Neuropeptide B Induces Slow Wave Sleep in Mice

Hirashima, Noriko; Tsunematsu, Tomomi; Ichiki, Kanako; Tanaka, Hirokazu; Kilduff, Thomas S.; Yamanaka, Akihiro

doi:10.1093/sleep/34.1.31

Cited by 15 publications

(9 citation statements)

References 36 publications

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“…Surprisingly, both NPB and NPW were not found in the suprachiasmatic nucleus and nearby nuclei ( Tanaka et al, 2003 ; Jackson et al, 2006 ). Additionally, NPBWR1 gene knockout mice did not exert any abnormality in their basal pattern of sleep/wakefulness ( Uchio et al, 2009 ; Hirashima et al, 2011 ). Hirashima et al (2011) showed that administration of NPB in the dark period induced slow wave sleep and concluded that NPB with NPBWR1 may modulate the occurrence of sleep–wakefulness cycle.…”

Section: Physiological Effectsmentioning

confidence: 99%

Distribution and Function of Neuropeptides W/B Signaling System

Dvoráková

2018

Front. Physiol.

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Neuropeptide W (NPW) and neuropeptide B (NPB) are two structurally and functionally related regulatory peptides, which are highly expressed in several brain regions and, additionally, in some peripheral tissues. Nevertheless, their distributions in the tissues are not similar. They act on target tissues via two subtypes of G protein-coupled receptors which are designated as NPBWR1 (GPR7) and NPBWR2 (GPR8), respectively, and possess different binding affinities. NPB activates NPBWR1, whereas NPW stimulates both the receptors with similar potency. Both of these peptides takes a part in the central regulation of neuroendocrine axes, feeding behavior, energy homeostasis, cardiovascular functions, circadian rhythm, pain sensation, modulation of inflammatory pain, and emotions. Over the past few years, studies have shown that NPB is also involved in sleep regulation. On the contrary, NPW participates in regulation of vascular myogenic tone, inhibits gastric tension sensitive vagal afferents and insulin secretion. Also, expression of NPW in the stomach is regulated by feeding. Abovementioned findings clearly demonstrate the functional diversity among NPW versus NPB signaling systems. In this review, signal transduction pathways of NPW/NPB are critically evaluated and observed together with mapping of expression of their signaling systems.

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Section: Physiological Effectsmentioning

confidence: 99%

Distribution and Function of Neuropeptides W/B Signaling System

Dvoráková

2018

Front. Physiol.

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“…injection of NPB in mice reduced locomotor activity during the dark period, but not during the light phase. The activity of mice was measured using an infrared activity monitor [ 38 ]. In experiments using Npb−/− mice, no significant differences in activity levels were found compared to littermate controls [ 33 ].…”

Section: The Role Of Npb In Brainmentioning

confidence: 99%

“…injection of NPB in mice during the dark period decreased time in the waking state and increased time in slow-wave sleep, whereas no change in paradoxical sleep time was observed. Moreover, NPBWR1+/− and NPBWR1−/− mice did not present any abnormalities compared with wild-type mice, indicating a modulatory role of NPB and NPBWR1 in the sleep/wakefulness pattern [ 38 ].…”

Section: The Role Of Npb In Brainmentioning

confidence: 99%

The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis

Wojciechowicz

Billert

Jasaszwili

et al. 2021

IJMS

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Neuropeptide B (NPB) is a peptide hormone that was initially described in 2002. In humans, the biological effects of NPB depend on the activation of two G protein-coupled receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), and, in rodents, NPBWR1. NPB and its receptors are expressed in the central nervous system (CNS) and in peripheral tissues. NPB is also present in the circulation. In the CNS, NPB modulates appetite, reproduction, pain, anxiety, and emotions. In the peripheral tissues, NPB controls secretion of adrenal hormones, pancreatic beta cells, and various functions of adipose tissue. Experimental downregulation of either NPB or NPBWR1 leads to adiposity. Here, we review the literature with regard to NPB-dependent control of metabolism and energy homeostasis.

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“…Neuropeptide B is reported to induce slow wave sleep in mice when injected intracerebroventricularly (Hirashima et al, 2011). However, since NPBWR1 − /− mice did not show any sleep abnormality, the biological relevance of this finding remains unclear.…”

Section: Biological Activities Of Npb and Npwmentioning

confidence: 99%

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

Sakurai¹

2013

Front. Endocrinol.

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Neuropeptide B/W receptor-1 (NPBWR1) and NPBWR2 had been known as orphan receptors GPR7 and 8, respectively. Endogenous peptide ligands of these receptors, neuropeptide B (NPB) and neuropeptide W (NPW), were identified in 2002 and 2003 (Fujii et al., 2002; Brezillon et al., 2003; Tanaka et al., 2003). These peptides have been implicated in regulation of feeding behavior, energy homeostasis, neuroendocrine function, and modulating inflammatory pain. In addition, strong and discrete expression of their receptors in the extended amygdala and bed nucleus of the stria terminalis suggests a potential role in regulating stress responses, emotion, anxiety, and fear. Recent studies of NPB/NPW using both pharmacological and phenotypic analyses of genetically engineered mice as well as a human study support this hypothesis.

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Neuropeptide B Induces Slow Wave Sleep in Mice

Abstract: These results suggest that NPB induced physiological SWS through GPR7 and that NPB and GPR7 may have a role in modulating the occurrence of sleep and wakefulness.

Cited by 15 publications

References 36 publications

Distribution and Function of Neuropeptides W/B Signaling System

Distribution and Function of Neuropeptides W/B Signaling System

The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

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