Neuropathy After Intake of Thalidomide (Distaval)

Fullerton, Pamela M.; Kremer, Michael

doi:10.1136/bmj.2.5256.855

Cited by 123 publications

(36 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These demonstrated a dramatic improvement in the function of nerves affected by ENL neuritis as a result of treatment with thalidomide. This is particularly important as , in the past, small numbers of non-leprous patients were reported to have developed neuropathy (predominantly a sensory peripheral neuritis) after intake of thalidomide (Fullerton and Kremer, 1961). No neurotoxic effects of thalidomide have been reported to date in lepromatous patients, and it is considered that the drug's undoubted beneficial action in established ENL neuritis completely outweighs any slight theoretical risk of neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

An Internally-controlled Double Blind Trial of Thalidomide in Severe Erythema Nodosum Leprosum

Waters¹

1971

Leprosy Review

View full text Add to dashboard Cite

A double-blind, internally-controlled, clinical trial of thalidpmide in severe, chronic, histologically-proven erythema nodosum leprosum (ENL) is reported. A total of 10 adult male patients were admitted to the trial, all of whom were receiving continuous treatment with steroids and whose minimum daily requirement just to suppress the reaction was in no case less than 15 mg of prednisolone or 18 international units of corticotrophin. The trial wa s divided into 4 equal parts (of either 4 or 6 weeks' duration) consisting of an initial control period, first and second trial periods, and a final control period. Throughout the trial all patients received DDS, 100 mg twice weekly ; thalidomide, 300 mg daily, wa s given during one trial period and identical placebo tablets during the other. As judged by the red uction in their steroid requirements, 9 of the 10 patients showed a very significant improvement while they were receiving thalidomide, although 7 subsequently relapsed after stopping the drug. There was no dose-for-dose relationship between thalidomide and prednisolone. Two patients developed a mild allergic dermatitis.

show abstract

Section: Discussionmentioning

confidence: 99%

An Internally-controlled Double Blind Trial of Thalidomide in Severe Erythema Nodosum Leprosum

Waters¹

1971

Leprosy Review

View full text Add to dashboard Cite

show abstract

“…A well-documented side-effect of thalidomide is peripheral neuropathy (Fullerton and Kremer, 1961) and dose reductions due to this were required in 5 patients. The most common side effects that we observed were constipation, which responded well to laxatives, neuropathy and lethargy.…”

Section: Discussionmentioning

confidence: 99%

“…Any woman of child-bearing potential had to have a negative pregnancy test prior to receiving thalidomide and use adequate contraception during the study. Patients with preexisting peripheral neuropathy of WHO grade 2 or greater as assessed by sensory nerve action potential (SNAP) testing were not eligible (Fullerton and Kremer, 1961).…”

Section: Patient Identification and Eligibilitymentioning

confidence: 99%

The treatment of advanced renal cell cancer with high-dose oral thalidomide

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Because prednisone may reduce anticoagulant activity, treatment with this drug has been advocated in LAC-positive pregnant patients in order to decrease or abolish assumed harmful effects of LAC on the placenta (4). Recently, the presence of ACL antibodies was claimed to be a more reliable predictor for fetal distress or death than LAC (5). However, data on the effect of prednisone on titers of ACL antibodies are lacking.…”

Section: To the Editormentioning

confidence: 99%