Neuropeptide-Y, leptin and ghrelin levels in children with ADHD: effects of methylphenidate treatment

Demirci, Esra; Şan, Zejnep Lushi; Irmak, Ayşe; Özmen, Sevgi; Kilic, Eser

doi:10.5455/apd.289575

Cited by 1 publication

(1 citation statement)

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“…Studies linking adipocytokines to youth mental health are more limited, but warrant further exploration. Metabolic proteins have been associated with neurodevelopmental disorders (Ashwood et al., 2008; Demirci et al., 2018), anxiety‐related disorders (Atmaca et al., 2002; Byrne et al., 2019), and depressive symptoms (Oddy et al., 2018) in youth. However, the majority of this literature has been cross‐sectional in nature and conflicting with regard to directionality.…”

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confidence: 99%

Metabolic proteins at birth predict early childhood mental health symptoms

Scott

Manczak

2022

Developmental Psychobiology

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Child mental health disorders are the leading cause of disability in children and adolescents worldwide. Biological correlates predict psychosocial outcomes throughout human development; however, less is known about metabolic proteins. Drawing from a longitudinal birth cohort study, Born in Bradford (BiB), we examined the role of infant metabolic proteins at birth in predicting early childhood mental health symptoms at 3 and 5 years. We found that higher leptin predicted more prosocial behavior at age 3. Additionally, a higher leptin‐to‐adiponectin ratio predicted increased total symptom difficulties. At age 5, we found that higher adiponectin predicted a decreased likelihood of being rated by teachers as meeting or exceeding expectations in the domain of “managing feelings and behaviors” and marginally predicted lower competency in “making relationships” on national developmental milestone evaluations. To our knowledge, this is among the first few studies to prospectively predict mental health symptoms from cord blood metabolic proteins, and the first examining this association with a leptin‐to‐adiponectin ratio. Our results provide support for the possibility that metabolic proteins at birth forecast risk for mental health symptoms in early childhood.

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