Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide

Abstract

Neuromedin B (NMB) is a member of the neuromedin family of neuropeptides with a high level of region-specific expression in the brain. Several GWAS studies on non-obese and obese patients suggested that polymorphisms in NMB predispose to obesity by affecting appetite control and feeding preference. Furthermore, several studies proposed that NMB can act as an insulin releasing peptide. Since the functional study has never been done, the in vivo role of NMB as modulator of weight gain or glucose metabolism remains unclear. Here, we generated Nmb conditional mice and nervous system deficient NmB mice. We then performed olfactory and food preference analysis, as well as metabolic analysis under standard and high fat diet. Additionally, in direct islet studies we evaluated the role of NMB on basal and glucose-stimulated insulin secretion in mouse and humans.

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications

“…Neuromedin B and its receptor are highly expressed in AT. Cikes et al suggested that neuromedin B does not change body weight and glucose homeostasis on a standard diet nor acts as an insulin‑releasing peptide [ 164 ]. Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells.…”