed with Alzheimer disease, Parkinson disease, and ischemic stroke based on current reports.

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Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Cited by 103 publications

References 313 publications

Age‐related central regulation of orexin and NPY in the short‐lived African killifish Nothobranchius furzeri

Age‐related central regulation of orexin and NPY in the short‐lived African killifish Nothobranchius furzeri

Current Evidence for a Role of Neuropeptides in the Regulation of Autophagy

Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function

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