Neuropathy Caused by Drugs

Herskovitz, Steven; Schaumburg, Herbert H.

doi:10.1016/b978-0-7216-9491-7.50117-4

Cited by 13 publications

(12 citation statements)

References 319 publications

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“…Sural nerve biopsies in patients with polyneuropathies that were induced by medications that treat infectious diseases (e.g., dapsone, isoniazid, metronidazole, and nitrofurantoin) or chronic illnesses (e.g., amiodarone, disulfiram, nitrous oxide, and thalidomide) display variable degrees of distal axonopathies. These drugs are known to produce neuropathy by impairing axonal transport or other cellular functions . Several factors emphasize this increased vulnerability in porphyric neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation and electrophysiological findings of porphyric neuropathies: A follow‐up study

Jung

et al. 2015

Muscle and Nerve

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Section: Discussionmentioning

confidence: 99%

Clinical presentation and electrophysiological findings of porphyric neuropathies: A follow‐up study

Jung

et al. 2015

Muscle and Nerve

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“…Sural biopsies in patients with polyneuropathies that were induced by medications that are used for infectious diseases (e.g., metronidazole and nitrofurantoin) or chronic illnesses (e.g., amiodarone and thalidomide) display variable degrees of distal axonopathies. These drugs are known to produce neuropathy by impairing axonal transport or other cellular functions . Unlike most acquired axonopathies that show preferential damage to larger fibers, both myelinated and unmyelinated fibers were severely damaged in the biopsied nerve of Patient III‐10.…”

Section: Discussionmentioning

confidence: 99%

Porphyric neuropathies in an acute intermittent porphyria family

Kuo

Jung

et al. 2015

Neuropathology

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The objective of this study was to investigate two patients with porphyric neuropathy in a family with acute intermittent porphyria. Molecular analysis of the porphobilinogen deaminase (PBGD) gene was performed. We analyzed the clinical course of peripheral neuropathy and serial changes in nerve conduction studies (NCS) of the two patients. We also examined the pathological findings of sural nerve biopsy in one patient. Molecular analysis of the PBGD gene revealed a missense mutation (Arg26His) in exon 2 for two patients and their family members. Distal polyneuropathy was noted in the patients with chronic porphyric neuropathy. In the follow-up NCS, recovery was relatively poor in the lower limb in one patient with severe polyneuropathy, and NCS evidence of deterioration was found following frequent hormone-related porphyric attacks in another patient. The sural nerve biopsy showed marked loss of myelinated and unmyelinated fibers in one patient with chronic porphyric neuropathy. In contrast to radial and fibular motor nerves in acute porphyric neuropathy, the sural nerve is vulnerable to involvement in chronic porphyric neuropathy following repeated porphyric attack as seen in the NCS.

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“…These include arsenic [63], amphiphilic cationic drugs (amiodarone and perhexiline), vincristine, cisplatin, pyridoxin, disulfiram, gold salts, glue, alcohol, and organophosphates [15,50,71,154]. A severe sensory neuronopathy may occur as a complication to ingestion of amounts of pyridoxine (vitamin B6) that greatly exceeds the daily recommended dose of 2.5 mg [133].…”

Section: Acute Neuropathies Induced By Toxinsmentioning

confidence: 98%

Diagnosis of acute neuropathies

Crone

Krarup

2007

J Neurol

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Acute and subacute polyneuropathies present diagnostic challenges since many require prompt initiation of treatment in order to limit axonal degeneration and since an exact and detailed diagnosis is a prerequisite for making the correct choice of treatment. It is for instance of utmost importance to recognize whether the underlying pathological changes are due to demyelination or to axonal degeneration and electrodiagnostic tests can thus in most cases contribute considerably to the securing of an exact diagnosis. The specific and characteristic electrophysiological findings in the different types of acute and subacute neuropathies are discussed, and the various electrophysiological pitfalls and technical problems, which are met in these patients, are mentioned.

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Neuropathy Caused by Drugs

Cited by 13 publications

References 319 publications

Clinical presentation and electrophysiological findings of porphyric neuropathies: A follow‐up study

Clinical presentation and electrophysiological findings of porphyric neuropathies: A follow‐up study

Porphyric neuropathies in an acute intermittent porphyria family

Diagnosis of acute neuropathies

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