Neuropeptide diuretic hormone 31 mediates memory and sleep via distinct neural pathways in Drosophila

Lyu, Sizhe; Terao, Noritaka; Nakashima, Hirofumi; Itoh, Motoyuki; Tonoki, Ayako

doi:10.1016/j.neures.2023.02.003

Cited by 6 publications

(2 citation statements)

References 64 publications

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“…In addition, we observed the differential expression of several genes involved in neuroendocrine signaling; among those being downregulated, there was the calcium-activated chloride channel regulator, crucial for the depolarization of neurons [71], and glutamic acid-rich proteins and glutamate receptor subunit 1 (NMDA), the main excitatory neurotransmitter of the central nervous system and their specific receptors [72]. Regarding upregulated genes, we found neuropeptide 31, which regulates many physiological activities in flies [73], neurotrophin 1, whose upregulation was previously observed in mice after the exposure to toluene [74], SRY-Box Transcription Factor 1 (SOX1), crucial for nervous system development in arthropods [75], and phosrestin 2, which is involved in photoreceptor function [76].…”

Section: Discussionmentioning

confidence: 95%

An In Vivo Whole-Transcriptomic Approach to Assess Developmental and Reproductive Impairments Caused by Flumequine in Daphnia magna

Pietropoli

Pauletto

Tolosi

et al. 2023

IJMS

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Among veterinary antibiotics, flumequine (FLU) is still widely used in aquaculture due to its efficacy and cost-effectiveness. Although it was synthesized more than 50 years ago, a complete toxicological framework of possible side effects on non-target species is still far from being achieved. The aim of this research was to investigate the FLU molecular mechanisms in Daphnia magna, a planktonic crustacean recognized as a model species for ecotoxicological studies. Two different FLU concentrations (2.0 mg L−1 and 0.2 mg L−1) were assayed in general accordance with OECD Guideline 211, with some proper adaptations. Exposure to FLU (2.0 mg L−1) caused alteration of phenotypic traits, with a significant reduction in survival rate, body growth, and reproduction. The lower concentration (0.2 mg L−1) did not affect phenotypic traits but modulated gene expression, an effect which was even more evident under the higher exposure level. Indeed, in daphnids exposed to 2.0 mg L−1 FLU, several genes related with growth, development, structural components, and antioxidant response were significantly modulated. To the best of our knowledge, this is the first work showing the impact of FLU on the transcriptome of D. magna.

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Section: Discussionmentioning

confidence: 95%

An In Vivo Whole-Transcriptomic Approach to Assess Developmental and Reproductive Impairments Caused by Flumequine in Daphnia magna

Pietropoli

Pauletto

Tolosi

et al. 2023

IJMS

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show abstract

“…This aligns with previous findings that MB ablation via hydroxyurea feeding did not alter the locomotor activity of rover and sitter larval morphs 33 . Our findings reveal that molecular markers for the MB (Fas2-and Mef2-positive) 34,35 , EB (Hk-and AstA-R1-positive) 36,37 , FB (Dh31-and ss-positive) 38,39 , and PI (Ilp2-positive but Ilp7-negative) 40 specifically overlap with foraging gene expression in certain neuronal populations (Fig. 2E-H).…”

Section: Memory Circuitry For Lmd Behavior Is Not Linked To the Funct...mentioning

confidence: 59%

Insights into theforagingGene’s Influence on Mating Investments of MaleDrosophila

Li,

Huang,

Kim

2024

Preprint

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Theforaginggene is a key genetic factor that modulates social behavior in insects, primarily by governing the trade-off between individual foraging and group-related activities. It has been associated with various behaviors associated with food search and resource exploitation, thereby playing a crucial role in determining the efficiency of foraging and the overall success of the collective. In this study, we investigate the critical role of theforaginggene in mediating complex interval timing behaviors, particularly mating duration, in the fruit flyDrosophila melanogaster. By examining two distinct variant phenotypes, rover and sitter, we observe specific deficiencies in longer (LMD) and shorter mating duration (SMD) behaviors, respectively, suggesting the gene’s crucial influence on these interval timing mechanisms. Utilizing single-cell RNA sequencing and knockdown experiments, we identify the gene’s significant expression in key neurons involved in learning and memory. However, its impact on mating duration is not observed in these brain regions. Instead, our data reveal the gene’s crucial role in specific neurons expressing Pdfr, a critical regulator of circadian rhythms. Furthermore, the study uncovers sexually dimorphic expression patterns in the brain and highlights the necessity of the gene’s dosage in specific cell populations within the ellipsoid body for normal mating duration. These findings underscore theforaginggene’s pivotal role in mediating complex interval timing behaviors inDrosophila, providing valuable insights into the intricate interplay between genetics, environment, and behavior. This research contributes to a deeper understanding of the genetic and neural mechanisms underlying complex interval timing behaviors, with broader implications for unraveling the function offoraginggene.

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NeuroPred-ResSE: Predicting neuropeptides by integrating residual block and squeeze-excitation attention mechanism

Liang,

Cao,

Zhang

2024

Analytical Biochemistry

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Neuropeptide diuretic hormone 31 mediates memory and sleep via distinct neural pathways in Drosophila

Cited by 6 publications

References 64 publications

An In Vivo Whole-Transcriptomic Approach to Assess Developmental and Reproductive Impairments Caused by Flumequine in Daphnia magna

An In Vivo Whole-Transcriptomic Approach to Assess Developmental and Reproductive Impairments Caused by Flumequine in Daphnia magna

Insights into theforagingGene’s Influence on Mating Investments of MaleDrosophila

NeuroPred-ResSE: Predicting neuropeptides by integrating residual block and squeeze-excitation attention mechanism

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