Neuropeptide Regulation of Mucosal Immunity

Stead, Ron H.; Bienenstock, John; Stanisz, Andrzej

doi:10.1111/j.1600-065x.1987.tb00538.x

Cited by 164 publications

(46 citation statements)

References 87 publications

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“…We have also shown extensive mast cell/nerve structural membranemembrane associations in normal and inflamed rat intestines (9,10). Mast cell/nerve interactions may be important in various forms of neurogenic inflammation, in vivo and in the homeostatic regulation of various internal physiologic parameters (19)(20)(21)(22). We now hypothesize that NGF plays an accessory role in the regulation of basophil/mast cell growth and differentiation in allergic and nonallergic inflammatory processes.…”

mentioning

confidence: 98%

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

Matsuda

Coughlin

Bienenstock

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

218

125

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mentioning

confidence: 98%

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

Matsuda

Coughlin

Bienenstock

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

218

125

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“…Many lymphoid organs receive projections from adrenergic and peptidergic neurons [4,5]. The presence of vasoactive intestinal polypeptide (VIP)-, somatostatin-and substance P (SP)-immunoreactive (IR) nerve fibers in the Peyer's patches and the close vicinity to the immunocells [6,7] provides evidence of a structural foundation for communication between the immune and nervous systems in the gastrointestinal tract which might influence immune functions in this organ. In our previous study, the close relation between nerve fibers and lymphoid cells suggested that neuroimmune interaction exists in human colon, too [8,9].…”

Section: Introductionmentioning

confidence: 99%

Neuroimmune Interactions in Experimental Colitis

Fehér¹,

Altdorfer²,

Bagaméri³

et al. 2001

Neuroimmunomodulation

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With its abundance of neurons and immunocytes, the gut is a potentially important site for the study of the interaction between the nervous and immune systems. In this electron microscopic study we have investigated the distribution of substance P (SP)- and vasoactive intestinal polypeptide (VIP)-immunoreactive (IR) nerve terminals and the immunocytes during experimental colitis in the rat. A mild colitis was induced by a luminal enema containing trinitrobenzene sulfonic acid. The most severe inflammation was detected after 2 days and the density and the distribution of the SP- and VIP-IR nerve terminals as well as the immunocompetent cells were studied at that time. Many SP- and VIP-IR nerve terminals were observed in a very close situation to the inflammatory cells. The number of VIP-IR nerve terminals slightly increased in the inflamed area. The gap between the axolemma of the nerve terminals and immunocytes was 20–200 nm. Some lymphocytes and plasma cells were also IR for SP in the inflamed area, whereas no IR immunocytes were observed in the control and in noninflamed area from the same animal. The very close apposition of the SP- and VIP-IR nerve terminals to the inflammatory cells as well as the presence of SP-IR immunocytes in inflamed area support the suggestion that bidirectional neuroimmunomodulation exists in the colon.

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“…In particular, it is evident that the gut mucosal immune system is normally in an activated state. The notion that the gut immune cells are under neural influence is mostly supported by morphological studies that have revealed that neuropeptide-containing nerve endings are in close proximity to gut mucosal immune cells [2, 4]. Neuropeptides such as CGRP and substance P are known to have immune regulatory effects.…”

Section: Discussionmentioning

confidence: 86%

“…The gut contains several neuropeptides that are known to have immune regulatory actions in other tissues, and there is a lot of evidence that peptide-containing neurones may play a role in regulating gut immunity [2, 3, 4, 5]. For example, Peyer’s plaques, which are the primary lymphoid tissue of the gut mucosa, and the lamina propria, which contains many immune cells and is the effector site of the gut immune system, are supplied by nerves that contain neuropeptides that are known to exert potent effects on immune cells [6].…”

Section: Introductionmentioning

confidence: 99%

Calcitonin Receptor-Like Receptor Is Expressed on Gastrointestinal Immune Cells

et al. 2002

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Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact. We aimed to determine whether gut immune cells are targets for calcitonin gene-related peptide (CGRP), which has potent immune regulatory properties. Methods: Using density gradient centrifugation, rat lamina propria mononuclear cells (LP-MNCs) and intra-epithelial lymphocytes (IELs) were isolated. RT-PCR was employed for the detection of mRNA of rat calcitonin receptor-like receptor (CRLR), which is considered to represent the pharmacologically defined CGRP receptor-1 subtype, as well as mRNA of the receptor activity-modifying proteins, which are essential for CRLR function and determine ligand specificity. A radioreceptor assay was employed for the detection of specific CGRP binding sites. Results: RT-PCR and DNA sequencing showed that LP-MNCs and IELs express CRLR. Incubation of isolated LP-MNCs with radiolabelled αCGRP revealed the existence of specific binding sites for CGRP. Conclusion: These novel data indicate that mucosal immune cells of the rat gut are a target for CGRP and provide significant evidence that CGRP functions as an immune regulator in the gut mucosa.

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Neuropeptide Regulation of Mucosal Immunity

Cited by 164 publications

References 87 publications

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

Neuroimmune Interactions in Experimental Colitis

Calcitonin Receptor-Like Receptor Is Expressed on Gastrointestinal Immune Cells

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