Neuropeptide families: evolutionary perspectives

Hoyle, Charles H.V.

doi:10.1016/s0167-0115(97)01073-2

Cited by 159 publications

(101 citation statements)

References 262 publications

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“…The comparative endocrinology of the neurohypophysial hormones has been studied intensively, and a variety of related peptides has been revealed in non-mammalian vertebrates [1,15,29,30].…”

Section: Introductionmentioning

confidence: 99%

Molecular evolution of the neurohypophysial hormone precursors in mammals: Comparative genomics reveals novel mammalian oxytocin and vasopressin analogues

Wallis

2012

General and Comparative Endocrinology

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Among vertebrates the neurohypophysial hormones show considerable variation. However, in eutherian mammals they have been considered rather conserved, with arginine vasopressin (AVP) and oxytocin (OT) in all species except pig and some relatives, where lysine vasopressin replaces AVP. The availability of genomic data for a wide range of mammals makes it possible to assess whether these peptides and their precursors may be more variable in Eutheria than previously suspected. A survey of these data confirms that AVP and OT occur in most eutherians, but with exceptions. In a New-World monkey (marmoset, Callithrix jacchus) and in tree shrew (Tupaia

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“…The comparative endocrinology of the neurohypophysial hormones has been studied intensively, and a variety of related peptides has been revealed in non-mammalian vertebrates [1,15,29,30].…”

Section: Introductionmentioning

confidence: 99%

Molecular evolution of the neurohypophysial hormone precursors in mammals: Comparative genomics reveals novel mammalian oxytocin and vasopressin analogues

Wallis

2012

General and Comparative Endocrinology

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“…Pituitary Adenylate Cyclase-Activating Polypeptide 27 Is a Functional Ligand for Formyl Peptide Receptor-Like 1 1 T he two pituitary adenylate cyclase-activating polypeptides (PACAPs), 3 PACAP27 and PACAP38, are neuropeptides that belong to the secretin/glucagon/vasoactive intestinal peptide (VIP) family (1). PACAPs are multifunctional peptide hormones that influence diverse biological functions, e.g., the cell cycle, smooth muscle and cardiac muscle relaxation, bone metabolism, and endocrine/paracrine function (2).…”

mentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide 27 Is a Functional Ligand for Formyl Peptide Receptor-Like 1

Kim

Lee

Kim

et al. 2006

The Journal of Immunology

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Although the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in the regulation of several immune responses, its target receptors and signaling mechanisms have yet to be fully elucidated in immune cells. In this study, we found that PACAP27, but not PACAP38, specifically stimulated intracellular calcium mobilization and ERK phosphorylation in human neutrophils. Moreover, formyl peptide receptor-like 1 (FPRL1) was identified as a PACAP27 receptor, and PACAP27 was found to selectively stimulate intracellular calcium increase in FPRL1-transfected rat basophile leukocytes-2H3 cell lines. In addition, PACAP27-induced calcium increase and ERK phosphorylation were specifically inhibited by an FPRL1 antagonist, Trp-Arg-Trp-Trp-Trp-Trp (WRW4), thus supporting the notion that PACAP27 acts on FPRL1. In terms of the functional role of PACAP27, we found that the peptide stimulated CD11b surface up-regulation and neutrophil chemotactic migration, and that these responses were completely inhibited by WRW4. The interaction between PACAP27 and FPRL1 was analyzed further using truncated PACAPs and chimeric PACAPs using vasoactive intestinal peptide, and the C-terminal region of PACAP27 was found to perform a vital function in the activation of FPRL1. Taken together, our study suggests that PACAP27 activates phagocytes via FPRL1 activation, and that this results in proinflammatory behavior, involving chemotaxis and the up-regulation of CD11b.

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“…The sub-mammalian vertebrate VP homolog, vasotocin, also contains Arg at position 8, while the sub-mammalian vertebrate OT homologs, mesotocin and isotocin, harbor Ile at this position. Notably, one VP family peptide and one OT family peptide have been identified in most jawed vertebrates (Hoyle, 1998;Gimpl and Fahrenholz, 2001), although only one type of the OT/VP superfamily peptide has ever been found in cyclostomes and most invertebrates (Hoyle, 1998;Kawada et al, 2009b). Combined with the phylogenic position of cyclostomes as the stem species of vertebrates, the presence of vasotocin as the single member of the OT/VP superfamily in cyclostomes suggests that the OT family and VP family occurred via a gene duplication of the common ancestral gene during evolution from jawless fish to jawed fish.…”

Section: Vasopressin/oxytocin In C Intestinalismentioning

confidence: 99%

“…Combined with the phylogenic position of cyclostomes as the stem species of vertebrates, the presence of vasotocin as the single member of the OT/VP superfamily in cyclostomes suggests that the OT family and VP family occurred via a gene duplication of the common ancestral gene during evolution from jawless fish to jawed fish. OT/VP superfamily peptides have also been identified in invertebrates: molluscs, annelids, insects, sea urchins, amphioxus, and ascidians (Hoyle, 1998;Kawada et al, 2009b). Protostome and non-ascidian deuterostome invertebrate OT/VP superfamily peptides are all composed of nine amino acids, and share the OT/VP consensus amino acids (Table 5).…”

Section: Vasopressin/oxytocin In C Intestinalismentioning

confidence: 99%