Neuropeptide Y, galanin, and leptin release in obese women and in women with anorexia nervosa

Baranowska, B; Wasilewska-Dziubińska, Elżbieta; Radzikowska, M.; Pl̶lonowski, A.; Roguski, Krzysztof

doi:10.1016/s0026-0495(97)90136-0

Cited by 89 publications

(60 citation statements)

References 44 publications

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“…Congenital leptin deficiency in humans is associated with severe early-onset obesity. Somewhat paradoxically, however, plasma leptin levels are increased in obese women and decreased in women with anorexia nervosa (38).…”

Section: Discussionmentioning

confidence: 99%

Effect of Crude Saponin of Korean Red Ginseng on High-Fat Diet-Induced Obesity in the Rat

et al. 2005

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Abstract. The anti-obesity effects of crude saponin (CS) of Korean red ginseng (KRG) were investigated in the rat fed a high-fat (HF) diet. Male Sprague-Dawley (SD) rats became obese by feeding the HF diet over 5 weeks, while the control rats were fed a normal diet, and then both groups were treated with CS (200 mg / kg, i.p.) for 3 weeks. The body weight, food consumption, adipose tissues, and expression of appetite peptides such as leptin and neuropeptide Y (NPY) were investigated in rats fed normal and HF diet after treatment of CS. Administration of CS reduced body weight, food intake, and fat content in HF diet rats in a manner similar to those of the normal diet fed rats. The hypothalamic NPY expression and serum leptin level were reduced in HF diet rats after CS treatment. Our results suggest that CS may be useful in the treatment of obesity and related disorders as anti-obesity agents.

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Section: Discussionmentioning

confidence: 99%

Effect of Crude Saponin of Korean Red Ginseng on High-Fat Diet-Induced Obesity in the Rat

et al. 2005

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“…In another study, elevated serum levels of galanin were associated with a gain in body mass index in epileptic children treated with valproate (Cansu et al, 2011). Similarly, plasma galanin levels were increased in female patients with obesity and obese women with type 2 diabetes (Baranowska et al, 1997), although a separate study reported comparable plasma galanin concentrations in obese and normal weight women (Invitti et al, 1995). Hormonal status also appears to have an impact on galanin levels in obese women (Baranowska et al, 2000;Milewicz et al, 2000a).…”

Section: A Glucose Metabolism and Diabetesmentioning

confidence: 98%

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

et al. 2014

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“…For instance, people with anorexia nervosa who are underweight and malnourished have been found to have significantly increased concentrations of NPY in the cerebrospinal fluid compared to normal weight controls, and this change is significantly correlated with the decrease in serum and cerebrospinal fluid leptin concentrations (Kaye et al, 1990, Martinez et al, 1993, Hebebrand et al, 1995, Grinspoon et al, 1996, Baranowska et al, 1997, Ferron et al, 1997and Mantzoros et al, 1997. Moreover, the elevated cerebrospinal fluid NPY levels in people with anorexia nervosa are normalized when their eating behavior and body weight are restored to normal, suggesting that increases in central NPY levels may be a biological adaptation to energy deficit in humans (Kaye et al, 1990 andGendall et al, 1999) as well as in rodents.…”

Section: Insights From Humansmentioning

confidence: 99%

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit

Sainsbury

Zhang

2010

Molecular and Cellular Endocrinology

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Acute or long-term energy deficit in lean or obese rodents or humans stimulates food intake or appetite and reduces metabolic rate or energy expenditure. These changes contribute to weight regain in post-obese animals and humans. Some studies show that the reduction in metabolic rate with energy deficit in overweight people is transient. Energy restriction has been shown in some but not all studies to reduce physical activity, and this may represent an additional energy-conserving adaptation. Energy restriction up-regulates expression of the orexigenic neuropeptide Y, agouti related peptide and opioids and down-regulates that of the anorexigenic alpha-melanocyte stimulating hormone or its precursor pro-opioomelanocortin and the co-expressed cocaine and amphetamine-regulated transcript in the arcuate nucleus of the hypothalamus. Recapitulating these hypothalamic changes in sated animals mimics the effects of energy deficit, namely increased food intake, reduced physical activity and reduced metabolic rate, suggesting that these energy-conserving adaptations are at least partially mediated by the hypothalamus.

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Neuropeptide Y, galanin, and leptin release in obese women and in women with anorexia nervosa

Cited by 89 publications

References 44 publications

Effect of Crude Saponin of Korean Red Ginseng on High-Fat Diet-Induced Obesity in the Rat

Effect of Crude Saponin of Korean Red Ginseng on High-Fat Diet-Induced Obesity in the Rat

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit

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