Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia

Oxidative Stress and Nerve Function After Cardiopulmonary Bypass in Patients With Diabetes

“…This observation is corroborated by previous studies that have shown the reduction in neurotransmitters and sympathetic nerves as a possible mechanism for neuropathy in diabetes [6]. Decreased nerve growth results in decreased NPY, which is considered the "master switch" for angiogenesis and cardiac remodeling under stress and ischemia [9,25].…”

“…Compared with a normal state, there are fewer sympathetic nerves and reduced neurotransmitter concentrations, particularly neuropeptide Y (NPY), in myocardial cells from patients with diabetes [7,8]. Consequently, the protective effect of neurotransmitters (decreased apoptosis and increased angiogenesis) in response to myocardial ischemia is attenuated [9,10].…”

“…Similarly, local infiltration of NPY in chronically ischemic myocardium has been shown to increase nerve growth, enhance angiogenesis, and reduce apoptosis and fibrosis in animal models of metabolic syndrome [9,12]. Nerve growth factor (NGF) gene therapy improves sensory and sympathetic innervation in the hearts of animals with diabetes [13][14][15].…”

Long-Term Administration of Neuropeptide Y in the Subcutaneous Infusion Results in Cardiac Dysfunction and Hypertrophy in Rats

“…In the present study, we focused on the chronic effect of NPY on a normal rat model and demonstrated that exogenous administration of NPY could impair cardiac function, suggesting that the elevated plasma NPY might participate in the regulation of heart function. Interestingly there is a conflicting report that NPY improved myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia [42]. In the light of plasma NPY being increased in patients with multiple diseases [6][7][8][9][10][11], we hypothesize that NPY has bidirectional impacts on cardiac function.…”

Neuropeptide Y damages the integrity of mitochondrial structure and disrupts energy metabolism in cultured neonatal rat cardiomyocytes

“…Some reports have proved the role of NPY in cardiomyopathies is beneficial [25], others have shown it to have detrimental effects [38]. The inconsistent results indicate that the role of NPY in different types of cardiomyopathies remains elusive.…”