Neuropathy and levodopa in Parkinson's disease: Evidence from a multicenter study

Abstract

The objectives of this study were to evaluate the risk of neuropathy in patients with Parkinson's disease (PD) (P = 0.022; OR, 2.38; 95% CI,. In a comparison between patients with and without neuropathy (Student's ttest), the levodopa dose was higher (P < 0.0001), serum vitamin B12 levels were lower (P = 0.0102), and homocysteine levels were higher (P < 0.001) Parkinson's disease (PD) is a common neurodegenerative disorder that can cause significant disability and decreases quality of life. The cardinal physical signs of the disease are distal resting

Effects of levodopa/carbidopa intestinal gel versus oral levodopa/carbidopa on B vitamin levels and neuropathy

“…It was predominantly axonal in nature. This proportion was much vaster than previously reported prevalences, which range from 5% to ~40% (Ceravolo et al., 2013; Jugel et al., 2013; Merola et al., 2014, 2016; Rajabally & Martey, 2011; Shahrizaila et al., 2013; Toth, Brown, Furtado, Suchowersky, & Zochodne, 2008; Toth et al., 2010). The frequency in our LCIG group was 100% (6 of 6), in the oral group 73% (8 of 11).…”

“…Looking at our results, this is exactly the case—cobalamin and folate were low in both groups, but still within normal range, homocysteine was high above upper limit. This result is in line with previous findings (Ceravolo et al., 2013; Mancini et al., 2014; Merola et al., 2014; Rajabally & Martey, 2011; Santos‐Garcia, Macias, Llaneza, Grande, & Fuente‐Fernandez, 2011; Toth et al., 2010). All three values did not significantly differ between LCIG and orally treated patients.…”

“…Cobalamin deficiency as a potential cause of neuropathy in IPD has been investigated extensively, but with conflicting results: in levodopa‐treated IPD patients, cobalamin has been shown to be lower in those with neuropathy than in those without it (Ceravolo et al., 2013; Mancini et al., 2014); some researchers have found an association between cobalamin levels and levodopa doses (Rajabally & Martey, 2013; Toth et al., 2010), but this finding could not be confirmed by others (Mancini et al., 2014). Also folate deficiency (Rajabally & Martey, 2013) and levodopa itself, especially LCIG and its ingredients or its way of resorption (Jugel et al., 2013), have been suspected to be involved in the development of neuropathy in IPD.…”

Polyneuropathie im Alter

“…Die Höhe der L-Dopa-Dosierungkorreliert mit dem Schweregrad der PNP [29]. Erhöhte Homocysteinund Methylmalonsäurespiegel sind Zeichen eines Vitamin-B12-Mangels.…”

Peripheral nervous system involvement in Parkinson's disease: Evidence and controversies

“…Studies investigating the frequency of PN in PD patients on LD therapy, detected a significant increase compared to age-matched healthy subjects, although the reported data range varied from 4.8% [25] to 55% [26] (Table 2). This wide discrepancy is probably due to intrinsic differences of the study population in terms of age, disease duration and therapeutic regimen, as well as of the methodology used to detect PN: i) clinical signs only versus neurophysiological data, ii) diagnostic criteria used for diagnosis.…”