NEUROPATHOLOGY OF SUBACUTE MYELO-OPTICO-NEUROPATHY, ^|^ldquo;SMON^|^rdquo;

Abstract

Neuropathology of 14 autopsy cases of acute to chronic •gSMON•h •g SMON•h onset was discussed. (Same case as in Fig. 2 B) A. Typical •ggreen tongue•h consisting of conspicuous hyperkeratosis and its stalk-like formation and hematoxophilic, thick coating masses attached to the former, •~ 89. B. Slightly more advanced stage of the •ggreen tongue•h than A. Deeply-stained, pronounced hyperkeratosis. •~ 86. C. Magnified area in A .

Some observations on SMON from Bombay.

“…The widely held view, shared by Japanese authors (Kono, 1971;Tsubaki et al, 1971;Shiraki, 1973), that SMON is rare outside Japan appears to be confirmed by this study. Whereas some 10,000 cases of SMON were reported from Japan over a 15 year period, we have only been able to find nine cases in Bombay, in a little over nine years.…”

“…The disproportionately high prevalence of this disease in Japan has been commented on by the Japanese themselves (Kono, 1971;Tsubaki et al, 1971;Shiraki, 1973). Tsubaki et al, (1971) were the first to point out that most of their patients had taken clioquinol before the onset of this disease.…”

Neuronal and Muscular Inclusions in Rats with Hindlimb Dysfunction after Treating with Difluorobenzhydrylpiperadine

“…Especially the lumbar ganglia innervating the limbs and feet possess the 2 longest axons toward the periphery and center and are sensitive to various chemicals. Clioquinol is known to affect mainly at posterior funicles of the spinal cord, a pathway of the central fibers from the dorsal root ganglia (33). Organophosphate (21) was described to produce lesions in the distal portion of both central and peripheral fibers, whereas doxorubicin (9) affected only the cell body of the dorsal root ganglia.…”

Arousal response induced by postural changes in patients with subacute myelo-optico-neuropathy, "SMON".

“…It is reasonable to expect that pathophysiological processes of this phenomenon are taking place not in the peripheral but in the central nervous system. Neuropathological studies of SMON have suggested a possibility that there is a regenerating process of axon collaterals in the Goll's tract during longstanding clinical courses (Shiraki 1975(Shiraki , 1979. Early researches of SMON reported that the majority of SMON patients showed severe and moderate histological changes in the Goll's tract and most of them had severe sensory disturbance (Egashira 1975).…”