NeuroPep: a comprehensive resource of neuropeptides

Wang, Yan; Wang, Mingxia; Yin, Sanwen; Jang, Richard; Wang, Jian; Xue, Zhidong; Xu, Tao

doi:10.1093/database/bav038

Cited by 118 publications

(114 citation statements)

References 26 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…Then, the open reading frames of the resulting unigenes were predicted using the orffinder tool from NCBI (https://www.ncbi.nlm.nih.gov/orffinder/) and the predicted protein sequences were used in a blastp analysis to confirm their identity as neuropeptide. Finally, the S. exigua neuropeptides were classified in families using the databases NeuroPep (isyslab.info/NeuroPep; Wang et al ., ) and DINeR (https://neurostresspep.eu/diner/; Yeoh et al ., ).…”

Section: Methodsmentioning

confidence: 99%

Identification and expression analysis of the Spodoptera exigua neuropeptidome under different physiological conditions

Llopis-Giménez

Han

Kim

et al. 2018

Insect Molecular Biology

View full text Add to dashboard Cite

Neuropeptides are small signalling molecules acting as neurohormones, neurotransmitters and neuromodulators. Being part of the chemical communication system between cells within an organism, they are involved in the regulation of different aspects of animal physiology and behaviour such as feeding, reproduction, development and locomotion. Transcriptomic data from larval and adult tissues have been obtained and mined to generate a comprehensive neuropeptidome for the polyphagous insect pest Spodoptera exigua. Sixty-three neuropeptides have been identified and described based on their tissue specificity and their regulation in response to different abiotic perturbations. Expression analyses have identified those neuropeptides involved in ingestive and digestive behaviour of S. exigua larvae and revealed a general pattern of upregulation in the midgut during larval starvation. Our results represent a comprehensive neuropeptidome of a lepidopteran species that will be highly relevant to future studies and provide novel information of the insect's perception of its environment.

show abstract

Section: Methodsmentioning

confidence: 99%

Identification and expression analysis of the Spodoptera exigua neuropeptidome under different physiological conditions

Llopis-Giménez

Han

Kim

et al. 2018

Insect Molecular Biology

View full text Add to dashboard Cite

show abstract

“…The www.neuropeptides.nl are complemented by recent development of NeuroPep [18] which is a comprehensive resource of neuropeptides, which holds 5949 non-redundant neuropeptide entries from 493 vertebrate and invertebrate organisms. Each peptide entry of the database contains organisms, tissues, families, names, modifications, 3D structures (if known), and literature references.…”

Section: Bioinformatics For Neuropeptidomics By Neuropedia: Neuropeptmentioning

confidence: 99%

Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems

Hook

Bandeira

2015

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Neuropeptides regulate intercellular signaling among cells of the central brain and peripheral nervous systems, and the endocrine system. Diverse neuropeptides of distinct primary sequences of various lengths, often with post-translational modifications, coordinate and integrate regulation of physiological functions. Mass spectrometry-based analyses of the diverse neuropeptide structures in neuropeptidomics research is necessary to define the full complement of neuropeptide signaling molecules. Human neuropeptidomics has notable importance in defining normal and dysfunctional neuropeptide signaling in human health and disease. Neuropeptidomics has great potential for expansion in translational research opportunities for defining neuropeptide mechanisms of human diseases, providing novel neuropeptide drug targets for drug discovery, and monitoring neuropeptides as biomarkers of drug responses. In consideration of the high impact of human neuropeptidomics for health, an observed gap in this discipline is the few published articles in human neuropeptidomics compared to, for example, human proteomics and related mass spectrometry disciplines. Focus on human neuropeptidomics will advance new knowledge of the complex neuropeptide signaling networks participating in the fine control of neuroendocrine systems. This commentary review article discusses several human neuropeptidomics accomplishments that illustrate the rapidly expanding diversity of neuropeptides generated by protease processing of pro-neuropeptide precursors occurring within the secretory vesicle proteome. Of particular interest is the finding that human-specific cathepsin V participates in producing enkephalin and likely other neuropeptides, indicating unique proteolytic mechanisms for generating human neuropeptides. The field of human neuropeptidomics has great promise to solve new mechanisms in disease conditions, leading to new drug targets and therapeutic agents for human diseases.

show abstract

“…However, it does not curate arthropod neuropeptides. Another neuropeptide website, 'NeuroPep' (http://isyslab.info/NeuroPep/ home.jsp), contains 21 arthropod neuropeptide families, less than half those known (Wang et al, 2015). DINeR (http://www.neurostresspep.eu/diner/) is a web-based database application dedicated to insect neuropeptide information of multiple insect species detailing their peptide sequences, physiological functionality and images of their receptor-binding sites.…”

Section: Introductionmentioning

confidence: 99%

DINeR — A Database for Insect Neuropeptide Research

Pandit¹

2016

2016 International Congress of Entomology

View full text Add to dashboard Cite

a b s t r a c tNeuropeptides are responsible for regulating a variety of functions, including development, metabolism, water and ion homeostasis, and as neuromodulators in circuits of the central nervous system. Numerous neuropeptides have been identified and characterized. However, both discovery and functional characterization of neuropeptides across the massive Class Insecta has been sporadic. To leverage advances in post-genomic technologies for this rapidly growing field, insect neuroendocrinology requires a consolidated, comprehensive and standardised resource for managing neuropeptide information.The Database for Insect Neuropeptide Research (DINeR) is a web-based database-application used for search and retrieval of neuropeptide information of various insect species detailing their isoform sequences, physiological functionality and images of their receptor-binding sites, in an intuitive, accessible and user-friendly format. The curated data includes representatives of 50 well described neuropeptide families from over 400 different insect species. Approximately 4700 FASTA formatted, neuropeptide isoform amino acid sequences and over 200 records of physiological functionality have been recorded based on published literature. Also available are images of neuropeptide receptor locations. In addition, the data include comprehensive summaries for each neuropeptide family, including their function, location, known functionality, as well as cladograms, sequence alignments and logos covering most insect orders. Moreover, we have adopted a standardised nomenclature to address inconsistent classification of neuropeptides.As part of the H2020 nEUROSTRESSPEP project, the data will be actively maintained and curated, ensuring a comprehensive and standardised resource for the scientific community. DINeR is publicly available at the project website: http://www.neurostresspep.eu/diner/.

show abstract

NeuroPep: a comprehensive resource of neuropeptides

Cited by 118 publications

References 26 publications

Identification and expression analysis of the Spodoptera exigua neuropeptidome under different physiological conditions

Identification and expression analysis of the Spodoptera exigua neuropeptidome under different physiological conditions

Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems

DINeR — A Database for Insect Neuropeptide Research

Contact Info

Product

Resources

About